Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice

Zhang, Yingying; Sheng, Ziyang; Chen, Qiaozhu; Zhou, Anni; Cao, Jin; Xue, Fei; Ye, Yanzhen; Wu, Na; Gao, Na; Fan, Dongying; Liu, Libo; Li, Yuetong; Wang, Peigang; Li, Liang; Zhou, Dujin; Zhang, Fuchun; Li, Fang; An, Jing

doi:10.1016/j.ebiom.2023.104739

Cited by 3 publications

(3 citation statements)

References 76 publications

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“…Many etiological factors have been identified in the pathogenesis of FGR, encompassing various pathways (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Among the most significant are inflammation, inadequate angiogenesis, and oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…It is associated with long-term complications such as metabolic syndrome, cardiovascular disease, and diabetes, as well as short-term complications like low birth weight, prematurity, neonatal exit, and a high number of neonates in the intensive care unit (1)(2)(3)(4). The pathogenesis is multifactorial, involving genetic factors, maternal inflammation, immune system abnormalities, infections, oxidative stress, defects in spiral artery remodeling, and endocrine causes (4)(5)(6)(7)(8)(9)(10)(11).…”

mentioning

confidence: 99%

“…It is well-known that inflammation plays a major role in tissue homeostasis (12). To prevent tissue rejection at the beginning of pregnancy, there is a physiological rearrangement of the innate immune system and cytokine network (6,7,11,12). Changes occur in the inflammatory and infectious balance, especially in the activity of T cells, with the goal of maintaining the fetomaternal relationship in balance.…”

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confidence: 99%

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The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

Ağaoğlu

2023

Acad J Health

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Objectives: Our aim was to investigate the significance of parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammatory index (SII), and systemic inflammatory response index (SIRI) in late fetal growth restriction (FGR) cases.Methods: After applying the exclusion criteria, 70 late FGR cases and 70 healthy pregnant cases matched by maternal age and week of gestation were included in the study. In addition to demographic characteristics, neonatal outcomes, and peripheral blood parameters, we examined whether there were differences between groups in NLR, PLR, MLR, SII, and SIRI scores. We also investigated the association between systemic inflammatory markers and neonatal intensive care unit (NICU) admission. P-values < 0.05 were interpreted as statistically significant. Results:The FGR group had higher leukocyte, neutrophil, NLR, and SII values than the control group (p=0.019; p=0.007; p=0.011; p=0.005, respectively). For the diagnosis of FGR, an optimal cut-off value of ≥4.7946 was found for NLR (with 54.7% sensitivity and 85.7% specificity) and a value of ≥918.15 for SII (with 67.1% sensitivity and 60% specificity). PLR and SII were higher in the FGR group with NICU admission than in the FGR group without NICU admission (p=0.024; p=0.012, respectively). Conclusion:SII, in addition to other clinical data, may contribute to both the diagnosis of FGR and the prediction of NICU admission in FGR cases. This finding is supported by randomized controlled trials with large series of prospective subgroup analyses.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

Ağaoğlu

2023

Acad J Health

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Transamniotic Stem Cell Therapy Modulates Uterine Natural Killer Cell Activity in the Hypoxia Model of Intrauterine Growth Restriction

Whitlock,

Moskowitzova,

Kycia

et al. 2024

Stem Cells and Development

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The gut microbiota contributes to the infection of bovine viral diarrhea virus in mice

Zhang,

Huang,

et al. 2024

J Virol

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Bovine viral diarrhea virus (BVDV) is prevalent worldwide and causes significant economic losses. Gut microbiota is a large microbial community and has a variety of biological functions. However, whether there is a correlation between gut microbiota and BVDV infection and what kind of relation between them have not been reported. Here, we found that gut microbiota composition changed in normal mice after infecting with BVDV, but mainly the low abundance microbe was affected. Interestingly, BVDV infection significantly reduced the diversity of gut microbiota and changed its composition in gut microbiota-dysbiosis mice. Furthermore, compared with normal mice of BVDV infection, there were more viral loads in the duodenum, jejunum, spleen, and liver of the gut microbiota-dysbiosis mice. However, feces microbiota transplantation (FMT) reversed these effects. The data above indicated that the dysbiosis of gut microbiota was a key factor in the high infection rate of BVDV. It is found that the IFN-I signal was involved by investigating the underlying mechanisms. The inhibition of the proliferation and increase in the apoptosis of peripheral blood lymphocytes (PBL) were also observed. However, FMT treatment reversed these changes by regulating PI3K/Akt, ERK, and Caspase-9/Caspase-3 pathways. Furthermore, the involvement of butyrate in the pathogenesis of BVDV was also further confirmed. Our results showed for the first time that gut microbiota acts as a key endogenous defense mechanism against BVDV infection; moreover, targeting regulation of gut microbiota structure and abundance may serve as a new strategy to prevent and control the disease. IMPORTANCE Whether the high infection rate of BVDV is related to gut microbiota has not been reported. In addition, most studies on BVDV focus on in vitro experiments, which limits the study of its prevention and control strategy and its pathogenic mechanism. In this study, we successfully confirmed the causal relationship between gut microbiota and BVDV infection as well as the potential molecular mechanism based on a mouse model of BVDV infection and a mouse model of gut microbiota dysbiosis. Meanwhile, a mouse model which is more susceptible to BVDV provided in this study lays an important foundation for further research on prevention and control strategy of BVDV and its pathogenesis. In addition, the antiviral effect of butyrate, the metabolites of butyrate-producing bacteria, has been further revealed. Overall, our findings provide a promising prevention and control strategy to treat this infectious disease which is distributed worldwide.

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Neutrophil infiltration leads to fetal growth restriction by impairing the placental vasculature in DENV-infected pregnant mice

Cited by 3 publications

References 76 publications

The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

The significance of Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) in fetuses with fetal growth restriction

Transamniotic Stem Cell Therapy Modulates Uterine Natural Killer Cell Activity in the Hypoxia Model of Intrauterine Growth Restriction

The gut microbiota contributes to the infection of bovine viral diarrhea virus in mice

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