Neutrophil-activating secretome characterizes palbociclib-induced senescence of breast cancer cells
Gabriele Favaretto,
Marianna Nicoletta Rossi,
Lorenzo Cuollo
et al.
Abstract:Senescent cells have a profound impact on the surrounding microenvironment through the secretion of numerous bioactive molecules and inflammatory factors. The induction of therapy-induced senescence by anticancer drugs is known, but how senescent tumor cells influence the tumor immune landscape, particularly neutrophil activity, is still unclear. In this study, we investigate the induction of cellular senescence in breast cancer cells and the subsequent immunomodulatory effects on neutrophils using the CDK4/6 … Show more
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