Neutrophil Expression of Cyclooxygenase 2 in Preeclampsia

Bachawaty, Teddi; Washington, Sonya L.; Walsh, Scott W.

doi:10.1177/1933719110361960

Cited by 21 publications

(18 citation statements)

References 31 publications

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“…COX-2 is the important rate-limiting enzyme that is synthesized by prostaglandin (PG), which is associated with inflammation and atherosclerosis ( 18 ). PG is a type of important tissue-derived medium, and the vasoactive PG products, such as angiotensin and thromboxane, play key roles in vascular endothelial injury and thrombosis ( 19 ).…”

Section: Discussionmentioning

confidence: 99%

Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy

Qian

Fan

et al. 2017

Exp Ther Med

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In the present study, we studied the influence of serum high-molecular weight adiponectin (HMWA) levels in patients with pregnancy-induced hypertension (PIH) on the occurrence of eclampsia in secondary pregnancy and its related mechanisms. In total, 130 patients who were diagnosed with PIH for the first time were selected for this study; the median interval of the secondary pregnancy was 28.5 months. The serum HMWA and leptin levels both times were detected, and the insulin resistance indexes (HOMA-IR) were calculated. The serum inflammatory indexes in the secondary pregnancy included interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) levels, and the oxidative stress indexes included methane dicarboxylic aldehyde (MDA) and oxidized low-density lipoprotein (ox-LDL) levels. The expression levels of adiponectin receptor 2 and cyclooxygenase-2 (COX-2) in placental tissue were detected. In secondary pregnancy, there were a total of 20 cases of eclampsia (15.38%), including 2 cases of mild PIH, 8 cases of moderate PIH and 10 cases of severe PIH; differences were statistically significant when compared to patients without eclampsia (p<0.001). The serum HMWA levels in patients with severe PIH in the first pregnancy were significantly lower than those in patients with mild and moderate PIH, and the serum levels in patients with mild PIH were the highest. The leptin levels in patients with severe PIH were significantly higher than those in patients with mild and moderate PIH, and the leptin levels in patients with mild PIH were the lowest (p<0.05). The HMWA levels in patients with eclampsia in the secondary pregnancy was significantly lower than those in patients without eclampsia, and the leptin levels in patients with eclampsia were significantly increased. The HMWA levels in patients with eclampsia in the secondary pregnancy were lower than that in the first pregnancy, whereas the leptin levels were higher than that in the first pregnancy (p<0.05). HOMA-IR, IL-6, TNF-α, MDA and ox-LDL levels in patients with eclampsia were significantly higher than those in patients without eclampsia (p<0.05), and the adiponectin receptor 2 and COX-2 expression levels in the placental tissue were significantly higher than those in patients without eclampsia (p<0.05). Therefore, the serum HMWA levels are closely related to the occurrence of eclampsia in PIH patients in secondary pregnancy, and it influences insulin resistance, inflammatory response and oxidative stress response, which is correlated with increased adiponectin receptor 2 and COX-2 protein expression in placental tissue. Consequently, HMWA may be an important target for the intervention of preventing eclampsia for PIH patients in secondary pregnancy.

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Section: Discussionmentioning

confidence: 99%

Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy

Qian

Fan

et al. 2017

Exp Ther Med

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“…16 Thus, neutrophils obtained from pre-eclamptic females express significantly more COX-2 than healthy pregnant females or healthy non-pregnant females. 17 Another theory proposed that the activation of neutrophils occurs in placental circulation under hypoxic conditions that contribute to increased vascular resistance in pre eclamptic pregnancies. 18 It was also found that there was more neutrophil endothelial adhesion and infiltration into intimal space in systemic vasculature while lymphocyte infiltration was not significant.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil Lymphocyte Ratio (NLR) as a Bio Inflammatory Marker in Pre-eclampsia

Singhal¹,

Pal²,

Tiwari³

et al. 2019

IJCMR

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Introduction: Pre-eclampsia, a systemic disease unique to pregnancy, affects 3-14% of pregnant women. The aim of the present study was to evaluate Neutrophil Lymphocyte Ratio (NLR) as a bio inflammatory marker of pre-eclampsia (PE), a hypertensive disorder of pregnancy characterized by hypertension and proteinuria after 20 weeks of gestation. Material and Methods: This case control study was carried out over a period of 10 months after informed consent and ethical clearance. The study population included 70 pregnant women (35 pre-eclampsia cases and 35 normotensive pregnant subjects as controls). 3 ml venous blood samples were obtained from both the cases and controls. Complete blood count was done using semi-automated three part haematology analyser which gives the reading of cell counts, NLR was calculated manually. Results: The case group (subjects with pre-eclampsia) were found to have higher neutrophil to lymphocyte ratio (NLR) than that of the control group. This difference was statistically significant (p<0.001). The receiver operating curve (ROC) analysis showed significant diagnostic accuracy of NLR to discriminate cases and controls (area under the curve [AUC] = 0.73, P < 0.001) at cutoff value of >= 4.86, 68.6% sensitivity and 80% specificity. Conclusion: Unlike many other inflammatory markers, NLR proves to be an inexpensive and readily available biomarkers, obtained from routinely done complete blood counts that may be useful for prediction and diagnosis of pre-eclampsia.

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“…Therefore, COX-2 and mPGES-1 may induce muscle pain through PGE 2 production. In inflammation, COX-2 is expressed in neutrophils, macrophages, endothelial cells, and muscle nuclei/muscle satellite cells [ 11 , 27 , 28 ]. mPGES-1 has been reported to be localized in macrophages and fibroblasts during inflammation [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Preconditioning Contractions Suppress Muscle Pain Markers after Damaging Eccentric Contractions

Nagahisa

Ikezaki

Yamada

et al. 2018

Pain Research and Management

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Inexperienced vigorous exercise, including eccentric contraction (ECC), causes muscle pain and damage. Similar prior light exercise suppresses the development of muscle pain (repeated-bout effect), but the molecular mechanisms behind this are not sufficiently understood. In this study, the influence of a nondamaging preconditioning ECC load (Precon) on muscle pain-related molecules and satellite cell-activating factors was investigated at the mRNA expression level. Nine-week-old male Wistar rats (n=36) were divided into 2 groups: a group receiving only a damaging ECC (100 contractions) load (non-Precon) and a group receiving a nondamaging ECC (10 contractions) load 2 days before receiving the damaging ECC load (Precon). ECC was loaded on the left leg, and the right leg was regarded as the intact control (CTL). The medial head of the gastrocnemius muscle from all rats was excised 2 or 4 days after the damaging ECC loading, and the relative mRNA expression levels of muscle pain- and satellite cell-related molecules were quantitated using real-time RT PCR. Precon suppressed increases in MHC-embryonic and MHC-neonatal mRNA expressions. Enhancement of HGF, Pax7, MyoD, and myogenin mRNA expression was also suppressed, suggesting that Precon decreased the degree of muscle damage and no muscle regeneration or satellite cell activation occurred. Similarly, increases in mRNA expression of muscle pain-related molecules (BKB2 receptor, COX-2, and mPGEC-1) were also suppressed. This study clearly demonstrated that at the mRNA level, prior light ECC suppressed muscle damage induced by later damaging ECC and promoted recovery from muscle pain.

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Neutrophil Expression of Cyclooxygenase 2 in Preeclampsia

Cited by 21 publications

References 31 publications

Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy

Influence of serum HMW adiponectin level in patients with pregnancy-induced hypertension syndrome on the occurrence of eclampsia in secondary pregnancy

Neutrophil Lymphocyte Ratio (NLR) as a Bio Inflammatory Marker in Pre-eclampsia

Preconditioning Contractions Suppress Muscle Pain Markers after Damaging Eccentric Contractions

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