Neutrophil–lymphocyte ratio may predict in-hospital mortality in patients with acute type A aortic dissection

Karakoyun, Süleyman; Gürsoy, Mustafa Ozan; Akgün, Taylan; Öcal, Lütfi; Kalçık, Macit; Yesi̇n, Mahmut; Erdoğan, Emrah; Külahçıoğlu, Şeyhmus; Bakal, Ruken Bengi; Köksal, Cengiz; Yıldız, Mustafa; Özkan, Mehmet

doi:10.1007/s00059-014-4121-2

Cited by 28 publications

(25 citation statements)

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“…Previous studies have demonstrated the neutrophil/lymphocyte ratio (NLR) to be a good predictor of inhospital mortality [6,11,29]. In Karakoyun et al's study [11], they found that an NLR >8.51 yielded an AUC value of 0.829. In our study, however, LNR was not a significant independent predictor of 30-day mortality in AAAD patients, and the diagnostic value of an AUC could only reach 0.589.…”

Section: Discussionmentioning

confidence: 99%

“…Both lymphocyte to monocyte ratio (LMR) and lymphocyte to neutrophil ratio (LNR), obtained from routine blood tests at admission, are readily available inflammatory biomarkers [8,9]. Previous studies have found that LMR and LNR both were good predictors of worse outcomes in patients with AAAD [10,11]. However, the comparative predictive values of LMR and LNR are unclear.…”

Section: Introductionmentioning

confidence: 99%

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Relationship of Platelet Counts and Inflammatory Markers to 30-Day Mortality Risk in Patients with Acute Type A Aortic Dissection

Lin

Zhang

Peng

et al. 2020

BioMed Research International

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Markers of prothrombotic state and inflammation are associated with the prognosis of patients with acute type A aortic dissection (AAAD). However, it is unclear that the relationship between these biomarkers and their combined impact on risk stratification. The present study evaluated the prognostic value of platelet counts, lymphocyte to neutrophil ratio (LNR), and lymphocyte to monocyte ratio (LMR), alone and in combination. A retrospective analysis of clinical data of 744 AAAD patients was conducted to identify whether these biomarkers were related to the 30-day mortality risk. A Kaplan-Meier analysis and log-rank test were used to compare survival between groups. A Cox hazard regression multivariable analysis was performed for 30-day mortality. Individual biomarker (platelet count, LNR, or LMR) was unable to predict 30-day mortality. However, combinations of all three biomarkers provided additive predictive value over either marker alone, the receiver operating characteristic (ROC) model had a prediction probability of 0.739 when platelet counts, LNR, and LMR were included. Cox hazard regression multivariable analysis showed that combinations of all three biomarkers were the strongest predictor of 30-day mortality (p<0.021). Combined with these three easily measurable biomarkers at admission, they could help identify AAAD patients with a high risk of 30-day mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship of Platelet Counts and Inflammatory Markers to 30-Day Mortality Risk in Patients with Acute Type A Aortic Dissection

Lin

Zhang

Peng

et al. 2020

BioMed Research International

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“…The NLR is the comprehensive presentation of systemic in ammation and the balance between neutrophils and lymphocytes in CBCs. Previous studies have shown that an elevated NLR is associated with an increased rate of hospital mortality among patients with acute pulmonary embolism [13], acute exacerbation of chronic obstructive pulmonary disease [21], and acute type A aortic dissection [22]; of 30-day mortality among patients with acute pulmonary embolism [19], acute kidney injury [23], ST-elevation myocardial infarction [24], and intracerebral hemorrhage [25,26]; and of long-term mortality among patients with STelevation myocardial infarction [27], breast cancer [28] and epithelial ovarian cancer [29].…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of the preoperative neutrophil-to-lymphocyte ratio and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism

Liu

Zhan

Huang

et al. 2020

Preprint

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Background: This retrospective study aimed to investigate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism (PAPE).Methods: We retrospectively reviewed the medical records of 101 patients with PAPE admitted from September 1, 2012, to March 31, 2019. The characteristics, surgical information, admission examination data and mortality within 30 days after PAPE were obtained from our electronic medical recording system and follow-up. The associations between the NLR, PLR, and other predictors and 30-day mortality were analyzed with univariate and multivariate analyses. Then, the nomogram including the independent predictors was established and evaluated.Results: Twenty-four patients died within 30 days, corresponding to a 30-day mortality rate of 23.8%. The results of the multivariate analysis indicated that both the NLR and albumin were independent predictors for 30-day mortality in patients with PAPE. The probability of death increased by approximately 17.1% (OR=1.171, 95% CI: 1.073–1.277, P=0.000) with a one-unit increase in the NLR, and the probability of death decreased by approximately 15.4% (OR=0.846, 95% CI: 0.762c–0.939, P=0.002) with a one-unit increase in albumin. The area under the curve of the nomogram was 0.888 (95% CI: 0.812-0.964).Conclusion: Our findings showed that an elevated NLR and decreased albumin were related to poor prognosis in patients with PAPE. The NLR and albumin were independent prognostic factors for PAPE.

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“…NLR is the comprehensive presentation of systemic inflammation and the balance between neutrophils and lymphocytes in CBC. Previous studies have showed that the elevated NLR is associated with increased rate of hospital mortality among patients with acute pulmonary embolism [13], AECOPD [18], and acute type A aortic dissection [19] [27].…”

Section: Discussionmentioning

confidence: 99%

Prognostic role of preoperative neutrophil-to-lymphocyte ratio and albumin for 30-days mortality in patients with postoperative acute pulmonary embolism

Liu

Zhan

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background This retrospective study aimed to investigate the prognostic value of neutrophil–lymphocyte ratio (NLR) and albumin in 30-days mortality in patients with postoperative acute pulmonary embolism (PAPE).Methods We retrospectively reviewed the medical records of 101 patients with PAPE admitted from September 1, 2012 to March 31, 2019. The characteristics, surgical information, admission examination data and mortality within 30-days after PAPE were obtained from our electronic medical recording system and follow up. The association between NLR, PLR, and other predictors and 30-days mortality were analyzed with univariate and multivariate analyses. Then, the nomogram include the independent predictors was established and evaluated.Results 24 patients died within 30 days corresponding to 30-days mortality of 23.8%. The results of the multivariate analysis indicated that both NLR and albumin are independent predictors for 30-days mortality in patients with PAPE. The probability of death increased about 17.1% (OR=1.171, 95% CI: 1.073–1.277, P=0.000) with one unit of increase of NLR, and the probability of death decreased about 15.4% (OR=0.846, 95% CI: 0.762c–0.939, P=0.002) with one unit of increase of albumin. The area under the curve of nomogram was 0.888(95%CI:0.812-0.964).Conclusion Our findings showed that Elevated NLR and decreased albumin were related with poor prognosis in patients with PAPE. The NLR and albumin were independent prognostic factor for PAPE.

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Neutrophil–lymphocyte ratio may predict in-hospital mortality in patients with acute type A aortic dissection

Abstract: The novel inflammatory marker NLR could be used to predict pericardial effusion and in-hospital mortality in patients with acute AD type A.

Cited by 28 publications

References 28 publications

Relationship of Platelet Counts and Inflammatory Markers to 30-Day Mortality Risk in Patients with Acute Type A Aortic Dissection

Relationship of Platelet Counts and Inflammatory Markers to 30-Day Mortality Risk in Patients with Acute Type A Aortic Dissection

Prognostic role of the preoperative neutrophil-to-lymphocyte ratio and albumin for 30-day mortality in patients with postoperative acute pulmonary embolism

Prognostic role of preoperative neutrophil-to-lymphocyte ratio and albumin for 30-days mortality in patients with postoperative acute pulmonary embolism

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