Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography

Arbel, Yaron; Finkelstein, Ariel; Halkin, Amir; Birati, Edo Y.; Revivo, Miri; Zuzut, Meital; Shevach, Ayala; Berliner, Shlomo; Herz, Itzhak; Keren, Gad; Banai, Shmuel

doi:10.1016/j.atherosclerosis.2012.09.009

Cited by 313 publications

(278 citation statements)

References 26 publications

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“…Previous studies have reported that NLR was related to the development and progression of CAD (5,22). In the present study, the percent diameter stenosis was significantly greater and total atheroma volume was significantly greater in patients with high NLR compared with those with low NLR.…”

Section: Discussionsupporting

confidence: 67%

“…Also NLR provides a simple and inexpensive method for assessment of inflammatory status in patients with acute coronary syndrome (4). Several studies have demonstrated a relation between the NLR and the severity of atherosclerosis and clinical outcome (5)(6)(7)(8)(9)(10)(11). However, the virtual histology-intravascular ultrasound (VH-IVUS) findings according to NLR were not well known.…”

Section: Introductionmentioning

confidence: 99%

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Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

Choi

Hong

Jeong

et al. 2013

The American Journal of Cardiology

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

Choi

Hong

Jeong

et al. 2013

The American Journal of Cardiology

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“…NLR has been shown to be an independent prognostic factor in various solid tumours, including lung, colorectal, pancreatic, breast, ovarian and gastric cancer [25][26][27][28][29][30]. Furthermore, it has been associated with disease severity, hospitalisation, malnutrition, recurrences and mortality in various chronic diseases, including cardiovascular and kidney diseases [31][32][33]. In recent years, the NLR has also been investigated as diagnostic and prognostic marker in COPD.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

et al. 2018

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Chronic obstructive pulmonary disease (COPD) is a disabling condition that is characterised by poorly reversible airflow limitation and inflammation. Acute exacerbations of COPD are a common cause of hospitalisation and death among COPD patients. Several biochemical markers have been studied as outcome predictors in COPD; however, their measurement often requires significant time and resources. Relatively simple biomarkers of inflammation calculated from routine complete blood count tests, such as the neutrophil to lymphocyte ratio (NLR), might also predict COPD progression and outcomes. This review discusses the available evidence from studies investigating the associations between the NLR, COPD exacerbations and death in this patient group.

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“…The prognostic significance of PBC-derived ratios in patients with different primary tumors as well as patients affected with non-neoplastic disorders has been reported in numerous prior studies [16][17][18][19][20][29][30][31][32][33][34][35]. It has been demonstrated that serum or urinary concentrations of neopterin represent a valuable biomarker in cancer patients as well as in patients with atherosclerosis [3,4,6].…”

Section: Discussionmentioning

confidence: 99%

Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

et al. 2017

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Abstract:In the present study, we determined complex indices of inflammatory activity and compared the performance of these indices as prognostic biomarkers in a cohort of breast cancer patients. All proposed composite biomarkers could be evaluated in 418 out of 474 patients in the cohort with complete data on peripheral blood cell count, urinary neopterin, albumin and C-reactive protein. Neutrophil-to-lymphocyte ratio, lymphocyteto-monocyte ratio, platelet-to-lymphocyte ratio, systemic inflammatory index, Glasgow prognostic index, modified Glasgow prognostic index, prognostic nutritional index and C-reactive protein/albumin ratio were calculated and further complex indices were proposed. Although a number of the investigated indices were significantly associated with survival in the univariate analysis, only age and stage, but none of the laboratory biomarkers or composite biomarkers, were significant predictors of survival in the whole group in the multivariate analysis. In patients evaluated before the start of the treatment, age, stage and urinary neopterin were significant predictors of survival. These results underscore the importance of neopterin as a prognostic biomarker in breast cancer.

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Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography

Cited by 313 publications

References 26 publications

Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

Relationship Between Neutrophil-To-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology-Intravascular Ultrasound Analysis

Neutrophil to lymphocyte ratio and clinical outcomes in COPD: recent evidence and future perspectives

Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

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