Neutrophil CD64 molecule expression can predict bloodstream infection in septic shock patients

Rogina, Petra; Stubljar, David; Zupanc, Tatjana Lejko; Ihan, Alojz; Skvarč, Miha

doi:10.1515/cclm-2016-0776

Cited by 3 publications

(2 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can be seen from both of them that CD64 can be used as an effective index for early diagnosis of adult bacterial pneumonia. This is consistent with the results of literature [21,22]. According to the analysis of multiple linear regression model, it is the best choice to comprehensively use PCT, CRP, CD64, N/L and N% as the comprehensive indicators in the differential diagnosis of adult bacterial pneumonia.…”

Section: Discussionsupporting

confidence: 90%

Utility of PCT, CRP, CD64, N/L and N% in Diagnosis of Bacterial Pneumonia in Adults: Based on the Data of 199 Bacterial Pneumonia

Jin¹,

Nanzhen²,

Haihua³

et al. 2021

IJIDT

View full text Add to dashboard Cite

In the background of inefficient indicators for early diagnosis of pneumonia in adults, Objective Explore the utility of PCT, CRP, CD64 and Routine Blood Parameter in diagnosis of bacterial pneumonia in adults. Methods From January 1, 2019 to December 31, 2019, 191 adult bacterial pneumonia patients diagnosed and treated in the affiliated Hospital of Inner Mongolia University for Nationalities and 99 healthy people were selected as study subjects. A total of 191 adult bacterial pneumonia patients were treated as the case group, and 99 healthy physical examination patients were treated as the control group. PCT, CRP, CD64 and blood routine test parameters were compared between them. Correlation analysis and multiple linear regression analysis were used to explore the differential factors of adult bacterial pneumonia, and ROC curve was used to analyze the effectiveness of each indicator in the differential diagnosis of adult bacterial pneumonia. Results PCT (4.95±2.462), CRP (33.53±9.342), CD64 (9.26±4.023), N/L (9.54±3.878) and N% (1.16±0.632) in the case group were significantly higher than (0.22±0.059), (3.29±1.712), (1.91±0.600), (2.66±0.665) and (0.66±0.158), those of the control group. There were no statistically significant differences in other indicators.

show abstract

Section: Discussionsupporting

confidence: 90%

Utility of PCT, CRP, CD64, N/L and N% in Diagnosis of Bacterial Pneumonia in Adults: Based on the Data of 199 Bacterial Pneumonia

Jin¹,

Nanzhen²,

Haihua³

et al. 2021

IJIDT

View full text Add to dashboard Cite

show abstract

“…2A). It has been demonstrated that the neutrophil CD64 index had higher diagnostic value for bacterial infection and was positively correlated with illness severity during sepsis (15). The neutrophil CD64 index was significantly increased in patients with overt DIC relative to the other groups (Fig.…”

Section: Resultsmentioning

confidence: 99%

Immunosuppression Correlates With the Deterioration of Sepsis-Induced Disseminated Intravascular Coagulation

Sun

Feng

et al. 2024

Shock

View full text Add to dashboard Cite

Background: The dysregulated host responses play a crucial role in the pathophysiology process of sepsis-induced disseminated intravascular coagulation (DIC). The study aimed to characterize the dynamic alternation of immune-related biomarkers and their relationship with the progression of DIC during sepsis. Methods: A prospective, observational study was conducted in a tertiary care academic hospital. Six hundred forty patients with sepsis were classified into three groups according to the International Society on Thrombosis and Hemostasis (ISTH) score: 383 involved patients without DIC (ISTH = 0), 168 sepsis with nonovert DIC (ISTH = 1-4), and 89 sepsis with overt DIC (ISTH ≥5). Eighteen immune-related biomarkers and six routine coagulation variables were examined at D1, D3, and D7 upon enrollment. The association between the immune parameters and the DIC deterioration was assessed during sepsis. Results: The study showed a 40% coagulation disorder and a 14% incidence of overt DIC in patients with sepsis. The patients with overt DIC displayed pronounced immune disorders from D1 to D7 upon sepsis, which was characterized by the decreased percentage of monocyte HLA-DR (mHLA-DR), increased percentage of regulatory T cells, the levels of procalcitonin, neutrophil CD64 index, and systemic inflammatory cytokines relative to nonovert DIC or non-DIC patients. In multivariate analysis, the combination of anti-inflammatory cytokine IL-10 and mHLA-DR at D1 upon enrollment had a superior predictive value for predicting DIC deterioration in sepsis (area under the curve = 0.87, P < 0.0001). Conclusion: These data illustrate that immunosuppression can crosstalk with coagulation disorder during sepsis and present an additional evaluation tool to predict DIC deterioration.

show abstract

Accuracy of CD64 expression on neutrophils and monocytes in bacterial infection diagnosis at pediatric intensive care admission

García-Salido

Azagra-Garde

Teresa

et al. 2019

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Neutrophil CD64 molecule expression can predict bloodstream infection in septic shock patients

Cited by 3 publications

References 10 publications

Utility of PCT, CRP, CD64, N/L and N% in Diagnosis of Bacterial Pneumonia in Adults: Based on the Data of 199 Bacterial Pneumonia

Utility of PCT, CRP, CD64, N/L and N% in Diagnosis of Bacterial Pneumonia in Adults: Based on the Data of 199 Bacterial Pneumonia

Immunosuppression Correlates With the Deterioration of Sepsis-Induced Disseminated Intravascular Coagulation

Accuracy of CD64 expression on neutrophils and monocytes in bacterial infection diagnosis at pediatric intensive care admission

Contact Info

Product

Resources

About