Neutrophil/lymphocyte ratio and its association with survival after complete resection in non–small cell lung cancer

Sarraf, Khaled M; Belcher, Elizabeth; Raevsky, Evgeny; Nicholson, Andrew G.; Goldstraw, Peter; Lim, Eric

doi:10.1016/j.jtcvs.2008.05.046

Cited by 504 publications

(452 citation statements)

References 12 publications

(12 reference statements)

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“…Patients with colorectal, ovary and lung cancer were preoperatively stratified according to NLR as those with NLR>5 and those with NLR<5. It was reported that cancer-related mortality was significantly higher in patients with NLR>5 (Sarraf et al, 2009;Chua et al, 2011). In a study on patients with colorectal cancer, Kishi et al reported that mortality was higher in patients with high NLR who had liver metastasis and received neo-adjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Prognosis and Neutrophil: Lymphocyte and Platelet:Lymphocyte Ratios in Patients with Malignant Pleural Mesotheliomas

Cihan¹,

Öztürk²,

Mutlu³

2014

Asian Pacific Journal of Cancer Prevention

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Background: It has been demonstrated that neutrophil:lymphocyte (NLR) and platelet:lymphocyte (PLR) ratios are associated with prognosis in cancer patients. The aim of this study was to investigate whether pretreatment white blood cell (WBC), neutrophil, lymphocyte, monocyte, platelet, basophil and eosinophil counts, LDH level, NLR and PLR are associated with prognosis in patients with malignant pleural mesothelioma (MPM). Materials and Methods: We retrospectively reviewed files of 50 patients who were managed with a diagnosis of MPM between 2005 and 2010. Demographic and clinical characteristics, treatments, response to treatment and prognostic factors were evaluated, along with relationships between pretreatment blood parameters and prognosis. Results: Overall, 38 men and 12 women were included to the study. Mean age was 61.5±9.4 years (range: 39-83 years). There was advanced disease in 86% (n=43) and the histological type was epithelial mesothelioma in the majority (82%). Of the cases, 17 (34%) received radiotherapy, while 42 cases underwent first-and second-line chemotherapy, with cisplatin plus pemetrexed as the most commonly used regimen. In the assessment after therapy, it was found that there was complete response in 4 cases (8%), partial response in 10 cases (20%), stable disease in 17 cases (34%) and progression in 19 cases (38%). Median follow-up was 10 months (range: 10 day-30 months). Median overall survival was found to be 20.7 months while median progression-free survival as 10 months. In univariate and multivariate analyses, it was found that factors significantly affecting overall survival included stage (p=0.030), response to treatment (p=0.026) and monocyte count (p=0.004), while factors affecting disease-free survival included NLR (p=0.018), response to treatment (p=0.001), and PLR score (p=0.003). Conclusions: Overall and disease-free survival was found to be better in cases with a WBC count<8.000, platelet count<300,000, and low NLR and PLR scores in malignant pleural mesothelioma.

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Section: Discussionmentioning

confidence: 99%

Relationship Between Prognosis and Neutrophil: Lymphocyte and Platelet:Lymphocyte Ratios in Patients with Malignant Pleural Mesotheliomas

Cihan¹,

Öztürk²,

Mutlu³

2014

Asian Pacific Journal of Cancer Prevention

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“…The NLR dropped after surgery, but upon relapse it rose again [382]. Similarly, Sarraf et al [154] observed higher NLR in more advanced non-small cell lung cancer patients and Fossatti et al [207] observed a marked and significant correlation between tumor grade of glioma patients and the extent of neutrophil infiltration as determined by the number of CD15 + MPO + cells [207]. In low grade tumors 40-50 % show neutrophil infiltration, while in glioblastoma multiforme over 85 % of the samples show neutrophil infiltration [207].…”

Section: Prognostic Values Of Neutrophils and Other Myeloid Subtypes mentioning

confidence: 99%

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Sionov

Fridlender

Granot

2014

Cancer Microenvironment

336

261

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Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.

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“…Several recent studies have revealed a correlation between clinical outcomes with common solid tumors (colorectal cancer, lung cancer, breast cancer and pancreatic cancer, etc) and systemic inflammatory response, including plasma C-reactive protein (CRP), hypoalbuminemia, and a selective combination of C-reactive protein and albumin termed as Glasgow Prognostic Score (GPS) (Leitch et al, 2007;Hwang et al, 2011;Jiang et al, 2012;Fox et al, 2013;McMillan, 2013). There were also many studies reporting that haematological markers of systemic inflammatory response such as white blood cell count or its components (neutrophil, lymphocyte, neutrophil-lymphocyte ratio (NLR)), platelet, and platelet-lymphocyte ratio (PLR) are also prognostic indicators for cancer clinical outcomes (Yamanaka et al, 2007;Cho et al, 2009;Kishi et al, 2009;Sarraf et al, 2009;Kwon et al, 2012;Dalpiaz et al, 2013;Fox et al, 2013). In addition, other inflammatory factor combinations such as Prognostic Index (PI) and Prognostic Nutritional Index (PNI) have also been linked with prognosis of malignancies (Kasymjanova et al, 2010;Nozoe et al, 2010;Kanda et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

Li¹,

Lü²,

Yang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Purpose: To explore the value of systemic inflammatory markers as independent prognostic factors and the extent these markers improve prognostic classification for patients with inoperable advanced or metastatic gastric cancer (GC) receiving palliative chemotherapy. Methods: We studied the prognostic value of systemic inflammatory factors such as circulating white blood cell count and its components as well as that combined to form inflammation-based prognostic scores (Glasgow Prognostic Score (GPS), Neutrophil-Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI) and Prognostic Nutritional Index (PNI)) in 384 patients with inoperable advanced or metastatic gastric cancer (GC) receiving first-line chemotherapy. Univariate and multivariate analyses were performed to examine the impact of inflammatory markers on overall survival (OS). Results: Univariate analysis revealed that an elevated white blood cell, neutrophil and/or platelet count, a decreased lymphocyte count, a low serum albumin concentration, and high CRP concentration, as well as elevated NLR/PLR , GPS, PI, PNI were significant predictors of shorter OS. Multivariate analysis demonstrated that only elevated neutrophil count (HR 3.696, p=0.003) and higher GPS (HR 1.621, p=0.01) were independent predictors of poor OS. Conclusion: This study demonstrated elevated pretreatment neutrophil count and high GPS to be independent predictors of shorter OS in inoperable advanced or metastatic GC patients treated with first-line chemotherapy. Upon validation of these data in independent studies, stratification of patients using these markers in future clinical trials is recommended.

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Neutrophil/lymphocyte ratio and its association with survival after complete resection in non–small cell lung cancer

Abstract: Increasing preoperative neutrophil/lymphocyte ratios are associated with higher stage but remain an independent predictor of survival after complete resection for primary lung cancer and are a potential biomarker to stratify high risk of death in patients with stage I disease.

Cited by 504 publications

References 12 publications

Relationship Between Prognosis and Neutrophil: Lymphocyte and Platelet:Lymphocyte Ratios in Patients with Malignant Pleural Mesotheliomas

Relationship Between Prognosis and Neutrophil: Lymphocyte and Platelet:Lymphocyte Ratios in Patients with Malignant Pleural Mesotheliomas

The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment

Neutrophil Count and the Inflammation-based Glasgow Prognostic Score Predict Survival in Patients with Advanced Gastric Cancer Receiving First-line Chemotherapy

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