Neutrophil extracellular traps in acute coronary syndrome

Abstract

Acute coronary syndrome (ACS) is a group of clinical syndromes caused by acute myocardial ischemia, which can cause heart failure, arrhythmia and even sudden death. It is the major cause of disability and death worldwide. Neutrophil extracellular traps (NETs) are reticular structures released by neutrophils activation and have various biological functions. NETs are closely related to the occurrence and development of ACS and also the subsequent damage after myocardial infarction. The mechanisms are complex and interdependent on various pathways, which require further exploration. This article reviewed the role and mechanism of NETs in ACS, thereby providing a valuable reference for the diagnosis and clinical treatment of ACS.

Identification and Validation of Hub Genes Related to Neutrophil Extracellular Traps-Mediated Cell Damage During Myocardial Infarction

“…NETs are reticular structures released by neutrophil activation and are closely related to the subsequent damage after MI. 17 NETs are involved in the inflammatory pathophysiology of a variety of illnesses, such as cardiovascular and infectious diseases. 25 PMA can induce neutrophil aggregation and subsequent NETs release.…”

“… 16 For example, one study found that in addition to providing a scaffold for thrombus formation, NETs formation also exacerbates endothelial cell injury, which may be an important contributor to the development of MI. 17 …”

COVID-19 and the risk of acute cardiovascular diseases: A two-sample Mendelian randomization study

“…During NETosis, autoantigens, proin ammatory mediators, proteases, and cytotoxic enzymes are exposed, leading to cytokine storm [50]. Recent studies have highlighted that neutrophil-induced NETs are central to the development of cytokine storm and immunopathological complications such as deep vein thrombosis, myocardial infarction, and thrombotic microangiopathy [51][52][53]. Interactions between activated neutrophils, platelets, and coagulation cascade are important in the process of thrombosis in COVID-19 [54].…”

Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting

“…The various pathomechanisms of NETs in atherosclerosis and thrombosis may also contribute to the development of MI [52,53]. Furthermore, granular proteins (NET components) can recruit monocytes to the culprit site by triggering monocyte chemoattractant protein 1 release from local ECs [54].…”