Neutrophil-lymphocyte ratio and nodal pathologic complete response in node positive breast cancer patients undergoing neoadjuvant chemotherapy

Gasparri, Maria Luisa; Micco, Rosa Di; Bassi, V.; Sevas, Vasileios; Meani, Francesco; Papadia, Andrea; Gentilini, Oreste

doi:10.1016/s0960-9776(21)00208-3

Cited by 1 publication

(3 citation statements)

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“…[110] And, the results of a recent multicenter study involving 1274 patients treated with NAC also confirmed that low PIV independently predicts an increased likelihood of lymph node pCR. [80] In operable breast cancer patients, PIV showed the same results for predicting prognosis. [111] Another retrospective study including 57 patients with HER2-positive breast cancer showed that high PIV was associated with poorer PFS and OS in patients treated with first-line taxane-trastuzumab-pertuzumab.…”

Section: Peripheral Blood Inflammatory Indexes In Breast Cancermentioning

confidence: 99%

“…In addition, NLR has been found to predict axillary nodal pathologic complete response after neoadjuvant therapy for breast cancer. [79,80] Philip et al [81] found a strong correlation between NLR and pathological lymph node status in patients with TNBC (75% cases node-positive in the high NLR group vs 36% in the low NLR group). Additionally, NLR was found to be associated with clinical stage, but there was no significant correlation between it and OS.…”

Section: Nlrmentioning

confidence: 99%

“…In addition, NLR has been found to predict axillary nodal pathologic complete response after neoadjuvant therapy for breast cancer. [79,80]…”

Section: Peripheral Blood Inflammatory Indexes In Breast Cancermentioning

confidence: 99%

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Peripheral blood inflammatory indexes in breast cancer: A review

Xie,

Guo,

Zhu

et al. 2023

Medicine

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Immune and inflammatory responses play an important role in tumorigenesis and metastasis. Inflammation is an important component of the tumor microenvironment, and the changes in inflammatory cells may affect the occurrence and development of tumors. Complete blood count at the time of diagnosis and treatment can reflect the inflammatory status within the tumor. Studies have shown that the number of certain inflammatory cells in peripheral blood and their ratios are important prognostic factors for many malignancies, including neutrophil, lymphocyte, monocyte, and platelet counts, as well as neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, systemic immune-inflammation index, systemic inflammation response index and pan-immune-inflammation-value. The value of peripheral blood inflammation indexes in predicting the efficacy and prognosis of breast cancer neoadjuvant therapy is worth recognizing. This review details the application of peripheral blood inflammation indexes in the evaluation of efficacy and prediction of prognosis in neoadjuvant therapy for breast cancer, aiming to provide a more comprehensive reference for the comprehensive diagnosis and treatment of breast cancer.

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Section: Peripheral Blood Inflammatory Indexes In Breast Cancermentioning

confidence: 99%