Level density models have increasing importance to gain more in-depth into the nature of nuclear reactions. Many novel and advanced medical application use radioisotopes, which are produced with nuclear reactions. In this study, the effect of the level density parameters of the nucleus on the cross sections of neutron-fission reactions for 233U, 235U, 237U, 239U, 249Cf, 251Cf, 237Pu and 247Cm nuclei were investigated for up to 20 MeV neutrons. TALYS 1.8 software was used to calculate the cross-sections of neutron-fission reactions for different level density parameters. The calculations were compared with the EXFOR nuclear data library and the level density parameters, and the closest fit were searched. As outputs of the study, the effect of selection of level density parameter on cross section calculations was observed. The theoretically obtained data were compared with the experimental data taken from the literature. The results are presented graphically for better interpretation.