Neutrophil gelatinase-associated lipocalin levels during the first 48 hours of intensive care may indicate upcoming acute kidney injury

Kamış, Fatih; Yeğenağa, Itır; Musul, Mert; Baydemır, Canan; Bek, Sibel Gökçay; Kalender, Betül; Baykara, Nur

doi:10.1016/j.jcrc.2016.04.012

Cited by 10 publications

(8 citation statements)

References 23 publications

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“…We previously studied NGAL in serum and urine and determined that this biomarker effectively predicts the eventual development of AKI in patients. 14 In this study, we evaluated CysC on the second day after ICU admission to determine whether it could predict the development of AKI as well as NGAL after seven days in the ICU.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil gelatinase-associated lipocalin is a better biomarker than cystatin C for the prediction of imminent acute kidney injury in critically ill patients

et al. 2017

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Aims The prevention of acute kidney injury can be lifesaving for the intensive care unit patients. However, conventional methods are not sufficient for the prediction of the risk of future acute kidney injury. In this study, the promising biomarker, neutrophil gelatinase-associated lipocalin, was compared with cystatin C as an indicator for the risk of future acute kidney injury. Methods One hundred and eighty-three adult patients without chronic kidney disease or renal replacement therapy were included in this study. The plasma and urine concentrations of neutrophil gelatinase-associated lipocalin and cystatin C were assessed on the second day after intensive care unit admission and were followed for seven days to monitor the development of acute kidney injury. Acute kidney injury diagnosis was based on the risk, injury, failure, loss, end-stage renal failure criteria. Results Thirty-four per cent of the patients had acute kidney injury; 17 patients who did not fulfil criteria at the beginning, developed acute kidney injury from days 3 to 7 after admission. The mean serum creatinine on admission did not significantly differ between this and control groups (0.72 ± 0.20 and 0.83 ± 0.21; P = 0.060); however, the serum and urinary neutrophil gelatinase-associated lipocalin concentrations on the second day were significantly different (median: 75.69 [54.18-91.18] and 123.68 [90.89-166.31], P = 0.001; and median: 17.60 [8.56-34.04] and 61.37 [24.59-96.63], P = 0.001). Notably, the 48-h serum cystatin C concentration did not differ. Conclusion Neutrophil gelatinase-associated lipocalin concentrations in the urine and serum on the second day of intensive care unit admission could be used to predict the development of acute kidney injury in the following three to seven days in the intensive care unit; however, the cystatin C concentration did not have predictive value.

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Section: Introductionmentioning

confidence: 99%

Neutrophil gelatinase-associated lipocalin is a better biomarker than cystatin C for the prediction of imminent acute kidney injury in critically ill patients

et al. 2017

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“…The sNGAL , uNGAL and sCysC levels were determined at 48 hours of admission and surprisingly we found that sNGAL , uNGAL(AUC-ROC: 0.77, p = 0.005; 0.78, p = 0.002) but not CysC (0.54, p = 0.657)were useful for predicting of the development of AKI following 3-7 days in the ICU [6].…”

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confidence: 66%

Cystatin C is not Useful to Predict Approaching Acute Kidney Injury in Unstable Critical Care Patients

2016

Internal Med Res Open J

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“…Even with careful protocol driven fluid administration, we demonstrated increased urine output with A2AR agonist treatment (Figure 6B). Furthermore, several studies have correlated higher urine NGAL concentration with increased incidence of renal injury in ICU and cardiac surgery patients 42,43 . Our data confirm significantly lower urine NGAL in the A2AR agonist treatment groups (Figure 7A).…”

Section: Discussionmentioning

confidence: 99%

Adenosine 2A Receptor Activation Attenuates Ischemia Reperfusion Injury During Extracorporeal Cardiopulmonary Resuscitation

et al. 2019

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Neutrophil gelatinase-associated lipocalin levels during the first 48 hours of intensive care may indicate upcoming acute kidney injury

Cited by 10 publications

References 23 publications

Neutrophil gelatinase-associated lipocalin is a better biomarker than cystatin C for the prediction of imminent acute kidney injury in critically ill patients

Neutrophil gelatinase-associated lipocalin is a better biomarker than cystatin C for the prediction of imminent acute kidney injury in critically ill patients

Cystatin C is not Useful to Predict Approaching Acute Kidney Injury in Unstable Critical Care Patients

Adenosine 2A Receptor Activation Attenuates Ischemia Reperfusion Injury During Extracorporeal Cardiopulmonary Resuscitation

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