Neutrophil–lymphocyte Ratio and C-Reactive Protein Levels are not Associated with Strength, Muscle Mass, and Functional Capacity in Kidney Transplant Patients

Santos, Heitor O.; Limirio, Larissa S.; Reis, Aline S. dos; Nehme, Rafaela; Floriano, João Pedro; Gomes, Gederson K; Pimentel, Gustavo D.; Oliveira, Erick P. de

doi:10.1007/s10753-022-01705-1

Cited by 1 publication

(4 citation statements)

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“…Notably, the risk of sarcopenia exhibited a significant increase with rising NLR in overweight patients undergoing MHD, in contrast to non-overweight MHD patients. It can be assumed that in participants who had relatively low-grade inflammation, there was no apparent correlation between NLR and the risk of sarcopenia, aligning with the results reported by Ho et al 20 . Conversely, in individuals with higher-grade inflammation, an elevated NLR is indicative of an increased risk of sarcopenia.…”

Section: Discussionsupporting

confidence: 88%

“…Conversely, in non-overweight participants, the relationship between NLR and sarcopenia risk was not statistically significant. This pattern parallels findings in kidney transplantation patients (KTPs), where NLR was not significantly correlated with muscle mass, strength, or functional capacity 20 . Tang et al also reported a lack of association between NLR and appendicular skeletal muscle or handgrip strength 17 in Chinese community-dwelling older people.…”

Section: Discussionsupporting

confidence: 83%

“…This study has several strengths. Firstly, despite extensive investigations into the association between NLR and the risk of sarcopenia across various populations, the results have remained controversial 13 , 20 . Notably, the role of overweight in both inflammation and sarcopenia development has been underscored, yet few studies have explored the interaction between overweight status and NLR concerning sarcopenia.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have assessed the correlation between NLR and the components of sarcopenia in different populations, including community dwelling older adults 17 and patients with cancer or undergoing hemodialysis 13 , 18 . However, while some studies have shown significant associations between the NLR and sarcopenia risk 13 , 18 , 19 , others have not 17 , 20 , which indicates the association between the NLR and sarcopenia risk remains uncertain.…”

Section: Introductionmentioning

confidence: 98%

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Neutrophil-to-lymphocyte ratio is associated with sarcopenia risk in overweight maintenance hemodialysis patients

Nie,

Liu,

Zeng

et al. 2024

Sci Rep

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Neutrophil-to-lymphocyte ratio (NLR), a novel inflammatory marker, is strongly associated with the risk of sarcopenia. Notably, being overweight has been found to accelerate the loss of skeletal muscle mass and function in chronic kidney disease (CKD) patients. However, the effect of overweight status on the relationship between NLR and sarcopenia risk has been poorly studied. We conducted a cross-sectional study at a hemodialysis center in Chengdu, China, from September to December 2022. The prevalence of sarcopenia was determined according to the Asian Working Group for Sarcopenia (AWGS). Participants were stratified based on body mass index (BMI) categories for the Asian population (non-overweight < 23 kg/m2 and overweight ≥ 23 kg/m2). 272 participants aged 18–85 years were included, with 144 being male. The overall prevalence of sarcopenia was 32.72% (89/272). After adjusting for covariates, NLR was significantly associated with sarcopenia risk in overweight participants (OR 1.60, 95% CI 1.15–2.24, p = 0.006), whereas it was not significant in the non-overweight group (OR 0.88, 95% CI 0.70–1.10, p = 0.254). Moreover, subgroup analysis showed a significant interactive association between NLR and overweight status with respect to sarcopenia. These findings emphasize the potential significance of regular screening of NLR for the early detection of sarcopenia in overweight patients undergoing maintenance hemodialysis.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 83%