Neutrophil/lymphocyte ratio: Can a non-specific marker of inflammation helps to confirm the inflammatory hypothesis of the serious mental diseases? A case-control study

Rodríguez, Josefina Flores; Fernández, José Díaz; Mira, Nieves Orta; López-Briz, Eduardo; Gómez-Pajares, Fernando

doi:10.1016/j.mehy.2019.109279

Cited by 9 publications

(8 citation statements)

References 31 publications

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“…Another recent meta-analysis identified 11 studies exploring NLR, PLR, MLR in non-affective psychosis has shown that NLR an d MLR higher in patients than control group 36 . So predominantly NLR seems to be more reliable inflammatory markers in severe mental disorders 18 .…”

Section: Discussionmentioning

confidence: 97%

“…Subclinical inflammation has been described in also mental disorders like major depressive disorder, bipolar disorder, schizophrenia and schizoaffective disorder which can be presented with catatonia [15][16][17] . Recent studies support this inflammation hypothesis in severe mental disorders 18 . In fact, the evidence of subclinical inflammation presence in mental disorders that do not exhibit catatonic features is also prominent [19][20][21] .…”

Section: Introductionmentioning

confidence: 83%

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Neutrophil-lymphocyte ratio in catatonia

Şahin

Yaşamali

Özyürek

et al. 2020

Arch. Clin. Psychiatry (São Paulo)

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 83%

Neutrophil-lymphocyte ratio in catatonia

Şahin

Yaşamali

Özyürek

et al. 2020

Arch. Clin. Psychiatry (São Paulo)

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“…When comparing patients with initial episode and recurrent depressive attacks, NLR values were higher in the first episode patients. In addition, Rodriguez et al concluded that inflammatory processes play a role in patients with psychotic disorders (27). NLR is the best marker to assess these disorders.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Peripheral Inflammation Parameters in Adolescents With Suicide Attempts

Kara

Bağcı²

2022

Kocatepe Tıp Dergisi

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AMAÇ: Hematolojik parametreler, psikopatoloji ve inflamasyon arasındaki ilişkiyi göstermek için kullanılabilen periferik inflamasyon belirteçleridir. Bu çalışmada intihar girişiminde bulunan ergenleri sağlıklı ergenlerle hematolojik parametreler açısından karşılaştırmayı amaçladık.GEREÇ VE YÖNTEM: Ekim 2018 - Mart 2020 tarihleri arasında Çocuk Acil Servisine başvuran 765 ergenin hemogram kayıtları geriye dönük olarak değerlendirildi. Kontrol grubu, benzer yaş ve cinsiyet özelliklerine sahip, yukarıda belirtilen dönemde çocuk hastalıkları polikliniğinde muayene edilen, organik veya psikopatolojik herhangi bir tanısı olmayan ergenlerin hemogram kayıtlarından oluşturuldu. Dışlama kriterleri uygulandıktan sonra intihar girişimi olan 95 vaka ve 95 kontrol grubu çalışmaya dahil edildi. Vaka ve kontrol grupları istatistiksel olarak nötrofil/lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR), monosit/lenfosit oranı (MLR), ortalama trombosit hacmi (MPV) ve eritrosit dağılım genişliği (RDW) parametreleri açısından karşılaştırıldı.BULGULAR: İntihar girişimi olan ergenlerde NLR ve MLR değerleri kontrol grubuna göre anlamlı olarak yüksek saptandı. Diğer parametreler açısından gruplar arasında istatistiksel olarak anlamlı bir fark saptanmadı. NLR ve MLR parametreleri açısından ek psikiyatrik tanılara göre ayrılan olgu grubunun üç alt grubu arasında istatistiksel olarak fark yoktu. Ancak NLR, bu üç alt grupta kontrol grubuna göre anlamlı olarak daha yüksek bulundu.SONUÇ: İntihar girişiminde bulunan ergenlerin NLR ve MLR parametreleri kontrol grubuna göre daha yüksek saptandı. İntihar girişimi olan ergenlerde inflamatuar parametrelerin değerlendirilmesi ile ilgili daha kapsamlı araştırmalara ihtiyaç vardır.

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“…A higher total white cell count and neutrophil count but a lower lymphocyte count were observed in the FEP patients in our study. It is worth noting that lymphocyte count comparisons varied across different studies [37][38][39][40], and the mixed ndings might re ect the complex relationships between lymphocyte level and the clinical status, such as symptom severity, illness chronicity, and treatment status, as shown in an earlier meta-analysis [41]. An increase in neutrophil counts and a decrease in lymphocyte counts in other diseases might re ect an overall enhanced in ammatory intensity and an impaired immune system, respectively [42].…”

Section: Discussionmentioning

confidence: 99%

Altered Neutrophil-to-Lymphocyte Ratio in Patients with Non-Affective First Episode Psychosis and its Relationship with Symptom Severity and Cognitive Impairment

Leung

Wong

Shea

et al. 2022

Preprint

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Signatures of immune dysregulation as clinical biomarker for psychosis have remained unclear. We aimed to compare the Neutrophil-to-lymphocyte ratio (NLR) of patients with acute non-affective first-episode psychosis (FEP) with healthy controls after accounting for emotional states, and explore their associations with symptom severity, onset profile and cognitive functions. The NLR was enumerated from complete blood count taken within a week of assessment. All FEP patients were assessed with Positive and Negative Syndrome Scale (PANSS) and the Clinician Global Impression-Severity (CGI-S) scores. Verbal memory and executive functions were assessed with the Cambridge Neuropsychological Test Automated Battery. Prevailing emotional state was measured with Beck Depression Inventory-II and Beck Anxiety Inventory. 27 eligible subjects screened out of 79 consecutive FEP patients with their age-/sex-matched controls were recruited. The FEP patients had an NLR of 1.886 higher than controls after accounting for emotional states. The NLR of FEP patients was positively associated with PANSS positive symptom, disorganization and excitation scores, as well as CGI-S scores. There was no significant correlation between NLR with duration of untreated psychosis and cognitive performances. These findings support using NLR as clinical biomarker in FEP, purporting further prospective study to measure NLR changes in the course of treatment.

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Neutrophil/lymphocyte ratio: Can a non-specific marker of inflammation helps to confirm the inflammatory hypothesis of the serious mental diseases? A case-control study

Cited by 9 publications

References 31 publications

Neutrophil-lymphocyte ratio in catatonia

Neutrophil-lymphocyte ratio in catatonia

Evaluation of Peripheral Inflammation Parameters in Adolescents With Suicide Attempts

Altered Neutrophil-to-Lymphocyte Ratio in Patients with Non-Affective First Episode Psychosis and its Relationship with Symptom Severity and Cognitive Impairment

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