Neutrophil–Lymphocyte Ratio Connected to Treatment Options and Inflammation Markers of Ankylosing Spondylitis

Gökmen, Ferhat; Akbal, Ayla; Reşorlu, Hatice; Gökmen, Esra; Güven, Mustafa; Aras, Adem Bozkurt; Erbağ, Gökhan; Kömürcü, Erkam; Akbal, Erdem; Çoşar, Murat

doi:10.1002/jcla.21768

Cited by 69 publications

(71 citation statements)

References 10 publications

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“…Expectedly, ESR and CRP values were shown to have good correlation with disease activity of AS patients in this study similar to previous studies. 6,17,19 In addition, NLR was shown to be correlated weakly but significantly with BASDAI scores of AS patients in this study similar to a previous study by Gökmen et al 17 These results likely indicate that NLR may be a parameter to measure disease activity in AS.…”

Section: Discussionsupporting

confidence: 89%

“…4,[6][7][8] On the other hand, NLR has been proposed to be a marker to evaluate systemic inflammatory condition in various chronic inflammatory diseases. [10][11][12][13][14][15][16][17] However, the relationship between disease activity in AS and NLR has not been fully demonstrated yet. NLR is also an objective measurement and does not lead to any additional cost to the patients.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 Recently, neutrophil-lymphocyte ratio (NLR) has been calculated to evaluate inflammation in various chronic inflammatory diseases such as coronary chronic total occlusion, 10 psoriasis, 11 chronic kidney disease, 12 ulcerative colitis, 13 gastric cancer, 14 chronic obstructive pulmonary disease, 15 familial Mediterranean fever, 16 and AS. 17 In addition, mean platelet volume (MPV) was reported to have a predictive value of inflammation in chronic obstructive pulmonary disease, 15 inflammatory bowel disease, 18 rheumatoid arthritis (RA) and AS. [19][20][21] On the other hand, platelet-lymphocyte ratio (PLR) was also suggested to be an inflammatory marker, and shown to be a valuable prognostic marker in several malignancies such as gastric, 14 colon, 22 and non-small cell lung cancers.…”

mentioning

confidence: 99%

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May Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios Indicate Disease Activity in Ankylosing Spondylitis?

et al. 2015

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Objectives:This study aims to evaluate the associations between neutrophil-lymphocyte ratio (NLR), mean platelet volume, and plateletlymphocyte ratio (PLR) with disease activity in ankylosing spondylitis. Patients and methods:The study included 103 patients (63 males, 40 females; mean age 40.7±12.0 years; range 20 to 70 years) with ankylosing spondylitis and 70 healthy controls (43 males, 27 females; mean age 42.7±15.3 years; range 18 to 66 years). All participants' age, sex, erythrocyte sedimentation rate, C-reactive protein and mean platelet volume levels, total white blood cell, neutrophil, lymphocyte, and platelet counts were recorded while patients' Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index and Bath Ankylosing Spondylitis Metrology Index scores, medication types, duration of disease and medication use were recorded. Patients were divided into three groups: healthy controls (group 1), patients having BASDAI scores <4 with mild disease activity (group 2, n=73), and patients having BASDAI scores ≥4 with moderate-severe disease activity (group 3, n=30). NLR and PLR values were calculated. Results: Counts of neutrophil, NLR, C-reactive protein levels and PLR were significantly higher in group 3 compared to groups 1 and 2 (p<0.05). BASDAI scores were correlated weakly with neutrophil counts, NLR and PLR, and correlated moderately with C-reactive protein and erythrocyte sedimentation rate (p<0.05). Conclusion: Our study results indicate that, in ankylosing spondylitis, mean platelet volume is not associated with disease activity, whereas NLR and PLR may reflect disease activity.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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May Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios Indicate Disease Activity in Ankylosing Spondylitis?

et al. 2015

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“…Like these studies, Gokmen et al were sad, NLR may be seen as a useful marker for demonstrating inflammation together with acute phase reactants such as C-reactive protein in ankylosing spondylitis [11].…”

Section: Discussionmentioning

confidence: 92%

“…This marker is cheap, readily accessible and can be calculated quite easily. Recently, neutrophil/lymphocyte ratio (NLR) has been shown to reflect inflammatory burden in some acute inflammatory diseases like to AA [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Change of Neutrophil Lymphocyte Ratio in Acute Appendicitis

Küçük¹

2015

Med-Science

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Neutrophil‐to‐Lymphocyte Ratio and Platelet‐to‐Lymphocyte Ratio as Biomarkers in Axial Spondyloarthritis: Observational Studies From the Program to Understand the Longterm Outcomes in Spondyloarthritis Registry

Sen¹,

Kim²,

Napier

et al. 2022

Arthritis & Rheumatology

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Objectives This study was conducted to assess the utility of neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR) in predicting radiographic sacroiliitis and active disease in axial spondyloarthritis (SpA) and to explore the association between use of a tumor necrosis factor inhibitor (TNFi) and these laboratory values compared with traditional inflammatory markers. Methods Observational data from the Program to Understand the Longterm Outcomes in Spondyloarthritis (PULSAR) registry were analyzed. We generated receiver operating characteristic curves to calculate laboratory cutoff values; we used these values in multivariable logistic regression models to identify associations with radiographically confirmed sacroiliitis and active disease. We also used logistic regression to determine the likelihood of elevated laboratory values after initiation of TNFi. Results Most study participants (n = 354) were White, male, and HLA–B27 positive. NLR (odds ratio [OR] 1.459, P = 0.034), PLR (OR 4.842, P < 0.001), erythrocyte sedimentation rate (OR 4.397, P < 0.001), and C‐reactive protein (CRP) level (OR 2.911, P = 0.001) were independent predictors of radiographic sacroiliitis. Models that included PLR with traditional biomarkers performed better than those with traditional biomarkers alone. NLR (OR 6.931, P = 0.002) and CRP (OR 2.678, P = 0.004) were predictors of active disease, but the model that included both NLR and CRP performed better than CRP alone. TNFi use reduced the odds of elevated NLR (OR 0.172, P < 0.001), PLR (OR 0.073, P < 0.001), erythrocyte sedimentation rate (OR 0.319, P < 0.001), and CRP (OR 0.407, P < 0.001), but models that included NLR or PLR and traditional biomarkers performed best. Conclusions These findings demonstrate an association between NLR and PLR and sacroiliitis and disease activity, with NLR and PLR showing response after TNFi treatment and adding useful clinical information to established biomarkers, thus perhaps assisting in management of axial SpA.

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Neutrophil–Lymphocyte Ratio Connected to Treatment Options and Inflammation Markers of Ankylosing Spondylitis

Abstract: NLR may be seen as a useful marker for demonstrating inflammation together with acute phase reactants such as CRP and in evaluating the effectiveness of anti-TNF-α therapy.

Cited by 69 publications

References 10 publications

May Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios Indicate Disease Activity in Ankylosing Spondylitis?

May Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios Indicate Disease Activity in Ankylosing Spondylitis?

The Change of Neutrophil Lymphocyte Ratio in Acute Appendicitis

Neutrophil‐to‐Lymphocyte Ratio and Platelet‐to‐Lymphocyte Ratio as Biomarkers in Axial Spondyloarthritis: Observational Studies From the Program to Understand the Longterm Outcomes in Spondyloarthritis Registry

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