Neutrophil extracellular traps are increased in cancer patients but does not associate with venous thrombosis

Öklü, Rahmi; Sheth, Rahul A.; Wong, Keith H.K.; Jahromi, Amin Haghighat; Albadawi, Hassan

doi:10.21037/cdt.2017.08.01

Cited by 70 publications

(53 citation statements)

References 37 publications

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“…NETs have been correlated to cancer progression and metastatic spread also in human tumors. Levels of NETs in plasma of patients with different types of tumors including lung, pancreatic, and bladder cancer, were found to be higher than in healthy controls (57). In lung cancer patients, Li et al demonstrated the presence of NETs in lung tissues, peripheral blood, and sputum (52).…”

Section: Nets In Cancer Patientsmentioning

confidence: 99%

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

et al. 2020

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Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to their key role in the neutrophil innate immune response, NETs are also involved in autoimmune diseases, like systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and in other non-infectious pathological processes, as coagulation disorders, thrombosis, diabetes, atherosclerosis, vasculitis, and cancer. Recently, a large body of evidence indicates that NETs are involved in cancer progression and metastatic dissemination, both in animal models and cancer patients. Interestingly, a close correlation between cancer cell recruitment of neutrophils in the tumor microenvironment (Tumor Associated Neutrophils. TANs) and NET formation has been also observed either in primary tumors and metastatic sites. Moreover, NETs can also catch circulating cancer cells and promote metastasis. Furthermore, it has been reported that wake dormant cancer cells, causing tumor relapse and metastasis. This review will primarily focus on the pro-tumorigenic activity of NETs in tumors highlighting their ability to serve as a potential target for cancer therapy.

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Section: Nets In Cancer Patientsmentioning

confidence: 99%

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

et al. 2020

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“…Multiple studies illustrated the trapping of circulating murine tumor cells in NETs, which facilitated their extravasation and metastasis ( 42 – 44 ). Increased levels of NETs were also observed in patients suffering from different types of locally infiltrating cancer ( 45 , 46 ), which was associated with adverse patient outcomes in colorectal cancer ( 47 ).…”

Section: Role Of Neutrophils In Tumor Progressionmentioning

confidence: 99%

Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance

et al. 2020

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Over the last decades, cancer immunotherapies such as checkpoint blockade and adoptive T cell transfer have been a game changer in many aspects and have improved the treatment for various malignancies considerably. Despite the clinical success of harnessing the adaptive immunity to combat the tumor, the benefits of immunotherapy are still limited to a subset of patients and cancer types. In recent years, neutrophils, the most abundant circulating leukocytes, have emerged as promising targets for anti-cancer therapies. Traditionally regarded as the first line of defense against infections, neutrophils are increasingly recognized as critical players during cancer progression. Evidence shows the functional plasticity of neutrophils in the tumor microenvironment, allowing neutrophils to exert either pro-tumor or anti-tumor effects. This review describes the tumor-promoting roles of neutrophils, focusing on their myeloid-derived suppressor cell activity, as well as their role in tumor elimination, exerted mainly via antibody-dependent cellular cytotoxicity. We will discuss potential approaches to therapeutically target neutrophils in cancer. These include strategies in humans to either silence the pro-tumor activity of neutrophils, or to activate or enhance their anti-tumor functions. Redirecting neutrophils seems a promising approach to harness innate immunity to improve treatment for cancer patients.

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“…Furthermore, it has been determined that NETs are involved in a variety of conditions such as cancers and vascular diseases like atherosclerosis, small vessel vasculitis (SVV), and thrombosis [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Imaging of Neutrophil Extracellular Traps (NETs): Visualization Methods and Outcomes

Alasmari

2020

BioMed Research International

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Neutrophils comprise the first line of innate immune defense during a host-pathogen interaction. ey attack microorganisms directly through three different methods, of which, phagocytosis and degranulation have been known and well-studied for decades. e formation of neutrophil extracellular traps (NETs) is the third and unique method, which was unveiled in 2004. Since then, many studies on NETs have been carried out. However, only few have successfully demonstrated the activity of NETs in vivo. Results of the in vivo studies on NETs have strengthened our understanding of their role in different situations. is review highlights the main in vivo studies, which have contributed in extending our understanding of the role of NETs during infections and diseases, thus indicating their advantages and limitations.

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Neutrophil extracellular traps are increased in cancer patients but does not associate with venous thrombosis

Abstract: Further studies are warranted to determine the role of NETs as a procoagulant in human thrombosis.

Cited by 70 publications

References 37 publications

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis

Plasticity in Pro- and Anti-tumor Activity of Neutrophils: Shifting the Balance

In Vivo Imaging of Neutrophil Extracellular Traps (NETs): Visualization Methods and Outcomes

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