2004
DOI: 10.1016/j.ijcard.2003.06.028
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Neutrophil count and infarct size in patients with acute myocardial infarction

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Cited by 91 publications
(64 citation statements)
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References 12 publications
(5 reference statements)
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“…In contrast to the phagocytic and killing effects of neutrophils, lymphocytes fulfill the regulatory function of the immune system (12,(16)(17)(18). Increased neutrophil count was found to be associated with infarct size and adverse angiographic outcomes in patients with myocardial infarction (12,19,20), while low lymphocyte count was related to adverse outcomes in patients with myocardial infarction and chronic heart failure (12,21,22). Since NLR reflects both immune pathways and is probably less affected by confounding conditions, it may be more predictive than either parameter alone (12).…”
Section: Discussionmentioning
confidence: 99%
“…In contrast to the phagocytic and killing effects of neutrophils, lymphocytes fulfill the regulatory function of the immune system (12,(16)(17)(18). Increased neutrophil count was found to be associated with infarct size and adverse angiographic outcomes in patients with myocardial infarction (12,19,20), while low lymphocyte count was related to adverse outcomes in patients with myocardial infarction and chronic heart failure (12,21,22). Since NLR reflects both immune pathways and is probably less affected by confounding conditions, it may be more predictive than either parameter alone (12).…”
Section: Discussionmentioning
confidence: 99%
“…[14][15][16] In addition, increased neutrophil-platelet aggregates could be seen in microcirculation, leading to the no-reflow phenomenon, larger infarct size, and poor prognosis. [17][18][19] In acute conditions, lymphopenia, especially low CD4þ during stress response, is another common finding, and it is associated with poorer prognosis after STEMI. 20 Regulatory CD4þ T cells have decreased response to increased oxidized low-density lipoprotein and cortisol secretions.…”
Section: Discussionmentioning
confidence: 99%
“…[3][4][5] An increased neutrophil count reflects ongoing inflammation, whereas a low lymphocyte count reflects malnutrition and inflammatory status. 6,7 The neutrophil-to-lymphocyte ratio, by integrating the deleterious effects of neutrophilia and lymphopenia, is now recognised as a systemic inflammatory marker. 8 Measuring the neutrophil-tolymphocyte ratio is an inexpensive, readily available and reproducible testing method.…”
Section: Introductionmentioning
confidence: 99%