Neutrophil Emigration and Microvascular Injury

Movat, Henry Z.; Cybulsky, Myron I.

doi:10.1159/000157043

Cited by 24 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The baseline values were taken from identical experiments in our laboratory and reported by Mileski et al (22). Leukocyte accumulation was similar to that observed in other inflammatory processes (3,4,25). Mononuclear leukocytes in the peritoneum 4 h after instillation of protease peptone was > 3.5 times greater than in normal rabbits (22) and continued to increase over the next 20 h to -9.5 times the 4-h value.…”

Section: Resultssupporting

confidence: 83%

CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.

Winn

Harlan²

1993

J. Clin. Invest.

View full text Add to dashboard Cite

The CD18 mAb 60.3 and the CD49d mAb HP1 /2 were given at the time of intraperitoneal instillation of either protease peptone or live Escherichia coli bacteria and at 12 h. Leukocyte emigration was evaluated at 4 and 24 h. PMN emigration 4 h after protease peptone instillation and injection of both mAbs was 10% of that in saline treatment. It was 15% of that in saline treatment after mAb 60.3 alone and unchanged by mAb HP1 / 2. At 24 h PMN emigration in response to protease peptone was not prevented by either CD18 or CD49d mAbs, however, when given together emigration was 10% of saline-treated animals. Mononuclear cell emigration to protease peptone was enhanced at 4 h by both CD18 and CD49d mAbs. The CD18 mAb did not augment mononuclear emigration in response to live bacteria. At 24 h, neither the CD18 nor the CD49d mAb alone blocked emigration ofmononuclear cells, but the combination of the two did. These studies demonstrate that: (a) early (4 h) PMN emigration is CD11 /CD18 dependent; (b) late (24 h) PMN emigration is CD1 1 /CD18 independent; and (c) mononuclear cells utilize the integrins CD18 and CD49d. (J.

show abstract

Section: Resultssupporting

confidence: 83%

CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.

Winn

Harlan²

1993

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

Tumor Necrosis Factor and Interleukin 1 Appearance in Experimental Gram-negative Septic Shock

Busund

Lindsetmo²,

Rasmussen³

et al. 1991

Arch Surg

View full text Add to dashboard Cite

To study the effect of plasma removal vs plasma administration on the appearance of tumor necrosis factor (TNF) and interleukin 1 in septic shock, 24 anesthetized piglets were inoculated with live Escherichia coli. Plasma exchange with albumin was performed in one group. Fresh-frozen plasma was administered to a second group. A third group served as nontreated controls. Following plasma exchange, a reduction in both TNF and interleukin 1 levels occurred, whereas plasma infusion was followed by a decrease in TNF levels only. No significant differences were observed between the two treated groups with respect to survival or cardiovascular performance, with both being significantly enhanced compared with the controls. High levels of TNF and interleukin 1 correlated with depressed cardiovascular performance in the early phase of the shock. Our results confirm the important role of TNF and interleukin 1 as early mediators of septic shock. However, the benefit of reducing cytokine activity in later stages of septicemia seems to be dubious.

show abstract

Anti-Neutrophil Antibody Attenuates the Severity of Acute Lung Injury in Rats With Experimental Acute Pancreatitis

Inoue

Nakao²,

Kishimoto³

et al. 1995

Arch Surg

View full text Add to dashboard Cite

show abstract

Neutrophil Emigration and Microvascular Injury

Cited by 24 publications

References 31 publications

CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.

CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits.

Tumor Necrosis Factor and Interleukin 1 Appearance in Experimental Gram-negative Septic Shock

Anti-Neutrophil Antibody Attenuates the Severity of Acute Lung Injury in Rats With Experimental Acute Pancreatitis

Contact Info

Product

Resources

About