Neutropenia Following Amidopyrine

Hoffman, Arthur; Butt, E. M.; Hickey, Nikita

doi:10.1001/jama.1934.02750150017005

Cited by 46 publications

(4 citation statements)

References 2 publications

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“…Agranulocytosis and neutropaenia have been associated with the therapeutic use of DNP [36,37,45,47,[58][59][60][61]. Cataracts can develop quickly after the use of DNP, usually leading to a permanent decrease in vision to light-dark perception in days to months [62][63][64][65].…”

Section: Organ Systems Affected By Therapeutic Usementioning

confidence: 99%

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

2011

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2,4-Dinitrophenol (DNP) is reported to cause rapid loss of weight, but unfortunately is associated with an unacceptably high rate of significant adverse effects. DNP is sold mostly over the internet under a number of different names as a weight loss/slimming aid. It causes uncoupling of oxidative phosphorylation; the classic symptom complex associated with toxicity of phenol-based products such as DNP is a combination of hyperthermia, tachycardia, diaphoresis and tachypnoea, eventually leading to death. Fatalities related to exposure to DNP have been reported since the turn of the twentieth century. To date, there have been 62 published deaths in the medical literature attributed to DNP. In this review, we will describe the pattern and pathophysiology of DNP toxicity and summarise the previous fatalities associated with exposure to DNP.

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Section: Organ Systems Affected By Therapeutic Usementioning

confidence: 99%

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

2011

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“…As a result, TPHP and DPHP have been found within indoor dust, as both TPHP and DPHP are additive FRs that, similar to PBDEs, migrate out of end-use products into surrounding environmental media. 6 TPHP and DPHP have been detected within human samples, 7,8 including urine of pregnant women 9 and infants, [10][11][12] underscoring the need for generation of developmental toxicity data. Interestingly, higher concentrations of DPHP have been detected in urine samples collected from women, a finding that is strongly associated with altered total thyroxine levels 13 and TPHP-induced disruption of thyroid function within animal-and cell-based systems.…”

Section: Introductionmentioning

confidence: 99%

Diphenyl Phosphate-Induced Toxicity During Embryonic Development

Mitchell

Reddam

Dasgupta

et al. 2019

Environ. Sci. Technol.

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Diphenyl phosphate (DPHP) is an aryl phosphate ester (APE) used as an industrial catalyst and chemical additive and is the primary metabolite of flame retardant APEs, including triphenyl phosphate (TPHP). Minimal DPHP-specific toxicity studies have been published despite ubiquitous exposure within human populations following metabolism of TPHP and other APEs. Therefore, the objective of this study was to determine the potential for DPHP-induced toxicity during embryonic development. Using zebrafish as a model, we found that DPHP significantly increased the distance between the sinus venosus and bulbus arteriosis (SV-BA) at 72 h postfertilization (hpf) following initiation of exposure before and after cardiac looping. Interestingly, pretreatment with D-mannitol mitigated DPHP-induced effects on SV-BA length despite the absence of DPHP effects on pericardial area, suggesting that DPHP-induced cardiac defects are independent of pericardial edema formation. Using mRNA-sequencing, we found that DPHP disrupts pathways related to mitochondrial function and heme biosynthesis; indeed, DPHP significantly decreased hemoglobin levels in situ at 72 hpf following exposure from 24 to 72 hpf. Overall, our findings suggest that, similar to TPHP, DPHP impacts cardiac development, albeit the potency of DPHP is significantly less than TPHP within developing zebrafish.

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“…Their observations have been confirmed by Watkins,435 Randall,436 Hoffman and his associates, 437 Sturgis and Isaacs 438 and others. The fact that a person ingests a certain drug immediately before the onset of a disease is suggestive but not conclusive evidence that it is the cause of the condition.…”

Section: Hemophiliamentioning

confidence: 79%

Blood

Sturgis¹

1935

Arch Intern Med (Chic)

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Neutropenia Following Amidopyrine

Cited by 46 publications

References 2 publications

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

Diphenyl Phosphate-Induced Toxicity During Embryonic Development

Blood

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