Neutron therapy for malignant tumours of the salivary glands. A report of the edinburgh experience

Duncan, W.; Orr, J.A.; Arnott, S.J.; Jack, W

doi:10.1016/s0167-8140(87)80162-7

Cited by 40 publications

(8 citation statements)

References 14 publications

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“…11 Over the past 15 years, retrospective studies and a single prospective randomized trial have shown an advantage in local-regional control with the use of "high linear energy transfer (LET)" neutron radiotherapy compared with photons (low LET). [12][13][14][15][16][17][18] This report updates our experience treating salivary gland neoplasms with fast neutron radiotherapy.…”

Section: Arch Otolaryngol Head Neckmentioning

confidence: 83%

Treatment of Salivary Gland Neoplasms With Fast Neutron Radiotherapy

Douglas

Koh

Austin-Seymour

et al. 2003

Arch Otolaryngol Head Neck Surg

125

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Section: Arch Otolaryngol Head Neckmentioning

confidence: 83%

Treatment of Salivary Gland Neoplasms With Fast Neutron Radiotherapy

Douglas

Koh

Austin-Seymour

et al. 2003

Arch Otolaryngol Head Neck Surg

125

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“…NRT appears to be more effective than photon irradiation for patients having gross residual disease after surgical resections or biopsies only. [2][3][4][5][6][7][11][12][13][14][15] In our analysis of factors affecting prognosis for this group of patients, we discovered that size > 4 cm, previous irradiation, and base of skull invasion were portenders of poor local control. 8 If surgical resection is possible to reduce the burden of disease, we currently recommend that approach, however, as is often the case with tumors invading the base of skull, and surgical resection is avoided because of the potential for significant facial disfigurement.…”

Section: Discussionmentioning

confidence: 99%

Gamma knife stereotactic radiosurgery for salivary gland neoplasms with base of skull invasion following neutron radiotherapy

2007

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Patients with primary salivary gland neoplasms that involve the base of skull and are treated with neutron radiotherapy alone are at high risk of local recurrence. A gamma knife boost improves local control and adds little additional toxicity. These preliminary results suggest that all patients with salivary neoplasms and base of skull invasion should be considered for a gamma knife boost after primary treatment with neutron radiotherapy.

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“…Moreover, there is no evidence that radiation therapy hinders recovery of function in those patients who have nerve grafts. Preliminary reports suggest that neutron beam irradiation may be more effective than photons or electrons in the treatment of salivary gland carcinoma [17,18].…”

Section: Treatmentmentioning

confidence: 99%

Diagnosis and pitfalls in the treatment of parotid tumors

Spiro¹

1991

Seminars in Surgical Oncology

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Any swelling near the ear is best considered a parotid neoplasm until proved otherwise. The diagnosis is primarily based on the clinical examination. Imaging studies are best reserved for patients who present with palate or tonsil swellings, which must be distinguished from parapharyngeal or minor salivary gland tumors. Almost all benign, and most malignant parotid tumors can be resected with preservation of the facial nerve. Aspiration biopsy can add useful information, but is not essential for treatment planning as the extent of the surgical procedure is primarily determined by the extent of the tumor. Survival rates in patients with malignant tumors are most significantly influenced by tumor stage. Results seem to have improved in recent years, possibly because we are treating a larger proportion with favorable lesions. Another factor may relate to the enhancement of locoregional control now achieved with postoperative radiotherapy, particularly in patients with Stage III or IV tumors.

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Neutron therapy for malignant tumours of the salivary glands. A report of the edinburgh experience

Cited by 40 publications

References 14 publications

Treatment of Salivary Gland Neoplasms With Fast Neutron Radiotherapy

Treatment of Salivary Gland Neoplasms With Fast Neutron Radiotherapy

Gamma knife stereotactic radiosurgery for salivary gland neoplasms with base of skull invasion following neutron radiotherapy

Diagnosis and pitfalls in the treatment of parotid tumors

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