Neutrophil-lymphocyte ratio, high-sensitivity C-reactive protein and monocyte chemoattractant protein-1 as novel markers for patients with type 2 diabetic kidney disease

Abstract

Objective To investigate the value of inflammatory markers including neutrophil-lymphocyte ratio (NLR), high-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1) in the prediction of type 2 diabetic kidney disease (T2DKD). Materials and methods This study used a cross-sectional survey research method. A total of 90 patients with type 2 diabetes mellitus (T2DM) were included and divided into three groups (A1, A2, A3) according to the urinary albumin-to-creatinine ratio (UACR). Observe and compare the basic information, clinical and laboratory data, and the inflammatory markers NLR, hs-CRP, MCP-1. Results High levels of NLR (OR=6.562, 95%CI 2.060-20.902, P=0.001) and MCP-1 (OR=1.060, 95%CI 1.026-1.095, P<0.001) were risk factors in the development of T2DKD. Receiver operating characteristic curve analysis showed that the area under curve of NLR and MCP-1 in diagnosing T2DKD were 0.760 (95%CI 0.6577-0.863, P < 0.001) and 0.862 (95%CI0.7787-0.937, P < 0.001). Conclusion The inflammatory markers NLR and MCP-1 are risk factors affecting the development of T2DKD, which of clinical value may be used as novel markers of T2DKD.