Neutrophil Alkaline Phosphatase in AIDS

Grozdea, J.; A, Brisson-Lougarre; Vergnes, Hugues; BIum, C.; Alie-Daram, S; Martirn, J.; Biermé, R

doi:10.1159/000205650

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, Grozdea et al (92) reported in a 22-year-old pregnant woman with AIDS a markedly decreased level of neutrophil alkaline phosphatase. Low levels of this enzyme is another marker of precursor PMN. Although this finding was demonstrated in only one patient, it was associated with a poor long-term prognosis.…”

Section: Possible Mechanismsmentioning

confidence: 75%

Role of Polymorphonuclear Leukocytes in Infection by Retroviruses with Emphasis on the Human Immunodeficiency Virus

Mertins¹,

Ortona²,

Cauda³

1990

Viral Immunology

View full text Add to dashboard Cite

Neutrophil function is an integral part of the host defense against multiple pathogens. Through phagocytosis and production of toxic substances, these short lived cells aid in the effective elimination of invading microorganisms such as bacterial and fungal targets. Viral infections, and in particular those of the retroviral type, appear to suppress the immune response through direct cytotoxic destruction of immune cells or alteration of the biochemical interactions that are essential for eradicating the foreign agent. In this report, we describe abnormalities of neutrophil number and function consequent to HIV and other retroviral infections. A myriad of mechanisms, either alone or in concert may explain the underlying aberrations.

show abstract

Section: Possible Mechanismsmentioning

confidence: 75%

Role of Polymorphonuclear Leukocytes in Infection by Retroviruses with Emphasis on the Human Immunodeficiency Virus

Mertins¹,

Ortona²,

Cauda³

1990

Viral Immunology

View full text Add to dashboard Cite

show abstract

“…With this approach we rapidly purified neutrophil APase to homogeneity: this protein was then used for immunization. Immunoblotting, ELISA, and immunocytochemical localization were used to paroxsymal nocturnal hemoglobinuria, and acquired immune deficiency (5, 12,15).…”

Section: Introductionmentioning

confidence: 99%

Rapid purification of glycosyl-phosphatidylinositol-anchored alkaline phosphatase from human neutrophils after up-regulation to the cell surface.

Cain

Liu²,

Kobayashi³

et al. 1993

J Histochem Cytochem.

View full text Add to dashboard Cite

P r i n t d m lIS.A. Original Article IAlkaline phosphatase (APase) belongs to a growing family of membrane-associated proteins tethered to the lipid bilayer via a glycosyl-phosphatidylinositol (GPI) anchor. Human neutrophils contain an intracellular pool of APase associated with a novel membrane-bound compartment. Stimulation of neutrophils with the chemotactic peptide formyl-Met-LeuPhe (fMLP) leads to rapid up-regulation of essentially all of the APase to sites in continuity with the smacellular medium. Pre-treatment of neutrophils with cytochalasin B (cyto B) followed by fMLp likewise leads to expression of the enzyme on the cell surface and a dramatic alteration in cell morphology, but subsequent internalization of the plasmalemma is minimized. Pre-treatment with cyto B and fMLP has been

show abstract

“…I have read with interest the communication of Grozdea et al [1] on 'Neutrophil alkaline phospha tase in AIDS' in the recent issue of the Journal. I could not be sure whether this patient's neutrophil al kaline phosphatase (NAP) activity was studied in the postpartum period.…”

mentioning

confidence: 99%

About Leukocyte Alkaline Phosphatase

Özsoylu¹

1989

Acta Haematol

View full text Add to dashboard Cite

Neutrophil Alkaline Phosphatase in AIDS

Cited by 5 publications

References 0 publications

Role of Polymorphonuclear Leukocytes in Infection by Retroviruses with Emphasis on the Human Immunodeficiency Virus

Role of Polymorphonuclear Leukocytes in Infection by Retroviruses with Emphasis on the Human Immunodeficiency Virus

Rapid purification of glycosyl-phosphatidylinositol-anchored alkaline phosphatase from human neutrophils after up-regulation to the cell surface.

About Leukocyte Alkaline Phosphatase

Contact Info

Product

Resources

About