Neutrophil-activating protein in Bacillus spores inhibits casein allergy via TLR2 signaling
zhenwen zhou,
Zhuwei Liang,
Chao Zhang
et al.
Abstract:Background: Milk allergy commonly occurs in children, mainly
caused by casein (CAS) protein. Neutrophil-activating protein (NAP) of
Helicobacter pylori plays an immunomodulatory role with potential
to suppress Th2-type immune responses. Bacillus subtilis spores
are commonly used as oral vectors for drug delivery. We hypothesized
that recombinantly expressed NAP on B. subtilis spores could be
an effective treatment for CAS allergy. Methods: After CAS
sensitization, mice were orally administered B. subtilis spor… Show more
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