Neutrophil gelatinase-associated lipocalin as diagnostic and prognostic tool for cardiovascular disease and heart failure

Iqbal, Navaid; Choudhary, Rajiv; Chan, Jeffrey; Wentworth, Bailey; Higginbotham, Erin; Maisel, Alan S.

doi:10.1517/17530059.2013.763795

Cited by 12 publications

(13 citation statements)

References 84 publications

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“…LCN2 has been implicated in several critical biological processes, including innate immunity, cell proliferation, and apoptosis. Serum and urine LCN2 are considered as biomarkers for early diagnosis of acute kidney injury (Haase-Fielitz et al 2014; Makris and Kafkas 2012) and cardiovascular disease (Iqbal et al 2013). As Lcn2 was significantly induced by silica, bleomycin, or paraquat from the microarray analysis (Fig.…”

Section: Resultsmentioning

confidence: 99%

Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents

Dong

Porter

et al. 2015

Arch Toxicol

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Pulmonary fibrosis results from the excessive deposition of collagen fibers and scarring in the lungs with or without an identifiable cause. The mechanism(s) underlying lung fibrosis development is poorly understood, and effective treatment is lacking. Here we compared mouse lung fibrosis induced by pulmonary exposure to prototypical particulate (crystalline silica) or soluble chemical (bleomycin or paraquat) fibrogenic agents to identify the underlying mechanisms. Young male C57BL/6J mice were given silica (2 mg), bleomycin (0.07 mg), or paraquat (0.02 mg) by pharyngeal aspiration. All treatments induced significant inflammatory infiltration and collagen deposition, manifesting fibrotic foci in silica-exposed lungs or diffuse fibrosis in bleomycin or paraquat-exposed lungs on day 7 post-exposure, at which time the lesions reached their peaks and represented a junction of transition from an acute response to chronic fibrosis. Lung genomewide gene expression was analyzed, and differential gene expression was confirmed by quantitative RT-PCR, immunohistochemistry, and immunoblotting for representative genes to demonstrate their induced expression and localization in fibrotic lungs. Canonical signaling pathways, gene ontology, and upstream transcription networks modified by each agent were identified. In particular, these inducers elicited marked proliferative responses; at the same time, silica preferentially activated innate immune functions and the defense against foreign bodies, whereas bleomycin and paraquat boosted responses related to cell adhesion, platelet activation, extracellular matrix remodeling, and wound healing. This study identified, for the first time, the shared and unique genes, signaling pathways, and biological functions regulated by particulate and soluble chemical fibrogenic agents during lung fibrosis, providing insights into the mechanisms underlying human lung fibrotic diseases.

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Section: Resultsmentioning

confidence: 99%

Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents

Dong

Porter

et al. 2015

Arch Toxicol

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“…Clinical studies have confirmed the diagnostic and prognostic value of NGAL in various settings, 6 , 8 but few of them used the RT-POCT NGAL in critically ill patients in the ED for evaluating its efficacy. In this study, we reported our experience of RT-POCT NGAL for detecting AKI in critically ill patients of an urban university tertiary hospital ED.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum neutrophil gelatinase-associated lipocalin in predicting acute kidney injury in critically ill patients

et al. 2017

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ObjectiveThis investigation evaluated the real-time point-of-care testing (RT-POCT) of neutrophil gelatinase-associated lipocalin (NGAL) for detecting acute kidney injury (AKI) and prognosis of critically ill patients.MethodsA total of 249 critically ill patients in the emergency department (ED), who were diagnosed with acute decompensated heart failure, sepsis or diabetic ketoacidosis were enrolled in this study. All enrolled patients were followed up for 28 days or to death and the mortalities were recorded. Serum creatinine (sCr) and NGAL were measured.Results40.6% enrolled patients deteriorated to AKI during the observation period. The NGAL level was significantly higher in the AKI versus non-AKI group. The NGAL levels in the non-survivors group at 7-day and 28-day were significantly higher than in the survivors group. NGAL was detected as an independent risk factor of AKI, and 7-day and 28-day morality. The receiver operating characteristic curve of NGAL was calculated for diagnosing AKI; the area under the curve (AUC) was significantly higher than that of 1-day eGFR.ConclusionsNGAL is an independent predictor of AKI, and 7-day and 28-day mortality in critically ill ED patients, and can be an early alert for AKI and useful for determining prognosis.

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“…14 Circulating NGAL is under intense investigation as a diagnostic and prognostic tool for cardiovascular diseases. 15 High plasma NGAL predicts all cause mortality and major adverse cardiovascular events in ST segment elevation myocardial infarction, 16 as well as in the general population. 17,18 In patients with coronary artery disease, levels of circulating NGAL reflect the degree of inflammatory process.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is Associated with Symptomatic Carotid Atherosclerosis and Drives Pro-inflammatory State In Vitro

Eilenberg

Stojković

Piechota-Polańczyk

et al. 2016

European Journal of Vascular and Endovascular Surgery

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Neutrophil gelatinase-associated lipocalin as diagnostic and prognostic tool for cardiovascular disease and heart failure

Cited by 12 publications

References 84 publications

Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents

Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents

Evaluation of serum neutrophil gelatinase-associated lipocalin in predicting acute kidney injury in critically ill patients

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is Associated with Symptomatic Carotid Atherosclerosis and Drives Pro-inflammatory State In Vitro

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