Neutrophil dysfunction varies with the stage of canine visceral leishmaniosis

Almeida, Breno Fernando Martins de; Narciso, Luı́s; Bosco, Álvaro Francisco; Pereira, Paulo Roberto Mendes; Braga, Eveline Tozzi; Avanço, Saulo Vinícius; Marcondes, Mary; Ciarlini, Paulo César

doi:10.1016/j.vetpar.2013.02.016

Cited by 28 publications

(18 citation statements)

References 41 publications

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“…The viability of neutrophils decreased in the final stages of the disease and this is thought to have been as a result of uremia (Almeida et al 2013 b ). A similar study also demonstrated that in moderate disease there was increased superoxide production but in very severe stages of disease there was a decrease in superoxide production and increased apoptosis, which was also associated with uremia (Almeida et al 2013 a ). …”

Section: Innate Immune Responsesmentioning

confidence: 80%

Insights on adaptive and innate immunity in canine leishmaniosis

2016

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SUMMARYCanine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities. Clinical manifestations can range from subclinical infection to very severe systemic disease. Leishmaniosis is categorized as a neglected tropical disease and the complex immune responses associated with Leishmania species makes therapeutic treatments and vaccine development challenging for both dogs and humans. In this review, we summarize innate and adaptive immune responses associated with L. infantum infection in dogs, and we discuss the problems associated with the disease as well as potential solutions and the future direction of required research to help control the parasite.

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Section: Innate Immune Responsesmentioning

confidence: 80%

Insights on adaptive and innate immunity in canine leishmaniosis

2016

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“…The suppurative meningomyelitis and bacterial myositis diagnosed in dog 7 was possibly the result of immunosuppression induced by leishmaniasis. In canine visceral leishmaniasis, the parasite survives in the host by modulating its immune system and inducing immunosuppression (Al Mofleh , Buchmuller‐Rouiller & Manuel , Pinelli et al , Almeida et al ). Both the innate and specific immune system appear to be suppressed during Leishmania infections.…”

Section: Discussionmentioning

confidence: 99%

Neurological manifestations in dogs naturally infected by Leishmania infantum: descriptions of 10 cases and a review of the literature

Giannuzzi¹,

Ricciardi²,

Simone³

et al. 2017

J of Small Animal Practice

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In order to evaluate possible nervous system involvement in canine leishmaniasis, retrospective evaluation of all medical records of leishmaniotic dogs exhibiting neurological signs referred to our hospital over a 5-year period was performed. The records of 10 dogs were reviewed. Depending on the neuroanatomical localisation, the dogs underwent advanced diagnostic imaging, cerebrospinal fluid analysis, electrodiagnostic testing and histopathologic evaluations. The final neurological diagnosis was: meningoencephalitis (n=2), brain haemorrhagic stroke (n=1), haemorrhagic choroiditis (n=1), meningomyelitis (n=2), ischaemic myelopathy (n=1), polymyositis (n=2) and peripheral neuropathy (n=1). This study confirms that both central and peripheral nervous systems can be affected by leishmaniasis and provides an overview on the possible etiopathogenetic mechanisms. In addition, clinical and diagnostic findings, therapy and follow-up of affected dogs are described.

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“…Neutrophils from severely affected dogs undergo oxidative burst poorly and are more prone to apoptosis. In contrast, neutrophils from dogs with less severe disease undergo oxidative burst more readily and appear to have improved half‐life .…”

Section: Neutrophils In Visceral Leishmaniasismentioning

confidence: 97%

Permissive and protective roles for neutrophils in leishmaniasis

Carlsen¹,

Liang²,

Shelite³

et al. 2015

Clinical and Experimental Immunology

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Summary Leishmania parasites are the causative agents of leishmaniasis, a neglected tropical disease that causes substantial morbidity and considerable mortality in many developing areas of the world. Recent estimates suggest that roughly 10 million people suffer from cutaneous leishmaniasis (CL), and approximately 76 000 are afflicted with visceral leishmaniasis (VL), which is universally fatal without treatment. Efforts to develop therapeutics and vaccines have been greatly hampered by an incomplete understanding of the parasite's biology and a lack of clear protective correlates that must be met in order to achieve immunity. Although parasites grow and divide preferentially in macrophages, a number of other cell types interact with and internalize Leishmania parasites, including monocytes, dendritic cells and neutrophils. Neutrophils appear to be especially important shortly after parasites are introduced into the skin, and may serve a dual protective and permissive role during the establishment of infection. Curiously, neutrophil recruitment to the site of infection appears to continue into the chronic phase of disease, which may persist for many years. The immunological impact of these cells during chronic leishmaniasis is unclear at this time. In this review we discuss the ways in which neutrophils have been observed to prevent and promote the establishment of infection, examine the role of anti‐neutrophil antibodies in mouse models of leishmaniasis and consider recent findings that neutrophils may play a previously unrecognized role in influencing chronic parasite persistence.

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Neutrophil dysfunction varies with the stage of canine visceral leishmaniosis

Cited by 28 publications

References 41 publications

Insights on adaptive and innate immunity in canine leishmaniosis

Insights on adaptive and innate immunity in canine leishmaniosis

Neurological manifestations in dogs naturally infected by Leishmania infantum: descriptions of 10 cases and a review of the literature

Permissive and protective roles for neutrophils in leishmaniasis

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