Neutrophil Chemotaxis in Patients With Acne Receiving Oral Tetracycline Therapy

Esterly, Nancy B.; Koransky, Joel S.; Furey, Nancy; Trevisan, Maurizio

doi:10.1001/archderm.1984.01650460048018

Cited by 93 publications

(23 citation statements)

References 17 publications

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“…As tetracyclines, including minocycline, have been reported to reduce neutrophil chemotaxis (Esterly et al, 1978;1984), different studies have evaluated their effectiveness in cutaneous inflammation. Ishikawa et al (2009) reported that minocycline, at concentrations similar to those obtained therapeutically in serum (5 or 10 mM) (Agwuh and MacGowan, 2006), reduced the protease-activated receptor 2-mediated production of IL-8, and thus attenuated the proinflammatory process in epidermal keratinocytes.…”

Section: Effects Of Minocycline On Dermatitismentioning

confidence: 99%

Minocycline: far beyond an antibiotic

Garrido-Mesa

Zarzuelo

Gálvez

2013

British J Pharmacology

763

597

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Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic use for over 30 years because of its antibiotic properties against both gram‐positive and gram‐negative bacteria. It is mainly used in the treatment of acne vulgaris and some sexually transmitted diseases. Recently, it has been reported that tetracyclines can exert a variety of biological actions that are independent of their anti‐microbial activity, including anti‐inflammatory and anti‐apoptotic activities, and inhibition of proteolysis, angiogenesis and tumour metastasis. These findings specifically concern to minocycline as it has recently been found to have multiple non‐antibiotic biological effects that are beneficial in experimental models of various diseases with an inflammatory basis, including dermatitis, periodontitis, atherosclerosis and autoimmune disorders such as rheumatoid arthritis and inflammatory bowel disease. Of note, minocycline has also emerged as the most effective tetracycline derivative at providing neuroprotection. This effect has been confirmed in experimental models of ischaemia, traumatic brain injury and neuropathic pain, and of several neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease, multiple sclerosis and spinal cord injury. Moreover, other pre‐clinical studies have shown its ability to inhibit malignant cell growth and activation and replication of human immunodeficiency virus, and to prevent bone resorption. Considering the above‐mentioned findings, this review will cover the most important topics in the pharmacology of minocycline to date, supporting its evaluation as a new therapeutic approach for many of the diseases described herein.

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Section: Effects Of Minocycline On Dermatitismentioning

confidence: 99%

Minocycline: far beyond an antibiotic

Garrido-Mesa

Zarzuelo

Gálvez

2013

British J Pharmacology

763

597

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“…They are effective in acne both by inhibiting bacterial protein synthesis 38 and by decreasing inflammation via inhibition of bacterial proinflammatory mediators and decreasing neutrophil chemotaxis. 58,59 The alarming increase in P acnes resistance to both topical and systemic antibiotics used to treat acne not only renders these drugs less effective against acne but may also influence commensal bacteria in both the acne patient and his or her environment. 60 Resistance may occur with both appropriate and incorrect use of antibiotics.…”

Section: Antibiotics/antimicrobialsmentioning

confidence: 99%

Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne

et al. 2013

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INTRODUCTION: Acne vulgaris is one of the most common skin conditions in children and adolescents. The presentation, differential diagnosis, and association of acne with systemic pathology differs by age of presentation. Current acknowledged guidelines for the diagnosis and management of pediatric acne are lacking, and there are variations in management across the spectrum of primary and specialty care. The American Acne and Rosacea Society convened a panel of pediatric dermatologists, pediatricians, and dermatologists with expertise in acne to develop recommendations for the management of pediatric acne and evidence-based treatment algorithms. METHODS: Ten major topic areas in the diagnosis and treatment of pediatric acne were identified. A thorough literature search was performed and articles identified, reviewed, and assessed for evidence grading. Each topic area was assigned to 2 expert reviewers who developed and presented summaries and recommendations for critique and editing. Furthermore, the Strength of Recommendation Taxonomy, including ratings for the strength of recommendation for a body of evidence, was used throughout for the consensus recommendations for the evaluation and management of pediatric acne. Practical evidence-based treatment algorithms also were developed. RESULTS: Recommendations were put forth regarding the classification, diagnosis, evaluation, and management of pediatric acne, based on age and pubertal status. Treatment considerations include the use of over-the-counter products, topical benzoyl peroxide, topical retinoids, topical antibiotics, oral antibiotics, hormonal therapy, and isotretinoin. Simplified treatment algorithms and recommendations are presented in detail for adolescent, preadolescent, infantile, and neonatal acne. Other considerations, including psychosocial effects of acne, adherence to treatment regimens, and the role of diet and acne, also are discussed. CONCLUSIONS: These expert recommendations by the American Acne and Rosacea Society as reviewed and endorsed by the American Academy of Pediatrics constitute the first detailed, evidence-based clinical guidelines for the management of pediatric acne including issues of special concern when treating pediatric patients.

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“…One mechanism by which this drug exerts its effect is by inhibiting the proliferation of Propionibacterium acnes. However, the lack of correlation between the drug dose regimen and cutaneous bacterial counts has led to speculation that this drug also interferes with the inflammatory reaction (86).…”

Section: Immunodepression and Anti-inflammatory Activity Of Antibactementioning

confidence: 99%