Neutrophil function in young and old caregivers

Vitlić, Ana; Lord, Janet M.; Arlt, Wiebke; Bartlett, David B.; Rossi, Alessandra; Arora-Duggal, Niharika; Welham, Alice; Heald, Mary; Oliver, Chris; Phillips, Anna C.

doi:10.1111/bjhp.12156

Cited by 9 publications

(7 citation statements)

References 64 publications

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“…These deviations are most evident in older caregivers, but in younger individuals, this condition also leads to increased immune aging as indicated by advanced T cell differentiation. Although steady-state neutrophil anti-bacterial function appears not significantly different between caregivers and controls, those with higher psychological morbidity have poorer neutrophil phagocytosis capacity, suggesting decreased function of the cells under challenging conditions [53].…”

Section: Immune Consequences Of Stress Induced By Caregiving To Child...mentioning

confidence: 87%

Biological Consequences of Psychological Distress in Caregivers of Children with Autism Spectrum Disorder and its Potential Relevance to Other Chronic Diseases Including Cancer

Neijs¹,

Leenen

Hays

et al. 2020

Curr Epidemiol Rep

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Purpose of Review Caregivers of children with a chronic illness are a neglected group in medical research and patient care, and are frequently confronted with chronic psychological distress. The biological consequences of this chronic distress are unclear but highly relevant, as these caregivers have a lifelong task in caring for their child. In this review, the authors specifically describe caregiver distress related to autism spectrum disorder (ASD), but the review may be relevant to other chronic diseases, including cancer. Recent Findings Epidemiological evidence illustrates the increased mortality risk in caregivers of children with ASD although some individual factors appear to diminish these risks. Biological studies demonstrate that caregiver distress can lead to dysregulation of the hypothalamic-pituitary-adrenal-axis, a pro-inflammatory state of the immune and central nervous system, and gut microbiome imbalance. Summary Caregivers of children with a chronic illness like ASD deserve more health-related attention with respect to their psychological and physical well-being. Such attention would benefit individual caregivers, as well as their children, as both are highly interconnected. Structural psychological and physical screening of caregivers can be considered.

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Section: Immune Consequences Of Stress Induced By Caregiving To Child...mentioning

confidence: 87%

Biological Consequences of Psychological Distress in Caregivers of Children with Autism Spectrum Disorder and its Potential Relevance to Other Chronic Diseases Including Cancer

Neijs¹,

Leenen

Hays

et al. 2020

Curr Epidemiol Rep

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“…44 Furthermore, the reactive oxygen species produced by neutrophils has been reported to be reduced in the elderly. 45,46 The degranulation of neutrophils, associated with intracellular killing activity of neutrophils, was also impaired in the elderly. 47 However, due to the selection bias of age with 39 to 72 years in the UK Biobank, the age-dependent pattern in the correlation of neutrophil on ALS may need further exploration.…”

Section: Discussionmentioning

confidence: 99%

Neutrophils Are Associated with Higher Risk of Incident Amyotrophic Lateral Sclerosis in a BMI‐ and Age‐Dependent Manner

Cao

Tian

et al. 2023

Annals of Neurology

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ObjectivePeripheral immune markers have been associated with the progression and prognosis of amyotrophic lateral sclerosis (ALS). However, whether dysregulation of peripheral immunity is a risk factor for ALS or a consequence of motor neuron degeneration has not yet been clarified. We aimed to identify longitudinal associations between prediagnostic peripheral immunity and the risk of incident ALS.MethodsA total of 345,000 individuals from the UK Biobank between 2006 and 2010 were included at the baseline. The counts of peripheral immune markers (neutrophils, lymphocytes, monocytes, platelets and CRP) and its derived metrics (NLR、PLR、SII、LMR) were analyzed in relation to the following incident ALS by Cox‐proportional hazard models. Subgroup and interaction analyses were performed to explore the covariates of these relationships further.ResultsAfter adjusting for all covariates, the multivariate analysis showed that high neutrophil counts and their derived metrics (NLR, SII) were associated with an increased risk of ALS incidence (per SD increment HR, 95% CI: 1.15, 1.02‐1.29 for neutrophils; 1.15, 1.03‐1.28 for NLR; and 1.17, 1.05‐1.30 for SII). Subgroup and interaction analyses revealed that BMI and age had specific effects on this association. In participants with BMI≥25 or age<65, higher neutrophil counts and their metrics increased the risk of incident ALS; however, in participants with BMI<25 or age≥65, neutrophils had no effect on incident ALS.InterpretationOur study provides evidence that increased neutrophil levels and neutrophil‐derived metrics (NLR and SII) are associated with an increased risk of developing ALS.This article is protected by copyright. All rights reserved.

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“…One could conclude that in the absence of immunosenescence, not all aspects of immunity are compromised, but it may be that specific aspects of caregiving not just the role per se are important influencers of immunity. For example, particular aspects of the caregiving experience may influence or accelerate immune ageing as studies showed increased caregiver burden in young and older caregivers [7] and parental stress in younger caregivers [8] related to poorer neutrophil phagocytosis (ingestion) and superoxide production [7] and more advanced T cell differentiation [8], both associated with immune ageing. Further, these findings highlight potential mechanisms by which some caregivers might report poorer health given that poor sleep quality [7], and less exercise, smoking, and an unbalanced diet, as well as higher BMI [6] related to immune outcomes across studies.…”

Section: Effects Of Caregiving Among Younger Caregivers -Specific Aspmentioning

confidence: 99%

Caregiving alters immunity and stress hormones: a review of recent research

Whittaker

Gallagher

2019

Current Opinion in Behavioral Sciences

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Older caregivers of dementia patients have been studied as a model of chronic stress influencing psychological and physical well-being and the function of the immune system. These immune decrements can relate to altered stress hormone levels, and caregivers show elevated or reduced cortisol compared to age-matched controls as well as dysregulation in other cortisol indices. Recently, this field has developed to examine a range of immune outcomes and cortisol measures in younger caregivers too, as well as other potential underlying mechanisms including genetic variation, acute stress reactivity, and inflammation. Several interventions have also been trialled to reduce the negative physical impact of caregiving stress. This paper reviews the latest developments in the field and gives suggestions for future research.

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Neutrophil function in young and old caregivers

Cited by 9 publications

References 64 publications

Biological Consequences of Psychological Distress in Caregivers of Children with Autism Spectrum Disorder and its Potential Relevance to Other Chronic Diseases Including Cancer

Biological Consequences of Psychological Distress in Caregivers of Children with Autism Spectrum Disorder and its Potential Relevance to Other Chronic Diseases Including Cancer

Neutrophils Are Associated with Higher Risk of Incident Amyotrophic Lateral Sclerosis in a BMI‐ and Age‐Dependent Manner

Caregiving alters immunity and stress hormones: a review of recent research

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