The acceleration of hydrogen ions up to 35 MeV is observed in the z-pinch experiments on the GIT-12 generator at a 3 MA current and 0.6 MV driving voltage. High ion energies are obtained with a novel configuration of a deuterium gas-puff z-pinch. In this configuration, a hollow cylindrical plasma shell is injected around an inner deuterium gas puff to form a homogeneous, uniformly conducting layer between electrodes at the initial phase of z-pinch implosion. The stable implosion at the velocity up to 650 km s −1 is important to deliver more current onto the z-pinch axis. Magnetohydrodynamic instabilities become apparent first at stagnation. After the disruptive development of m=0 instabilities, ∼20 ns pulses of high-energy photons, neutrons, electrons, and ions are observed. The average neutron yield is 2×10 12 . The ion emission is characterized by various diagnostic techniques including those based on the usage of neutronproducing samples. When a large neutron-producing sample is placed onto the axis below a cathode mesh, the neutron yield is increased up to (1.1±0.3)×10 13 . Considering a ∼130 kJ energy input into z-pinch plasmas and magnetic field, this implies the neutron production efficiency of ∼10 8 neutrons per one Joule of the z-pinch energy.