Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney

Wang, Zechen; Shen, Jiajia; Ye, Kun; Zhao, Jingjie; Huang, Shaoang; He, Siyuan; Qin, Yuhua; Meng, Lingzhang; Wang, J.; Song, Jian

doi:10.1155/2023/9810733

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Intriguingly, the enhanced nuclear translocation of CaM-KIV in SLE patients fosters CREMα phosphorylation, further contributing to T-cell dysfunction in the disease. [71] Wang et al [72] further revealed that in the context of lupus nephritis, neutrophils secrete IL-6, aiding B cells in resisting ferroptosis by elevating SLC7A11 expression. Notably, both lupus patients and animal models display signs of B-cell ferroptosis.…”

Section: Slementioning

confidence: 99%

Molecular and therapeutic landscape of ferroptosis in skin diseases

Le,

Meng,

Wang

et al. 2024

Chinese Medical Journal

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Regulated cell death (RCD) is a critical physiological process essential in maintaining skin homeostasis. Among the various forms of RCD, ferroptosis stands out due to its distinct features of iron accumulation, lipid peroxidation, and involvement of various inhibitory antioxidant systems. In recent years, an expanding body of research has solidly linked ferroptosis to the emergence of skin disorders. Therefore, understanding the mechanisms underlying ferroptosis in skin diseases is crucial for advancing therapy and prevention strategies. This review commences with a succinct elucidation of the mechanisms that underpin ferroptosis, embarks on a thorough exploration of ferroptosis’s role across a spectrum of skin conditions, encompassing melanoma, psoriasis, systemic lupus erythematosus (SLE), vitiligo, and dermatological ailments precipitated by ultraviolet (UV) exposure, and scrutinizes the potential therapeutic benefits of pharmacological interventions aimed at modulating ferroptosis for the amelioration of skin diseases.

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Section: Slementioning

confidence: 99%

Molecular and therapeutic landscape of ferroptosis in skin diseases

Le,

Meng,

Wang

et al. 2024

Chinese Medical Journal

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Bioactive polysaccharides mediate ferroptosis to modulate tumor immunotherapy

Lin,

Zhou,

Zeng

et al. 2024

International Journal of Biological Macromolecules

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Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

Zeng,

Yang,

et al. 2024

Cell Death Dis

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Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with immune cells being a crucial component of the body’s immune system. This review provides an overview and discusses the relationship between ferroptosis, programmed cell death in immune cells, and autoimmune diseases. Additionally, it summarizes the role of various key targets of ferroptosis, such as GPX4 and TFR, in immune cell immune responses. Furthermore, the release of multiple molecules, including damage-associated molecular patterns (DAMPs), following cell death by ferroptosis, is examined, as these molecules further influence the differentiation and function of immune cells, thereby affecting the occurrence and progression of autoimmune diseases. Moreover, immune cells secrete immune factors or their metabolites, which also impact the occurrence of ferroptosis in target organs and tissues involved in autoimmune diseases. Iron chelators, chloroquine and its derivatives, antioxidants, chloroquine derivatives, and calreticulin have been demonstrated to be effective in animal studies for certain autoimmune diseases, exerting anti-inflammatory and immunomodulatory effects. Finally, a brief summary and future perspectives on the research of autoimmune diseases are provided, aiming to guide disease treatment strategies.

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Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney

Cited by 3 publications

References 36 publications

Molecular and therapeutic landscape of ferroptosis in skin diseases

Molecular and therapeutic landscape of ferroptosis in skin diseases

Bioactive polysaccharides mediate ferroptosis to modulate tumor immunotherapy

Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases

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