Neutrophil-lymphocyte ratio as a prognostic factor in colorectal cancer

Abstract

Pre-operative NLR may represent a simple method of identifying colorectal cancer patients with a poor prognosis pre-operatively.

Red Cell Distribution Width as a Predictor of Prostate Cancer Progression

“…Several studies suggested that the neutrophilto-lymphocyte ratio was a prognostic factor for colorectal and non-small cell cancer. Other studies revealed that the neutrophil-to-lymphocyte ratio was related to poor prognosis (Walsh et al, 2005;). The results of the current study suggest that the presence of a systemic inflammatory reaction at diagnosis was an independent predictor of poor long-term cancer outcomes in patients with localized prostate cancer (McArdle et al, 2010).…”

Pretreatment Neutrophil/Lymphocyte Ratio as a Prognostic Aid in Colorectal Cancer

“…Pre-treatment elevated NLR was first described by Walsh et al (2005) as a useful prognostic indicator in CRC. After that, emerging evidences from several studies have pointed out that NLR has a prognostic value in patients with pancreatic (Aliustaoglu et al, 2010), breast (Azab et al, 2012), lung (Kaya et al, 2013;Unal et al, 2013) and gastric (Jung et al, 2011) cancers.…”

“…On the other hand some reports have studied different stages like we did, while others analyzed specific stage of patients in terms of survival analysis. Ding et al (2010) studied only stage IIA patient; on the contrary Walsh et al (2005) studied all Dukes stages patients. Additionally, Halazun et al (2008) found that elevated NLR increases both risk of death and the risk of recurrence in patients who undergo surgery for CRC liver metastases.…”

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

“…[158] Colorectal cancer The NLR was higher in advanced stages of cancer. The ability to produce ROS at the terminal stage was 33 % lower than in the control group.…”