Neutrophil Gelatinase-Associated Lipocalin (NGAL): an early marker for diabetic nephropathy

Mohamad, Fathimah; Kasim, Noor Alicezah Mohd; Thevarajah, M.

doi:10.1007/s13410-011-0061-z

Cited by 7 publications

(8 citation statements)

References 19 publications

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“…Results obtained above were in agreement with previous studies which reported similar tendency for NGAL[ 33 ] and other biomarkers of tubular injury such as NAG, MCP, uLFABP, and KIM-1 whose level corresponds with degree of proteinuria[ 24 34 35 36 37 ] but contradicted by Kim et al ., where there were no significant differences in NGAL value between normoalbuminuria and microalbuminuria groups. [ 38 ]…”

Section: Discussionsupporting

confidence: 92%

“…In our study, sNGAL, uNGAL, and uNGAL/uCr show strong positive correlation with one another and that with albuminuria and duration of DM but negative correlation with eGFR which is supported by other study also. [ 33 37 40 43 ] However, in multivariate binary logistic regression, only UACR and uNGAL/uCr were predictors of sNGAL whereas UACR and LDL-C were predictors of uNGAL/uCr. A strong correlation between NGAL and albuminuria suggests glomerular and tubular injury may occur as parallel processes.…”

Section: Discussionmentioning

confidence: 98%

“…concluded that NGAL value does not correlate with glycemic control (HbA1c) which is supported by our study but contradicted to the study by Lacquaniti et al . [ 24 33 37 39 41 ] Nauta et al . concluded that it is not NGAL but uLFABP that predicts decline in renal function (eGFR) in diabetic individuals, whereas Nielsen et al .…”

Section: Discussionmentioning

confidence: 99%

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Neutrophil gelatinase-associated lipocalin: As a predictor of early diabetic nephropathy in Type 2 diabetes mellitus

et al. 2018

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This study was carried out to look for diagnostic and prognostic role of neutrophil gelatinase-associated lipocalin (NGAL) in early diabetic nephropathy (DN) in type 2 diabetes individuals. NGAL was measured in both urinary and serum sample of 144 type 2 diabetes individuals stratified into three categories based on urinary albumin-creatinine ratio and 54 control populations with estimated glomerular filtration rate >60 mL/min/1.73 m2 and serum creatinine <1.2 mg/dl. The serum NGAL (sNGAL), urine NGAL (uNGAL), and uNGAL/urine creatinine were significantly higher in diabetic individuals than in the control populations with significant difference in between the groups (P < 0.05). Difference of above values between control value and normoalbuminuria was also statistically significant (P < 0.05). Again, sNGAL and uNGAL correlate positively with albuminuria (P < 0.05). Tubular injury may precede glomerular injury in diabetic individuals, and NGAL can be used as a biomarker to diagnose DN even earlier to incipient nephropathy. Both sNGAL and uNGAL can predict albuminuria and be used as a noninvasive tool for diagnosis, staging, and progression of DN.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

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Neutrophil gelatinase-associated lipocalin: As a predictor of early diabetic nephropathy in Type 2 diabetes mellitus

et al. 2018

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“…We also demonstrated a relationship of plasma and urinary NGAL parameters with patient's age and sex. However, in some studies there were no effects of such demographic parameters as age, sex, and race on uNGAL [16].…”

Section: Discussionmentioning

confidence: 95%

Is Neutrophil Gelatinase–Associated Lipocalin an Optimal Marker of Renal Function and Injury in Liver Transplant Recipients?

Hryniewiecka

Gala

Krawczyk

et al. 2014

Transplantation Proceedings

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“…Normoalbuminuric diabetes patients had significantly greater mean urinary NGAL levels than the controls which suggests that tubular injury may occur before the onset of glomerular injury in patients with diabetes. This suggests that tubular dysfunction is due to hemodynamic and metabolic stress which is secondary to chronic hyperglycemia in patients with diabetes mellitus [34,35].…”

Section: T a B L E 5 Receiver Operating Characteristics Curve Analysis Of Urinary Ngal Microalbuminuria And Acrmentioning

confidence: 99%

Urine neutrophil gelatinase-associated lipocalin as an early biochemical marker of microalbuminuria in predicting early kidney damage in patients with type 2 diabetes mellitus

Padmini¹,

Ashok²

2021

Ukr.Biochem.J.

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diabetic nephropathy is one of the microvascular complications of diabetes mellitus. The study was done to evaluate the diagnostic value of neutrophil gelatinase-associated lipocalin (NGaL) urine level as a biomarker for the early detection of nephropathy in type 2 diabetic patients. This study was performed on 150 patients with type 2 diabetes mellitus classified into three equal groups according to their urine albumin/ creatinine ratio (ACR), including patients with normoalbuminuria (ACR < 30 mg/g creatinine), microalbuminuria (ACR = 30-300 mg/g creatinine) and macroalbuminuria (ACR > 300 mg/g creatinine). Fifty apparently healthy subjects were selected as a control group. Urine NGaL was estimated by a particle-enhanced turbidimetric immunoassay using hitachi 917 analyzer. The serum level of glucose and creatinine was also estimated. The results showed that NGAL urine level was significantly elevated in diabetes patient groups with microalbuminuria and macroalbuminuria when compared to the control group and diabetes patient group with normoalbuminuria. The levels of urine NGaL correlated positively with microalbuminuria in patients with diabetes. Receiver operating characteristic curves revealed that urine NGaL had a higher diagnostic value for diabetic nephropathy early detection compared to aCR and microalbuminuria in patients with diabetes mellitus.K e y w o r d s: gelatinase-associated lipocalin, diabetic nephropathy, albumin/creatinine ratio microalbuminuria .

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Neutrophil Gelatinase-Associated Lipocalin (NGAL): an early marker for diabetic nephropathy

Cited by 7 publications

References 19 publications

Neutrophil gelatinase-associated lipocalin: As a predictor of early diabetic nephropathy in Type 2 diabetes mellitus

Neutrophil gelatinase-associated lipocalin: As a predictor of early diabetic nephropathy in Type 2 diabetes mellitus

Is Neutrophil Gelatinase–Associated Lipocalin an Optimal Marker of Renal Function and Injury in Liver Transplant Recipients?

Urine neutrophil gelatinase-associated lipocalin as an early biochemical marker of microalbuminuria in predicting early kidney damage in patients with type 2 diabetes mellitus

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