Neutrophil function in Wheelchair Basketball players With Paraplegia

Levada‐Pires, Adriana Cristina; Santos, Vinicius Rocha; Marques, Camila Garcia; Alves, Sílvia Marinho Martins; Curi, Rui; Pithon‐Curi, Tania C.; Cury-Boaventura, Maria Fernanda

doi:10.1249/01.mss.0000384654.62019.ac

Cited by 1 publication

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“…Marques et al [ 86 ] investigated the effects of docosahexaenoic acid (DHA)-rich fish oil (FO) supplementation (3 g/day for 30 days) on neutrophil function in a sample of eight male wheelchair basketball players before and after acute exercise. In the absence of DHA-rich FO supplementation, acute exercise was found to lead to the loss of membrane integrity, ROS production, and high mitochondrial membrane potential in neutrophils, and reduced the phagocytic capacity and IL-6 production by the neutrophils, confirming the results of the previous study by Levada-Pires et al [ 73 ]. These effects could be counteracted by FO supplementation.…”

Section: Resultssupporting

confidence: 88%

“…For example, Levada-Pires et al [ 73 ] recruited a sample of 10 male wheelchair basketballers aged 33.8 ± 2.7 years with a spinal cord injury (at T1-L3). Neutrophil levels and function were assessed on rest and 60 min after the basketball match.…”

Section: Resultsmentioning

confidence: 99%

“…Of interest, in spinal cord injury, Levada-Pires et al [ 73 ] reported decreased phagocytic activity in response to intense physical activity with increased ROS production. Similarly, Marques et al [ 86 ] reported an increase in ROS but also lower phagocytic capacity and IL-6 production.…”

Section: Discussionmentioning

confidence: 99%

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Immunological Response to Exercise in Athletes with Disabilities: A Narrative Review of the Literature

2023

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For a person with a disability, participating in sports activities and/or competitions can be a challenge for the immune system. The relationship between exercise and immunity response in disabled athletes is, indeed, extremely complex for several reasons, including (1) the chronic low-grade inflammatory and immunodepression—“secondary immune deficiency”—state imposed by the disability/impairment; (2) the impact of the disability on an array of variables, spanning from physical fitness to well-being, quality of life, sleep, and nutritional aspects, among others, which are known to mediate/modulate the effects of exercise on human health; (3) the variability of the parameters related to the exercise/physical activity (modality, frequency, intensity, duration, training versus competition, etc.); and (4) the intra- and inter-individual variability of the immunological response to exercise. In able-bodied athletes, previously published data described several exercise-induced changes affecting various immunological subsets and subpopulations, ranging from neutrophils to lymphocytes, and monocytes. Broadly, moderate intensity workout is accompanied by optimal immunity and resistance to infections such as upper respiratory tract infections (URTI) in athletes. Periods of intense training with insufficient recovery can cause a temporary state of immunosuppression, which should end with a few days of rest/recovery from exercise. Disabled athletes are relatively overlooked and understudied with respect to their able-bodied counterparts. Findings from the few studies available on paralympic and disabled athletes are here summarized and analyzed utilizing a narrative approach to review and determine the major features of the immunological and inflammatory responses to exercise in this specific population. Moreover, a few studies have reported behavioral, dietary, and training strategies that can be adopted to limit exercise-induced immunosuppression and reduce the risk of infection in people with disabilities. However, given the paucity of data and contrasting findings, future high-quality investigations on paralympic and disabled athletes are urgently needed.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%