Neutrophil-lymphocyte ratio as a predictive factor for tumor staging in colorectal cancer

Özgehan, Gülay; Kahramanca, Şahin; Kaya, İsmail; Bilgen, Köksal; Bostancı, Hasan; Güzel, Hatice; Küçükpınar, Tevfik; Kargıcı, Hülagü

doi:10.3906/sag-1305-33

Cited by 19 publications

(23 citation statements)

References 13 publications

(12 reference statements)

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“…Only few groups have investigated the role of NLR in predicting colorectal tumour staging. Previous studies have found elevated NLR to be significantly associated with advanced TNM stages and similar to our findings, Özgehan et al [38] reported significant differences in NLR between the N1/N2 and N0 stage (mean: 6.597 vs. 4.501, respectively, p < 0.001), whilst Malietzis et al [39] reported an increased number of patients with N1/N2 stage in a higher NLR group [79 (28.9%) vs. 45 (19.7%), p = 0.039]. Similarly, Ishizuka et al [40] reported a higher frequency of nodal involvement in patients with elevated NLR and platelet counts.…”

Section: Discussionsupporting

confidence: 82%

The Neutrophil-to-Lymphocyte Ratio as a Marker of Lymph Node Status in Patients with Rectal Cancer

Khan

Akritidis²,

Pring³

et al. 2016

Oncology

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Aim: The aim of the study was to investigate the role of the neutrophil-to-lymphocyte ratio (NLR) as a prognostic marker of rectal cancers. Methods: We undertook a retrospective review of patients with rectal cancer. Pre-treatment NLR was assessed for association and predictive values against clinicopathological staging and post-treatment outcomes. Results: A total of 140/180 cases were included in the final analysis [male:female 2:1; mean age 68 years (interquartile range 58-75)]. The pre-operative mean NLR was 5.4 ± 6.8. There was a strong positive correlation between NLR and C-reactive protein (Spearman's rho 64.3%, p < 0.001). A high NLR was associated with a positive nodal status on MRI (5.2 vs. 3.8, p = 0.03) and histopathological (4.8 vs. 3.8, p = 0.02) assessment. The NLR showed an average value for predicting MRI and pathological nodal status on receiver operating characteristic analysis [area under the curve = 0.72 (95% CI = 0.54-0.91), p = 0.031 and area under the curve = 0.64 (95% CI = 0.52-0.077), p = 0.021, respectively]. On multivariate analysis, the total lymph node retrieved at operation was the best predictor of pathological nodal involvement; NLR did not show any predictive value. Patients with an NLR >4 showed reduced recurrence-free (60 vs. 86 months, p = 0.52) and overall survival (57 vs. 84 months, p = 0.40) without statistical significance. Conclusion: Raised pre-treatment NLR may indicate nodal involvement in patients with rectal cancer.

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Section: Discussionsupporting

confidence: 82%

The Neutrophil-to-Lymphocyte Ratio as a Marker of Lymph Node Status in Patients with Rectal Cancer

Khan

Akritidis²,

Pring³

et al. 2016

Oncology

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“…In our review of the literature, we did not find any studies in which PLR predicted lymph node involvement in colon cancer. However, Özgehan et al 20 examined the effect of NLR on tumor staging in colon cancer and reported that NLR was significantly high in patients with lymph node positivity. This is important in that it demonstrates the importance of PLR, which is another inflammatory marker like NLR.…”

Section: Discussionmentioning

confidence: 99%

Clinical Value of Platelet-to-Lymphocyte Ratio in Predicting Liver Metastasis and Lymph Node Positivity of Colorectal Cancer Patients

Anuk¹,

Yıldırım²

2017

TJCD

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Amaç: Kolon kanserine bağlı mortalite azalsa da hala yüksektir. Kolonoskopinin artan kullanımı, cerrahi teknolojide ilerlemeler, kemoradyoterapi protokollerinin standardizasyonu metastatik olgularda sağkalımı arttırmıştır. Enflamasyon, birçok kanserin gelişiminde önemli rol oynar. Plateletlenfosit oranı (PLO) gibi birçok belirteç kanserde kötü prognoz ile ilişkilendirilmiştir. Çalışmamızda preoperatif bakılan PLO'nun kolon kanserli hastalarda karaciğer metastazını ve lenf nodu pozitifliğini öngörebilirliğini saptamayı amaçladık. Yöntem: Mart 2010 ve Eylül 2016 tarihleri arasında kolorektal kanser tanısı konularak operasyona alınan hastaların dosyaları retrospektif olarak incelendi. Hastaların demografik verileri, preoperatif PLO, intraoperatif bulgular ve postoperatif tümör-nod-metastaz evrelemesine göre histopatoloji raporları kaydedildi. Hastalar karaciğer metastazı saptananlar grup 1a ve saptanmayanlar grup 1b olarak 2 gruba ayrıldı. Aynı şekilde lenf nodu pozitifliği saptananlar grup 2a ve saptanmayanlar grup 2b olarak alt gruba ayrıldı. Sonuçlar SPSS programı ile analiz edildi. Bulgular: Yüz elli iki hastada erkek/kadın oranı 1,53 idi. En sık rektosigmoid bölgede kanser tespit edildi. Sekiz hastada ailesel kolorektal kanser, 66 hastada komorbid hastalık tespit edildi. Postoperatif 30 günlük dönemde sekiz hastada erken mortalite gözlendi. Otuz bir hastada karaciğer metastazı mevcuttu. PLO'nun gruplar arası karşılaştırmasında, metastaz saptanan grupta PLO değeri, anlamlı şekilde yüksekti (p<0,001). Yaş, cinsiyet ÖZ ABSTRACTAim: Colorectal cancer related mortality is still high. The widespread use of colonoscopy, surgical advancements, and standardized use of chemotherapeutic agents has increased survival rates in metastatic cases. Inflammation is the main etiological factor in a variety of cancers. Plateletto-lymphocyte ratio (PLR), one the most studied biochemical parameters, has been shown as a poor prognostic factor. In this study, our aim was to determine the predictive value of PLR on liver metastasis and lymph node positivity in colorectal patients. Method: The data of patients who were diagnosed with colorectal cancer and underwent surgery between March 2010 and September 2016 were analyzed retrospectively. Demographic characteristics, preoperative PLR, intraoperative findings, and tumor-node-metastasis stages were recorded. Patients with liver metastasis comprised group 1a and those without liver metastasis were group 1b; patients were also sorted into groups 2a and 2b based on lymph node positivity or negativity, respectively. Results: A total of 152 patients were included in the study and the male/female ratio was 1.53. Most of patients had rectosigmoid junction tumors. Eight patients had familial history of colorectal cancer and 66 patients had comorbid conditions. Eight patients had early 30-day mortality. Thirty-one patients had liver metastasis. Patients with liver metastasis (group 1a) had significantly higher PLR values when compared to group 1b (p<0.001). When age, gender and comorbid disease...

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“…Son yıllarda popüler olmaya başlayan özellikle çeşitli kanser tiplerinin sağ kalım sürelerinin tayin edilmesinde preoperatif dönemde elde edilen hematolojik parametrelerin preoperatif operabiliteyi veya metastatik hastalığı saptamakta faydalı olup olmayacağı araştırılmaya başlan-mıştır. Bu hematolojik parametreler içerisinde en sık çalışılanları nötrofil/lenfosit oranı (NLO), eritrosit dağılım genişliği (RDW) ve platelet/lenfosit oranıdır (PLO) [7][8][9] . RDW, kırmızı kan hücrelerinin (RBC) boyut ve hacim değişkenliğini gösteren ve anizositozu işaret eden parametredir.…”

Section: Girișunclassified

The Relation Between Preoperative Red Cell Distribution Width and Early Postoperative Mortality in Patients with Gastric Cancer

Özgehan¹,

Yıldırım²,

Imamoğlu³

et al. 2015

Kafkas J Med Sci

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AIM: In our study we aimed to investigate whether the preoperative red cell distribution width measurement can predict the early postoperative mortality within the fi rst 30 days in patients with gastric cancer. METHODS: The records of gastric cancer patients operated be GirișMide kanseri (MK) tüm dünyada kanser ölümlerinin en sık ikinci sebebidir. Tanı sırasında hastaların 2/3'ü tümörün rezeksiyonu için uygun değildirler 1 . Tanı ve tedavideki gelişmeler doğrultusunda mide kanserine bağlı ölüm oranları giderek azalmasına rağmen, halen

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Neutrophil-lymphocyte ratio as a predictive factor for tumor staging in colorectal cancer

Cited by 19 publications

References 13 publications

The Neutrophil-to-Lymphocyte Ratio as a Marker of Lymph Node Status in Patients with Rectal Cancer

The Neutrophil-to-Lymphocyte Ratio as a Marker of Lymph Node Status in Patients with Rectal Cancer

Clinical Value of Platelet-to-Lymphocyte Ratio in Predicting Liver Metastasis and Lymph Node Positivity of Colorectal Cancer Patients

The Relation Between Preoperative Red Cell Distribution Width and Early Postoperative Mortality in Patients with Gastric Cancer

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