Neutrophil Extracellular Vesicles and Airway Smooth Muscle Proliferation in the Natural Model of Severe Asthma in Horses

Mainguy-Seers, Sophie; Beaudry, Francis; Fernández-Prada, Christopher; Martin, James G.; Lavoie, Jean‐Pierre

doi:10.3390/cells11213347

Cited by 2 publications

(2 citation statements)

References 74 publications

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“…The studies aiming at investigating EVs released from neutrophils are scarce in asthma. Nevertheless, emerging evidence suggests that neutrophil-derived EV might promote the growth of airway smooth muscle cells, thus favoring airway remodeling, as suggested by co-cultures of neutrophil-derived exosomes and smooth muscle cells in a natural model of equine asthma [105,123].…”

Section: Immune Cellsmentioning

confidence: 99%

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Extracellular Vesicles (EVs) as Crucial Mediators of Cell-Cell Interaction in Asthma

Tinè

Padrin

Bonato

et al. 2023

IJMS

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Asthma is the most common chronic respiratory disorder worldwide and accounts for a huge health and economic burden. Its incidence is rapidly increasing but, in parallel, novel personalized approaches have emerged. Indeed, the improved knowledge of cells and molecules mediating asthma pathogenesis has led to the development of targeted therapies that significantly increased our ability to treat asthma patients, especially in severe stages of disease. In such complex scenarios, extracellular vesicles (EVs i.e., anucleated particles transporting nucleic acids, cytokines, and lipids) have gained the spotlight, being considered key sensors and mediators of the mechanisms controlling cell-to-cell interplay. We will herein first revise the existing evidence, mainly by mechanistic studies in vitro and in animal models, that EV content and release is strongly influenced by the specific triggers of asthma. Current studies indicate that EVs are released by potentially all cell subtypes in the asthmatic airways, particularly by bronchial epithelial cells (with different cargoes in the apical and basolateral side) and inflammatory cells. Such studies largely suggest a pro-inflammatory and pro-remodelling role of EVs, whereas a minority of reports indicate protective effects, particularly by mesenchymal cells. The co-existence of several confounding factors—including technical pitfalls and host and environmental confounders—is still a major challenge in human studies. Technical standardization in isolating EVs from different body fluids and careful selection of patients will provide the basis for obtaining reliable results and extend their application as effective biomarkers in asthma.

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Section: Immune Cellsmentioning

confidence: 99%

“…[ 105,123] Dendritic cells EVs secreted by dendritic cells (DC) induce antigen-specific CD8 + T-cells and antigen-specific IgG production.…”

Section: Other Non-immune Cellsmentioning

confidence: 99%

Extracellular Vesicles (EVs) as Crucial Mediators of Cell-Cell Interaction in Asthma

Tinè

Padrin

Bonato

et al. 2023

IJMS

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Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease

Rumpf,

Pautz,

Drebes

et al. 2023

IJMS

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Microtubule-Associated Serine/Threonine (MAST) kinases represent an evolutionary conserved branch of the AGC protein kinase superfamily in the kinome. Since the discovery of the founding member, MAST2, in 1993, three additional family members have been identified in mammals and found to be broadly expressed across various tissues, including the brain, heart, lung, liver, intestine and kidney. The study of MAST kinases is highly relevant for unraveling the molecular basis of a wide range of different human diseases, including breast and liver cancer, myeloma, inflammatory bowel disease, cystic fibrosis and various neuronal disorders. Despite several reports on potential substrates and binding partners of MAST kinases, the molecular mechanisms that would explain their involvement in human diseases remain rather obscure. This review will summarize data on the structure, biochemistry and cell and molecular biology of MAST kinases in the context of biomedical research as well as organismal model systems in order to provide a current profile of this field.

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Neutrophil Extracellular Vesicles and Airway Smooth Muscle Proliferation in the Natural Model of Severe Asthma in Horses

Cited by 2 publications

References 74 publications

Extracellular Vesicles (EVs) as Crucial Mediators of Cell-Cell Interaction in Asthma

Extracellular Vesicles (EVs) as Crucial Mediators of Cell-Cell Interaction in Asthma

Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease

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