Neutrophil lymphocyte ratio significantly improves the Framingham risk score in prediction of coronary heart disease mortality: Insights from the National Health and Nutrition Examination Survey-III

Shah, Neeraj; Parikh, Valay; Patel, Nileshkumar; Patel, Nilay; Badheka, Apurva; Deshmukh, Abhishek; Rathod, Ankit; Lafferty, James

doi:10.1016/j.ijcard.2013.12.019

Cited by 146 publications

(144 citation statements)

References 87 publications

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“…3,4 Neutrophil to lymphocyte ratio (NLR) is a predictor of all-cause 5 and cardiovascular mortality 6 among patients with coronary artery disease, and NLR was also found to be a long-term predictor of death from ischemic heart disease in a cohort without coronary heart disease at baseline. 7 In contrast to CRP, 8 NLR was associated with risk of first-ever stroke in patients with atrial fibrillation, and adding NLR to the CHA2DS2-VASc score improved the predictability of the score. 9 The latter finding may suggest that NLR is superior to CRP to predict thromboembolic complications in low-grade inflammation.…”

mentioning

confidence: 98%

Neutrophil to lymphocyte ratio and future risk of venous thromboembolism and mortality: the Tromso Study

et al. 2016

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mentioning

confidence: 98%

Neutrophil to lymphocyte ratio and future risk of venous thromboembolism and mortality: the Tromso Study

et al. 2016

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“…Inflammation has a central role in the pathogenesis of atherosclerosis (13). NLR is being used as a new inflammatory marker in many diseases to identify higher risk patients (7)(8)(9)16,17). In a study, NLR was found to be associated with the severity of coronary artery disease and 30year survival (7).…”

Section: Discussionmentioning

confidence: 99%

“…NLR may be sensitive in detecting cardiovascular risk. NLR was found to be associated with increased adverse outcomes in oncologic (6) and cardiovascular diseases (7)(8)(9). In chronic kidney disease (CKD), NLR was related to renal functional deterioration (10) and endothelial dysfunction (11).…”

Section: Introductionmentioning

confidence: 99%

Does Neutrophil to Lymphocyte Ratio Tell Something About Atherosclerosis in Hemodialysis Patients?

Yayar¹,

Eser²,

Oğuz³

et al. 2017

Turk Neph Dial Transpl

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OBJECTIVE: Atherosclerotic cardiovascular disease (CVD) is an important cause of mortality and morbidity in end-stage renal disease (ESRD). Atherosclerotic changes in carotid arteries show the extent of systemic atherosclerosis. Carotid intima media thickness (CIMT) can be measured by ultrasonography. Inflammation is included in pathogenesis of atherosclerosis. Neutrophil to lymphocyte ratio (NLR) may show inflammation and the patients who has higher cardiovascular risk. The aim of this study was to detect the relationship between NLR, C-reactive protein and CIMT. MATERIAL and METHODS:75 hemodialysis patients (42 female, 33 male) were included in this study. Patients with active infection, known malignancy and a cardiovascular disease were excluded. CIMT was measured by B mode ultrasonography. Patients' laboratory parameters at the time of inclusion were noted and NLR was calculated. RESULTS:Mean age was 58.07±16.23 years and 44% of the patients were male. Mean dialysis vintage was 79.27±67.06 months. In correlation analysis, CIMT was positively correlated with age, CRP and NLR (respectively r=.380 p=.001; r=.255 p=.005; r=.283 p=.014). By regression analysis age (β=.527, p=0.00), CRP (β=.419, p=0.001) and NLR (β=.251, p=0.022) were found to be independent determinants of CIMT. CONCLUSION:NLR was found to be independently correlated with CIMT in haemodialysis patients and may be used in cardiovascular risk assessment in clinical practice. KEy wORDS:Neutrophil to lymphocyte ratio, Haemodialysis, Cardiovascular disease Öz AMAÇ: Son dönem böbrek yetmezliğinde (SDBY) kardiyovasküler hastalık mortalite ve morbiditenin en önemli nedenidir. Aterosklerozun göstergesi olan karotis intima medya kalınlığında (KİMK) artış SDBY de kardiyovasküler hastalığın bir belirtecidir. İnflamasyon aterosklerozun patogenezinde rol oynamaktadır. Beyaz küre sayısının kardiyovasküler olaylar için bağımsız bir belirteç olduğu bildirilmektedir. Nötofil-lenfosit oranı (NLO) kardiyovasküler olaylar açısından risk altında olan hastaları gösterebilir. SDBY nedeniyle hemodiyalize giren hastalarda ateroskleroz belirteci olan KİMK ile NLO ve CRP arasında ilişki olup olmadığını araştırmayı hedefledik. GEREÇ ve yÖNTEMLER:Bu kesitsel çalışmaya hastanemiz hemodiyaliz ünitesinde en az 6 aydır hemodiyalize giren, bilinen aktif enfeksiyonu, kardiyovasküler hastalığı, malignitesi olmayan 75 hasta (42 kadın, 33 erkek) dahil edildi. Hastaların KİMK'ları B mod ultrasonografi kullanılarak ölçüldü. Hastaların çalışmaya dahil edildikleri andaki laboratuvar parametreleri kaydedilerek nötrofil lenfosit oranları hesaplandı.BULGULAR: Ortalama yaş 58.07±16.23 yıl idi ve hastaların %44 ü erkek idi. Ortalama diyaliz süresi 79,27±67,06 ay idi. Yapılan korelasyon analizinde KİMK nın yaş, CRP ve NLO ile pozitif korele olduğu tespit edildi (sırasıyla r=,380 p=,001 ; r=,255 p=,005; r=,283 p=,014). Yapılan regresyon analizinde yaş (β=,527, p=0,00), CRP (β=,419, p=0,001) ve NLO (β=,251, p=0,022) nun KİMK nın bağımsız belirleyicileri olduğu tespit edildi. SONUÇ: SDBY n...

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“…NLR is being widely used to identify high-risk patients with various illnesses, including cancer [39] and CVD [39][40][41][42] . In our paper, we discussed NLR and clinical outcomes in patients with ESRD.…”

Section: Potential Role Of Nlr As An Inflammatory Biomarkermentioning

confidence: 99%

Neutrophil/lymphocyte ratio: A promising prognostic marker in patients with chronic kidney disease

Kato

Abe²,

Lindholm³

et al. 2015

Inflamm Cell Signal

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Chronic kidney disease (CKD), especially end-stage renal disease (ESRD), is associated with high morbidity and mortality due to cardiovascular disease (CVD) and infection, two common complications of ESRD that may be related, in part, to chronic inflammation and protein-energy wasting (PEW). Recently, in a Japanese prospective cohort study, we reported that there was significantly higher risk for CVD-related events in CKD patients with an increased neutrophil/lymphocyte ratio (NLR) at the start of their dialysis therapy. Because higher neutrophil count reflects inflammation and lower lymphocyte count may reflect malnutrition, NLR is hypothesized to be a more sensitive index than other existing inflammatory markers for detecting those at high risk for CVD-related events. This research highlight describes the potentials of NLR as a prognostic marker in patients with CKD. Although further studies are required to better understand its value as prognostic tool in clinical practice, current data suggest that NLR may be a useful and inexpensive marker for identifying CKD patients at high risk for CVD-related complications.

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Neutrophil lymphocyte ratio significantly improves the Framingham risk score in prediction of coronary heart disease mortality: Insights from the National Health and Nutrition Examination Survey-III

Cited by 146 publications

References 87 publications

Neutrophil to lymphocyte ratio and future risk of venous thromboembolism and mortality: the Tromso Study

Neutrophil to lymphocyte ratio and future risk of venous thromboembolism and mortality: the Tromso Study

Does Neutrophil to Lymphocyte Ratio Tell Something About Atherosclerosis in Hemodialysis Patients?

Neutrophil/lymphocyte ratio: A promising prognostic marker in patients with chronic kidney disease

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