2018
DOI: 10.1186/s40478-018-0576-3
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Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury

Abstract: After spinal cord injury (SCI), neutrophil elastase (NE) released at injury site disrupts vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are vascular growth factors that play an important role in vascular stabilization. We hypothesized that neutrophil elastase is one of the key determinants of vascular endothelium disruption/destabilization and affects angiopoietins expression after spinal cord injury. To test this, tubule formation and angiopoietins expression were assessed in endoth… Show more

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Cited by 43 publications
(33 citation statements)
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“…Interestingly, elastase promotes fibrosis in lung disease 31 . Elastase inhibition decreases scar formation after spinal cord injury 32 . In line with the above observations, NETs increased the protein level of elastase in macrophages (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Interestingly, elastase promotes fibrosis in lung disease 31 . Elastase inhibition decreases scar formation after spinal cord injury 32 . In line with the above observations, NETs increased the protein level of elastase in macrophages (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…SCI induces an increase in the expression of pro-in ammatory cytokines (TNF-α, IL-6, and IL-1β), while it decreases the expression of the anti-in ammatory cytokine IL-10 [38] . As shown in the study by Cheng et al [5] , the NSC medium was able to suppress the expression of the pro-in ammatory cytokine IL-6.…”
Section: Discussionmentioning
confidence: 99%
“…Its involvement may be direct (tissue damage) or indirect (proinflammatory or proapoptotic) [26][27][28]. However, it is undeniable that elastase is a necessary condition for neutrophil migration to inflammatory sites, and the proteolytic activity of elastase contributes to the body's defence against infectious agents by promoting the destruction of pathogenic bacteria [29][30][31]. Our results show that Emo at the concentration of 10 μM and 20 μM can promote granulocytes elastase release induced by fMLP.…”
Section: Discussionmentioning
confidence: 69%