Neutrophil activation in pregnancy-induced hypertension

Greer, I. A.; Haddad, NG; Dawes, J.; Johnstone, F. D.; Calder, A. A.

doi:10.1016/0020-7292(90)91069-3

Cited by 49 publications

(60 citation statements)

References 3 publications

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“…The normally observed activation in maternal circulating neutrophils in pregnancy is more marked in patients with PE (15)(16)(17) , probably due to elevated plasma levels of arachidonic acid in preeclamptic women (18,19) . In our study, neutrophil count was also higher among patients with PE than among controls.…”

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Akıl¹

2015

Kosuyolu Heart Journal

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Introduction: This study was undertaken to examine the role of hematological parameters in predicting the severity of hypertension in pre-eclamptic women. Patients and Methods:Two hundred sixty-one pre-eclamptic women and fi fty-one women with normal pregnancy were included in the study. The severity of preeclampsia was classifi ed as mild or severe.Results: Compared to post-delivery period, pre-eclamptic females had lower platelet count, raised mean platelet volume and raised neutrophil lymphocyte ratio (p< 0.001, p< 0.001, p< 0.001, respectively). Multiple linear regression analysis showed an independent correlation between the severity of hypertension and mean platelet volume as well as the neutrophil lymphocyte ratio (β= 0.25, p< 0.001; β= 0.31, p< 0.001, respectively). Conclusion:Both mean platelet volume and neutrophil lymphocyte ratio emerged as independent predictors of the severity of hypertension in preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Akıl¹

2015

Kosuyolu Heart Journal

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“…Consequently, we propose the hypothesis that leakage of fluids and proteins could result in edema and proteinuria, conditions observed in women with preeclampsia. 41,42 The maternal vascular system undergoes an inflammatory process during preeclampsia, as evidenced by increased neutrophil activation [43][44][45][46] and vascular neutrophil infiltration. 6 -8 In the early phase of this study, we hypothesized that infiltrating neutrophils could affect expression of genes related to the extracellular matrix.…”

Section: Discussionmentioning

confidence: 99%

Increased Expression of Matrix Metalloproteinase-1 in Systemic Vessels of Preeclamptic Women

Estrada-Gutiérrez

Cappello

Mishra

et al. 2011

The American Journal of Pathology

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This study was conducted to determine the following: (1) whether matrix metalloproteinase-1 (MMP-1) is increased in systemic vessels of preeclamptic women, (2) whether this increase might be mediated by neutrophils, and (3) whether MMP-1 could be responsible for vascular dysfunction. Omental arteries and plasma were collected from healthy pregnant and preeclamptic women. Omental arteries were evaluated for gene and protein expression of MMP-1, collagen type 1␣, tissue inhibitor of metalloproteinase-1, and vascular reactivity to MMP-1. Gene and protein expression levels were also evaluated in human vascular smooth muscle cells (VSMCs) co-cultured with activated neutrophils, reactive oxygen species, or tumor necrosis factor ␣. Vessel expression of MMP-1 and circulating MMP-1 levels were increased in preeclamptic women, whereas vascular expression of collagen or tissue inhibitor of metalloproteinase-1 were down-regulated or unchanged. In cultured VSMCs, the imbalance in collagen-regulating genes of preeclamptic vessels was reproduced by treatment with neutrophils, tumor necrosis factor ␣, or reactive oxygen species. Chemotaxis studies with cultured cells revealed that MMP-1 promoted recruitment of neutrophils via vascular smooth muscle release of interleukin-8. Furthermore, MMP-1 induced vasoconstriction via protease-activated receptor-1, whose expression was significantly increased in omental arteries of preeclamptic women and in VSMCs co-cultured with neutrophils. Collectively, these findings disclose a novel role for MMP-1 as a mediator of vasoconstriction and vascular dysfunction in preeclampsia.

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“…Phagocytes (granulocytes and monocytes) produce and secrete reactive oxygen species as a nonspecific immune defense mechanism [8,9]. An abnormally activated clotting system and an affected complement system have been revealed [10], as has an increased release of the proinflammatory cytokines and fibronectin degradation products into the circulation [11].…”

Section: Introductionmentioning

confidence: 99%

Blood glutathione redox status in gestational hypertension

Németh

Orvos

Boda

2001

Free Radical Biology and Medicine

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Abstract-Gestational hypertension during the third trimester reflects an exaggerated maternal inflammatory response to pregnancy. We hypothesized that oxidative stress present even in normal pregnancy becomes uncompensated in hypertensive patients. A glucose-6-phosphate dehydrogenase (G6PD) activity sufficient to meet the increased reductive equivalent need of the cells is indispensable for defense against oxidative stress. The erythrocyte glutathione redox system was studied, where G6PD is the only NADPH source. The glutathione (GSH) redox status was measured both in vivo and after an in vitro oxidative challenge in pregnant women with gestational hypertension (n ϭ 19) vs. normotensive pregnant subjects (n ϭ 18) and controls (n ϭ 20). An erythrocyte GSH depletion with an increase in the oxidized form (GSSG) resulted in an elevated ratio GSSG/GSH (0.305 Ϯ 0.057; mean Ϯ SD) in hypertensive pregnant women vs. normotensive pregnant or control subjects (0.154 Ϯ 0.025; 0.168 Ϯ 0.073; p Ͻ .001). In hypertensive pregnant patients, a "GSH stability" decrease after an in vitro oxidative challenge suggested a reduced GSH recycling capacity resulting from an insufficient NADPH supply. The erythrocyte GSSG/GSH ratio may serve as an early and sensitive parameter of the oxidative imbalance and a relevant target for future clinical trials to control the effects of antioxidant treatment in women at increased risk of the pre-eclampsia syndrome.

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Neutrophil activation in pregnancy-induced hypertension

Cited by 49 publications

References 3 publications

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Mean Platelet Volume and Neutrophil Lymphocyte Ratio as New Markers of Preeclampsia Severity

Increased Expression of Matrix Metalloproteinase-1 in Systemic Vessels of Preeclamptic Women

Blood glutathione redox status in gestational hypertension

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