Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases

Salazar-González, Hector; Zepeda-Hernandez, Alexa; Melo, Zesergio; Saavedra-Mayorga, Diego Eduardo; Echavarría, Raquel

doi:10.3390/medicina55080431

Cited by 26 publications

(28 citation statements)

References 131 publications

(225 reference statements)

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“…Interestingly, the same effects were identified in patients (51). In a recent review, Hector Salazar-Gonzalez and colleagues examined the role of NETs in renal diseases, highlighting the necessity to block NET formation to interfere with the pathogenesis of inflammatory and non-inflammatory diseases, including cancer (70). Finally, beyond the role of NETs as a possible therapeutic target in cancer, a direct therapeutic role of NETs has been reported in bladder cancer.…”

Section: Nets As Potential Targets In Cancer Therapymentioning

confidence: 81%

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

et al. 2020

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Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to their key role in the neutrophil innate immune response, NETs are also involved in autoimmune diseases, like systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and in other non-infectious pathological processes, as coagulation disorders, thrombosis, diabetes, atherosclerosis, vasculitis, and cancer. Recently, a large body of evidence indicates that NETs are involved in cancer progression and metastatic dissemination, both in animal models and cancer patients. Interestingly, a close correlation between cancer cell recruitment of neutrophils in the tumor microenvironment (Tumor Associated Neutrophils. TANs) and NET formation has been also observed either in primary tumors and metastatic sites. Moreover, NETs can also catch circulating cancer cells and promote metastasis. Furthermore, it has been reported that wake dormant cancer cells, causing tumor relapse and metastasis. This review will primarily focus on the pro-tumorigenic activity of NETs in tumors highlighting their ability to serve as a potential target for cancer therapy.

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Section: Nets As Potential Targets In Cancer Therapymentioning

confidence: 81%

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

et al. 2020

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“…Chronic kidney disease is another common outcome in COVID-19 [ 117 ]: as NETs are thought to drive kidney pathology in other diseases, they are likely to contribute to renal failure via immunothrombosis in COVID-19 [ 118 , 119 ]. It is not yet clear what causes NETosis in COVID-19, though viral-induced cell death, DAMP release (e.g.…”

Section: Introductionmentioning

confidence: 99%

Innate immunology in COVID-19—a living review. Part II: dysregulated inflammation drives immunopathology

Prs.

Alrubayyi

Pring

et al. 2020

Oxford Open Immunology

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The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a global health crisis and will likely continue to impact public health for years. As the effectiveness of the innate immune response is crucial to patient outcome, huge efforts have been made to understand how dysregulated immune responses may contribute to disease progression. Here we have reviewed current knowledge of cellular innate immune responses to SARS-CoV-2 infection, highlighting areas for further investigation and suggesting potential strategies for intervention. We conclude that in severe COVID-19 initial innate responses, primarily type I interferon, are suppressed or sabotaged which results in an early interleukin (IL)-6, IL-10 and IL-1β-enhanced hyperinflammation. This inflammatory environment is driven by aberrant function of innate immune cells: monocytes, macrophages and natural killer cells dispersing viral pathogen-associated molecular patterns and damage-associated molecular patterns into tissues. This results in primarily neutrophil-driven pathology including fibrosis that causes acute respiratory distress syndrome. Activated leukocytes and neutrophil extracellular traps also promote immunothrombotic clots that embed into the lungs and kidneys of severe COVID-19 patients, are worsened by immobility in the intensive care unit and are perhaps responsible for the high mortality. Therefore, treatments that target inflammation and coagulation are promising strategies for reducing mortality in COVID-19.

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“…However, not only equine endometrosis seems to be affected by profibrotic effects of NETs. Hepatic [ 47 ], cardiac [ 48 ] and renal [ 49 ] fibrosis was also linked to NETs persistence. Recently, NETs were found in the lungs of a cystic fibrosis mouse model in the absence of bacterial infection [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Noscapine Acts as a Protease Inhibitor of In Vitro Elastase-Induced Collagen Deposition in Equine Endometrium

Amaral

Fernandes

Szóstek‐Mioduchowska

et al. 2021

IJMS

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Endometrosis is a reproductive pathology that is responsible for mare infertility. Our recent studies have focused on the involvement of neutrophil extracellular traps enzymes, such as elastase (ELA), in the development of equine endometrosis. Noscapine (NOSC) is an alkaloid derived from poppy opium with anticough, antistroke, anticancer, and antifibrotic properties. The present work investigates the putative inhibitory in vitro effect of NOSC on collagen type I alpha 2 chain (COL1A2) mRNA and COL1 protein relative abundance induced by ELA in endometrial explants of mares in the follicular or mid-luteal phases at 24 or 48 h of treatment. The COL1A2 mRNA was evaluated by qPCR and COL1 protein relative abundance by Western blot. In equine endometrial explants, ELA increased COL 1 expression, while NOSC inhibited it at both estrous cycle phases and treatment times. These findings contribute to the future development of new endometrosis treatment approaches. Noscapine could be a drug capable of preventing collagen synthesis in mare’s endometrium and facilitate the therapeutic approach.

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Neutrophil Extracellular Traps in the Establishment and Progression of Renal Diseases

Cited by 26 publications

References 131 publications

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

Innate immunology in COVID-19—a living review. Part II: dysregulated inflammation drives immunopathology

Noscapine Acts as a Protease Inhibitor of In Vitro Elastase-Induced Collagen Deposition in Equine Endometrium

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