Neutron-activation analysis of trace elements in thyroids

Boulyga, Sergei F.; Petri, H.; Zhuk, I.V.; Kanash, N. V.; Malenchenko, A.F.

doi:10.1007/bf02345561

Cited by 4 publications

(2 citation statements)

References 1 publication

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“…The ratios of means and the comparison of mean values of Ag, Co, Cr, Fe, Hg, I, Rb, Sb, Sc, Se, and Zn mass fractions in pair of sample groups such as NT and TBN, NT and TMN, and also TBN and TMN is presented in Table 2. The comparison of our results with published data (from 1990 year) for I mass fraction in NT [27,28,[31][32][33][34]37,[53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72], TBN [54,56,57,62,63,[67][68][69][70][71][72][73][74][75][76][77][78][79][80], and TMN [54,56,…”

Section: Resultsmentioning

confidence: 57%

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Zaichick¹

2022

World J. Adv. Res. Rev.

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Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in trace elements (TEs) contents in nodular tissue for diagnosis of thyroid malignancy. Contents of TEs such as silver (Ag), cobalt (Co), chromium (Cr), iron (Fe), mercury (Hg), iodine (I), rubidium (Rb), antimony (Sb), scandium (Sc), selenium (Se), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using non-destructive instrumental neutron activation analysis. It was observed that in TMN tissue the mean mass fraction of I was lower while the mean mass fraction of Rb was higher than in NT and TBN tissue. It was demonstrated that I content in nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue was significantly higher than that using US examination and cytological test of fine needle aspiration biopsy. It was concluded that determination of the I level in a needle biopsy of TNs using non-destructive instrumental analytical method is a fast, reliable, and very informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification.

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Section: Resultsmentioning

confidence: 57%

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Zaichick¹

2022

World J. Adv. Res. Rev.

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“…Table-1 depicts certain statistical parameters (arithmetic mean, standard deviation, standard error of mean, range) of the Al, B, Ba, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V, and Zn mass fraction in thyroid tissue samples of three groups -NT, TBN The ratios of means and the comparison of mean values of Al, B, Ba, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V, and Zn mass fractions in pair of sample groups such as NT and TBN, NT and TMN, and also TBN and TMN is presented in Table -2 The comparison of our results with published data (from 1990 year) for I mass fraction in NT [27,28,[31][32][33][34]37,[53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72], TBN [54,56,57,62,63,[67][68][69][70][71][72][73][74][75][76][77][78]…”

Section: Resultsmentioning

confidence: 91%

Diagnosis of Thyroid Malignancy using Levels of Chemical Element Contents in Nodular Tissue

Zaichick

2022

J Health Care and Research

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Introduction: Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in chemical elements (ChEs) contents in nodular tissue for diagnosis of thyroid malignancy. Methods: Contents of ChEs such as aluminum (Al), boron (B), barium (Ba), calcium (Ca), chlorine (Cl), coper (Cu), iron (Fe), iodine (I), potassium (K), lithium (Li), magnesium (Mg), manganese (Mn), sodium (Na), phosphorus (P), sulfur (S), silicon (Si), strontium (Sr), vanadium (V), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides and inductively coupled plasma atomic emission spectrometry. Results: It was observed that in TMN tissue the mean mass fraction of I was lower while the mean mass fractions of K, Mg, and P were higher than in both NT and TBN groups of samples. It was demonstrated that I content is nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue was significantly higher than that using US examination and cytological test of fine needle aspiration biopsy. Conclusions: It was concluded that determination of the I level in a needle biopsy of TNs using non-destructive instrumental analytical method is a fast, reliable, and very informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification.

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Application of SEC-ICP-MS for comparative analyses of metal-containing species in cancerous and healthy human thyroid samples

et al. 2004

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Size exclusion chromatography (SEC) was coupled on-line to inductively coupled plasma mass spectrometry (ICP-MS) for speciation study of trace metals in cancerous thyroid tissues in comparison to healthy thyroids aimed to estimation of changes in metalloprotein speciation in pathological tissue. The study showed a presence of species binding Cu, Zn, Cd and Pb in healthy thyroid tissue with a good reproducibility of chromatographic results, whereas the same species could not be detected in cancerous tissues. Thus, remarkable differences with respect to metal-binding species were revealed between healthy and pathological thyroid samples, pointing out a completely different distribution of trace metals in cancerous tissues. The metal-binding species could not be identified in the frame of this work because of a lack of appropriate standards. Nevertheless, the results obtained confirm the suitability of SEC-ICP-MS for monitoring of changes in trace metal distribution in cancerous tissue and will help to better understand the role of metal-containing species in thyroid pathology.

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Neutron-activation analysis of trace elements in thyroids

Cited by 4 publications

References 1 publication

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Diagnosis of thyroid malignancy using trace elements of nodular tissue determined by neutron activation analysis

Diagnosis of Thyroid Malignancy using Levels of Chemical Element Contents in Nodular Tissue

Application of SEC-ICP-MS for comparative analyses of metal-containing species in cancerous and healthy human thyroid samples

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