Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can risk stratify patients in transcatheter aortic-valve replacement (TAVR)

Condado, José F.; Junpaparp, Parichart; Binongo, José; Lasanajak, Yi; Witzke-Sanz, Christian F.; Devireddy, Chandan; Leshnower, Bradley G.; Mavromatis, Kreton; Stewart, James; Guyton, Robert A.; Wheeler, David; Forcillo, Jessica; Patel, Ateet; Block, Peter C.; Thourani, Vinod H.; Rangaswami, Janani; Babaliaros, Vasilis

doi:10.1016/j.ijcard.2016.08.260

Cited by 49 publications

(42 citation statements)

References 17 publications

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“…20 Another study in patients undergoing transcatheter aortic valve replacement showed that higher increase in NLR after valve implantation was associated with worse survival. 21 Of note, baseline NLR in the same study was not associated with survival. In HTX, patients routinely receive immunosuppressive therapy including high-dose steroids, starting within surgery and continued afterwards.…”

Section: Discussionmentioning

confidence: 87%

“…One study, however, showed that both pre‐operative and post‐operative (48 h) higher NLR values were associated new atrial fibrillation in patients undergoing CABG 20. Another study in patients undergoing transcatheter aortic valve replacement showed that higher increase in NLR after valve implantation was associated with worse survival 21. Of note, baseline NLR in the same study was not associated with survival.…”

Section: Discussionmentioning

confidence: 98%

“…On the contrary, other studies have showed better NLR AUC for mortality both in HF 28,29 and in non-ST elevation myocardial infarction. 30 The results for PLR were different, and most studies have showed a better predictive value in ST elevation myocardial infarction, [13][14][15] HF, 28,29 and transcatheter aortic valve replacement, 21 and after percutaneous coronary interventions 26 or after implantable cardioverter defibrillator placement. 18 Of note, only few studies analysed the predictive value of PLR for mortality, and most showed predictive value in surrogate endpoints.…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

et al. 2017

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AimsThe aim of this study was to evaluate whether neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) predict outcome in heart failure (HF) patients undergoing heart transplantation (HTX).Methods and resultsData from 111 HF patients undergoing HTX 2010–2015 were retrospectively reviewed. NLR and PLR were calculated before HTX, immediately after HTX, and at 6 and 24 hours. Primary endpoint was in‐hospital mortality, and secondary endpoints were 1 year mortality and renal replacement therapy (RRT). Prognostic factors were assessed by multivariate analysis, and the predictive values of NLR and PLR for mortality were compared. The discriminatory performance for predicting in‐hospital mortality was better for NLR [area under the receiver operating characteristic curve (AUC) = 0.644, 95% confidence interval 0.492–0.797] than for PLR (AUC = 0.599, 95% confidence interval 0.423–0.776). Best cut‐off value was 2.41 for NLR (sensitivity 86%, specificity 67%) and 92.5 for PLR (sensitivity 86%, specificity 68%). When divided according to best cut‐off value, in‐hospital mortality was significantly higher in the high NLR group (17.5% vs. 3.2%, P < 0.05), but not in the high PLR group (16.5% vs. 6.3%, P = ns). One year mortality was not significantly higher for either group (37.5% vs. 6.5% for NLR; 36.7% vs. 9.4% for PLR, P = ns for both), while RRT was significantly higher in both the NLR and PLR high groups (33.8% vs. 0%; 32.9% vs. 3.1%, respectively, P < 0.001). Multivariate analysis indicated that only high NLR (hazard ratio = 3.403, P < 0.05) and pre‐transplant diabetes (hazard ratio = 3.364, P < 0.05) were independent prognostic factors for 1 year mortality.ConclusionsHigh NLR was a predictor for in‐hospital mortality, and an independent prognostic factor for 1 year mortality. Both high NLR and high PLR were predictors for RRT.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

et al. 2017

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“…Condado, et al [24] reported that an elevated NLR is correlated with occurrence of the composite early safety outcome at 30 days in patients who undergo balloon expandable TAVI. A high variation in the NLR from baseline to discharge is correlated with a higher 1-year survival and lower mortality.…”

Section: Overall (N ═ 97)mentioning

confidence: 99%

The Impact of Transcatheter Aortıc Valve Implantatıon on Neutrophıl to Lymphocyte Ratıo: A Retrospective Study

Afşin¹,

Kavalcı²,

Ulutaş³

et al. 2019

Int J Clin Cardiol

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Background: Transcatheter aortic valve implantation (TAVI) has become a novel therapeutic option for patients with severe aortic stenosis who have been considered inoperable or high risk for conventional surgical aortic valve replacement. The aim of this study was to determine the effect of TAVI on neutrophil to lymphocyte ratio (NLR). Methods: A total of 97 patients with severe aortic valve stenosis undergoing TAVI in our clinic were included in the study. The patients were divided into two groups based on valve type; patients with CoreValve bioprosthesis (n = 56) and patients with Edwards SAPIEN-XT bioprosthesis (n = 41). Blood samples were drawn before TAVI and were performed at 1 and 6 months after TAVI. Results: The patients in the Edwards SAPIEN group were older than the patients in the CoreValve group (76.7 ± 6.6 years, p = 0.019). Eurologistic score (p = 0.002), choronic obstructive pulmonary disease (p = 0.006), and pulmonary arterial pressure-systole (p = 0.001) were significantly higher in patients in the CoreValve group than those in the Edwards SAPIEN group. Aortic valve area had increased in both groups after the procedure (p < 0.001 and p < 0.001, respectively). In addition, interventricular septal wall thickness, posterior wall thickness, and left ventricular mass index regressed in both groups at 6 month follow-up (p < 0.001, p < 0.001, and p < 0.001, respectively). When compared with the baseline NLR, a significant decrease was observed in the values at 1 and 6 months in both groups (p < 0.001 and p < 0.001, respectively). Conclusions: A decrease in the NLR can be both a sign of regression of valvular inflammation and myocardial hypertrophy in patients with degenerative aortic stenosis after TAVI. Our results show that it may be used during the follow-up of patients with TAVI.

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“…Therefore, DR is also classified as a chronic inflammatory disease [6]. Neutrophil-to-lymphocyte ratio (NLR), monocyte-tolymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) have been proven to be potential inflammatory markers in various conditions, including tumors [7][8][9][10], cardiovascular diseases [11,12], and other diseases [13]. Some studies have also reported that PLR and NLR are associated with diabetes and its complications [14].…”

Section: Introductionmentioning

confidence: 99%

Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Patients with Diabetic Macular Edema Treated with Ranibizumab

Cheng

et al. 2019

Preprint

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Background: To investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in patients with diabetic macular edema (DME) treated monthly with ranibizumab. Methods: We retrospectively analyzed the medical records of all patients who received intravitreal ranibizumab (IVR) treatment for DME at the First Affiliated Hospital of Nanchang University between December 2015 and December 2017. Clinicopathological parameters, including NLR, were evaluated to identify predictors of better outcomes of IVR monotherapy. Results: Ninety-one treatment-naïve eyes treated with IVR for DME were retrospectively analyzed in this study. Baseline best-corrected visual acuity (BCVA), neutrophils, NLR, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were negatively correlated with the changes in BCVA at 24 weeks compared with the baseline, while baseline central retinal thickness and lymphocytes were positively correlated with the changes in BCVA at 24 weeks compared with the baseline. Multiple linear regression analysis revealed that NLR was independently associated with the mean change of BCVA between baseline and week 24. In addition, patients with NLR < 2.27 showed a better improvement in letter score than those with NLR > 2.27. Conclusion: Pretreatment NLR is independently associated with the BCVA in DME patients treated with IVR, and higher pretreatment NLR may contribute to inferior BCVA outcomes.

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Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) can risk stratify patients in transcatheter aortic-valve replacement (TAVR)

Cited by 49 publications

References 17 publications

Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

Neutrophil‐to‐lymphocyte ratio and platelet‐to‐lymphocyte ratio as predictors of survival after heart transplantation

The Impact of Transcatheter Aortıc Valve Implantatıon on Neutrophıl to Lymphocyte Ratıo: A Retrospective Study

Pretreatment Neutrophil-to-Lymphocyte Ratio Predicts Prognosis in Patients with Diabetic Macular Edema Treated with Ranibizumab

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