Neutrophil-Lymphocyte Ratio and Procalcitonin as Predictors of the Severity of Acute Pancreatitis

Abstract

The Neutrophil-Lymphocyte Ratio (NLR) and procalcitonin are used to indicate systemic inflammation in variousmedical disorders. Both parameters were determined in this study to predict the severity of acute pancreatitis. This studywas a cross-sectional study using a retrospective approach to patients diagnosed with acute pancreatitis by using medicalrecord data from patients at Dr. Wahidin Sudirohusoso Hospital, Makassar, from January 2014 to May 2019. This studycomprised 35 patients hospitalized with acute pancreatitis, with a similar proportion of males and females. This studydiscovered that the mean age in this study was 44.17±12.9 years. The most prevalent cause was Gallstones (77.1%), themost severe degree was mild (54.2%), and the highest outcome was survival (77.1%). The NLR (9.93±11.19, p=0.011)increased in proportion to severity. However, additional analysis based on classification of disease severity revealed thatonly mild-severe NLR was significant (p=0.005). Procalcitonin (8.13±11.25, p=0.001) increased along with the increaseddisease severity, and the subsequent analysis showed that the distribution of severity was similar. The NLR can predict theseverity of acute pancreatitis but is less effective than procalcitonin. This study required a more proportional subjectpopulation and consideration of other factors.

Faktor-Faktor yang Berhubungan dengan Length of Stay Pasien Pneumonia di Rumah Sakit Umum Haji Medan

“…Faktor infeksi pneumonia juga bertanggung jawab atas leukopenia, yakni kondisi seseorang memiliki kadar sel darah putih yang rendah seperti yang ditunjukkan pada penelitian sebelumnya di mana leukopenia parah (≤3000 sel/µL) merupakan faktor bahaya bagi peningkatan klinis hingga kematian bagi pasien pneumonia CAP (Khanafer et al, 2013) (Afiah et al, 2023;WAHYUNI, 2023). Disisi lain, berbeda dengan hasil kajian teori yang menunjukkan bahwa reaksi RNL merupakan biomarker dalam mencerminkan keseimbangan antara dua aspek proses imun yakni peradangan akut (neutrofil) dan imunitas adaptif (limfosit) (Song et al, 2021).…”