Neutrophil/Lymphocyte Ratio, Serum Endocan, and Nesfatin-1 Levels in Patients with Psoriasis Vulgaris Undergoing Phototherapy Treatment

Abstract

BackgroundPsoriasis is an autoimmune, inflammatory, and chronic disease. Recent studies have evaluated serum endocan and nesfatin-1 levels in patients with inflammatory disorders. The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker currently used in many diseases. The aim of the present study was to evaluate NLR, serum endocan, and nesfatin-1 levels in psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy treatment and compared to healthy controls.Material/MethodsThis study was conducted on a total of 88 cases, 39 of which had psoriasis vulgaris and 49 were healthy volunteers. Thirty-nine psoriasis vulgaris patients underwent NB-UVB phototherapy treatment for 3 months. NLR, serum endocan, and nesfatin-1 levels were measured in all psoriasis patients before and after NB-UVB phototherapy and in the control group.ResultsCompared with the control group, neutrophil count and NLR were significantly higher (p<0.001) in psoriasis patients before NB-UVB phototherapy. Serum endocan levels were significantly correlated with disease activity before treatment. There was no significant difference in NLR, serum endocan, and nesfatin-1 levels in psoriasis patients before and after NB-UVB phototherapy (p>0.05).ConclusionsThe current study shows that NLR was higher in psoriasis vulgaris patients when compared with the control group, whereas serum endocan and nesfatin-1 levels were not significantly different. In addition, NB-UVB phototherapy did not affect NLR, serum endocan, or nesfatin-1 levels. Further larger-scale studies are required on this subject.

Increased endocan expression in lesional skin and decreased endocan expression in sera in atopic dermatitis

“…reported that serum endocan levels were increased in patients with psoriasis vulgaris and correlated with disease activity . On the other hand, there is another report describing that serum endocan levels in patients with psoriasis vulgaris are comparable with those in healthy controls . In addition, also in lichen planus, endocan levels are not increased in the sera .…”

Decreased Systemic Levels of Endocan-1 and CXCL16 in Psoriasis Are Restored following Narrowband UVB Treatment

“…Balta et al [23] identified elevated levels of endocan-1 in psoriasis, which also correlated positively to disease severity. However, this elevation was not replicated by Erek Toprak et al [24], who found no differences in endocan-1 levels between psoriasis patients and controls. This emphasizes that the role of endocan-1 in psoriasis is uncertain and not yet fully explored.…”

Novel inflammatory markers in patients with psoriasis

“…Erek et al evaluated NLR in 88 individuals including 39 patients with psoriasis and 49 healthy controls and reported that the NLR levels were significantly higher in the patients compared to the controls and the narrow-band ultraviolet B (NB-UVB) phototherapy treatment had no effect on NLR. In contrast, although we did not evaluate pre-and post-treatment values, our study had a larger patient population and also evaluated MPV and PLR in our patients (9). Cemil et al evaluated 42 patients with psoriasis and suggested that both NLR and PLR can be effectively used in patients receiving biologic treatment of psoriasis (4).…”