Neutrophil–Lymphocyte Ratio and the Platelet–Lymphocyte Ratio Predict the Limb Survival in Critical Limb Ischemia

Taşoğlu, İrfan; Sert, Doğan Emre; Çolak, Necmettin; Uzun, Alper; Songür, Murat; Ecevit, Ata Niyazi

doi:10.1177/1076029613475474

Cited by 67 publications

(67 citation statements)

References 32 publications

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“…Gary et al proved that an increased PLR is significantly associated with patients at high risk for critical limb ischemia (CLI) and other cardiovascular endpoints [8]. By means of NLR and PLR CLI patients with a high risk for limb amputation during a five-year follow-up period were discriminated from patients with a lower risk for limb amputation during the same follow-up period [25]. NLR and PLR can be easily calculated as the neutrophils-tolymphocytes ratio and platelets-to-lymphocytes ratio in the peripheral blood and practical, inexpensive, and also valuable as high-cost inflammatory markers including IL-6, IL-1b, IL-8, and TNF-alpha.…”

Section: Discussionmentioning

confidence: 99%

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

Yi¹,

Oh²,

Choi³

et al. 2018

Korean J Otorhinolaryngol-Head Neck Surg

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Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-tolymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both < 0.001). The NLR value was 5.98±4.22 in the unrecovered group and 3.50±3.38 in the recovered group ( < 0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL ( = 0.001). Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.

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Section: Discussionmentioning

confidence: 99%

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

Yi¹,

Oh²,

Choi³

et al. 2018

Korean J Otorhinolaryngol-Head Neck Surg

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“…An increased PLR is associated with critical limb ischemia and vascular diseases such as atherosclerosis [15] . Durmuş et al [12] and Seo et al [6] observed that the PLR was significantly higher in adult patients with ISHL than in those in the healthy group.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte and Platelet-to- Lymphocyte Ratios in Pediatric Patients with Idiopathic Sudden Hearing Loss

Bulğurcu¹,

Dikilitaş²,

Arslan³

et al. 2017

Int Adv Otol

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“…Neutrophil and lymphocyte counts can be obtained from the leukocyte number in the complete blood count. NLR is considered a marker of inflammation and it is suggested that NLR has prognostic significance in some systemic disorders [7,8,19]. NLR is important as it provides information regarding two different pathways: 1) neutrophils resulting from ongoing inflammation; 2) lymphocytes in the regulatory pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Neutrophillymphocyte ratio (NLR) is a marker that can be estimated by using leukocyte subtypes from the complete blood count. Moreover, it has been reported that NLR may have prognostic value in some diseases [7,8].In the current literature, there is no study evaluating MPV and NLR together in gout. In this retrospective study, we investigated the role of MPV and NLR in the determining disease activity in gout disease.…”

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confidence: 99%

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Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

Balkarlı¹

2017

Ann Clin Anal Med

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ÖzetAmaç: Gut artmış ürik asit konsantrasyonu ile birlikte monosodyum ürat (MSU) kristallerine karşı oluşan inflamatuar yanıtın yol açtığı klinik bir sendromdur. Gut hastalığında inflamatuar yanıtın oluşmasında nötrofiller önem-lidir ve nötrofil aktivasyonu lokal olarak üretilen sitokinlere bağlıdır. Ortalama trombosit hacmi (MPV) ve nötrofil lenfosit oranı (NLR) bazı hastalıklarda inflamatuar belirteç olarak değerlendirilmiş ve prognostik öneme sahip olabileceği bildirilmiştir. Bildiğimiz kadarıyla literatürde gut hastalığında MPV ve/ veya N/L oranının değerlendirildiği bir çalışma yoktur. Biz bu retrospektif ça-lışmamızda gut hastalığında inflamasyonun belirlenmesinde MPV ve NLR' nin rolünü araştırdık. Gereç ve Yöntem: Retrospektif olarak dizayn edilmiş olan bu çalışmaya gut hastalarının dosyaları taranarak çalışmaya dahil edilme kriterlerini karşılayan toplam 106 ( 91 erkek, 15 kadın) gut hastası ve yaş-cinsiyet eşleştirmeli 148 ( 128 erkek, 20 kadın) sağlıklı kontrol grubu alındı. Hasta grubunun atak dönemi (Grup I) ve ataksız dönemi (grup II) laboratuvar verileri toplandı. Bulgular: Gut hasta grubu yaş ortalaması 59.46±12.93 yıl, sağlık-lı kontrol grubu yaş ortalaması 59±11.33 yıl idi. Her iki grup yaş ve cinsiyet açısından benzerdi. İlk atak yaşı 52±12.77 yıl, ilk iki atak arası süre 6±5.52 ay idi. Hastaların 9'unda (%8.5) tofüs, 17'sinde (%16) gut aile öyküsü vardı. MPV her üç grupta da benzerdi. CRP ve eritrosit sedimentasyon hızı, atak dönem gut hasta grubunda ataksız dönem gut hasta grubuna göre istatistiksel anlamlı yüksek saptandı. N/L oranı her üç grupta da istatistiksel olarak anlamlı farklılık gösteriyordu. Tofüs varlığına göre hastalar sınıflandırıldığında ise her iki grupta da MPV ve N/L oranının benzer olduğu görüldü. Tartışma: N/L oranı hem atak hem ataksız dönem gut hastalarında sağlıklı kontrol grubuna göre artmıştı. Bu çalışma gut hastalarının kronik inflamasyona maruz kaldı-ğını göstermektedir. Bu nedenle N / L oranı gut hastalığında inflamasyonun gösterilmesinde basit, ucuz ve kullanışlı tanısal belirteç olabilir. Anahtar KelimelerGut; Nötrofillenfositoranı; Ortalama Trombosit Hacmi Abstract Aim: Gout is a clinical syndrome with increased uric acid concentration, which is caused by inflammatory response against monosodium urate (MSU) crystals. In gout, neutrophils are involved in inflammatory response and neutrophil activation is dependent on local cytokine production. Mean platelet volume (MPV) and neutrophillymphocyte ratio (NLR) are considered as inflammatory markers in several diseases and it is reported that they may have prognostic significance. Inthe current literature, there is no study evaluating MPV and NLR in gout. In this retrospective study, we investigated the role of MPV and NLR in determining inflammation in gout disease. Material and Method: In this retrospective study, 106 patients with gout (91 men and 15 women) meeting the inclusion criteria based on patient records and 148 ageand sex-matched healthy controls (128 men and 20 women) were included. Laboratory data during...

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Neutrophil–Lymphocyte Ratio and the Platelet–Lymphocyte Ratio Predict the Limb Survival in Critical Limb Ischemia

Abstract: Admission NLR and PLR both merit further evaluation as prognostic indices in patients with CLI.

Cited by 67 publications

References 32 publications

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

The Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Markers for Prognosis in Idiopathic Sudden Sensorineural Hearing Loss

Neutrophil-to-Lymphocyte and Platelet-to- Lymphocyte Ratios in Pediatric Patients with Idiopathic Sudden Hearing Loss

Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

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