Neutrophil dysfunctions in sickle cell disease

Humbert, J. R.; Winsor, EL; Githens, John H.; Schmitz, JB

doi:10.1016/0753-3322(90)90002-q

Cited by 21 publications

(14 citation statements)

References 24 publications

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“…Neutrophil dysfunction was considered a very important functional defect involved in the high susceptibility to infections53. For example, neutrophils from SCD patients show high expression of CD18, a molecule correlated with adhesive properties, and they respond, in vitro, to IL-8 with enhanced sensitivity54.…”

Section: Etiology Of Risks Of Infections In Thalassemia and Hemoglobimentioning

confidence: 99%

Infections in Thalassemia and Hemoglobinopathies

Ricerca¹,

Girolamo²,

Rund³

2009

Medit J Hemat Infect Dis

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The clinical approach to thalassemia and hemoglobinopathies, specifically Sickle Cell Disease (SCD), based on transfusions, iron chelation and bone marrow transplantation has ameliorated their prognosis. Nevertheless, infections still may cause serious complications in these patients. The susceptibility to infections in thalassemia and SCD arises both from a large spectrum of immunological abnormalities and from exposure to specific infectious agents. Four fundamental issues will be focused upon as central causes of immune dysfunction: the diseases themselves; iron overload, transfusion therapy and the role of the spleen. Thalassemia and SCD differ in their pathogenesis and clinical course. It will be outlined how these differences affect immune dysfunction, the risk of infections and the types of most frequent infections in each disease. Moreover, since transfusions are a fundamental tool for treating these patients, their safety is paramount in reducing the risks of infections. In recent years, careful surveillance worldwide and improvements in laboratory tests reduced greatly transfusion transmitted infections, but the problem is not completely resolved. Finally, selected topics will be discussed regarding Parvovirus B19 and transfusion transmitted infections as well as the prevention of infectious risk postsplenectomy or in presence of functional asplenia.

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Section: Etiology Of Risks Of Infections In Thalassemia and Hemoglobimentioning

confidence: 99%

Infections in Thalassemia and Hemoglobinopathies

Ricerca¹,

Girolamo²,

Rund³

2009

Medit J Hemat Infect Dis

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“…The suggestion that poor bactericidal activity of neutrophils may contribute to infection susceptibility in SCD is not entirely new, 49 and defects have been demonstrated in the oxidative burst response in adults with SCD, 50 although the role of hemolysis has not previously been explored. Our study confirms that this defect is seen in a very well defined group of children with HbSS SCD, and is not confounded by the effect of blood transfusion or disease modifying therapy.…”

Section: A B Cmentioning

confidence: 99%

Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1

et al. 2015

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“…S . Typhimurium bacteremia is also associated with other conditions resulting in a reduced microbicidal activity of neutrophils (Humbert et al, 1990; Tauber et al, 1983), including chronic granulomatous disease (Winkelstein et al, 2000) and sickle cell anaemia (Okuonghae et al, 1993). …”

Section: Inducible Mucosal Barrier Functions and The Consequences Of mentioning

confidence: 99%

The Blessings and Curses of Intestinal Inflammation

Winter

Keestra

Tsolis

et al. 2010

Cell Host & Microbe

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SUMMARY The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction against microbiota colonizing the lumen. Adequate inflammatory responses against bacterial invasion result in the luminal secretion of antimicrobial peptides, as well as the release of cytokines in tissue that recruit and activate phagocytes. However, pathogens have evolved to utilize these environmental changes in the inflamed intestine to promote colonization. This review focuses on the costs and benefits of intestinal inflammation and the fine interplay between the host, its microbiota and enteric pathogens.

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Neutrophil dysfunctions in sickle cell disease

Cited by 21 publications

References 24 publications

Infections in Thalassemia and Hemoglobinopathies

Infections in Thalassemia and Hemoglobinopathies

Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1

The Blessings and Curses of Intestinal Inflammation

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