Neutrophil Depletion Changes the N-Glycosylation Pattern of IgG in Experimental Murine Sepsis
Kursat O. Yaykasli,
Karin A. van Schie,
René E. M. Toes
et al.
Abstract:Sepsis is a life-threatening condition with a rising disease burden worldwide. It is a multifactorial disease and is defined as a dysregulated host response to infection. Neutrophils have been shown to be involved in the pathogenesis of sepsis by exacerbating inflammation. However, the exact effector mechanism of action still remains a mystery. Changes in the glycosylation pattern of the immunoglobulin G (IgG) Fc region are described for several diseases including meningococcal sepsis. In this study, we invest… Show more
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