Neutron Activation Analysis of Arsenic in Normal Skin, Keratoses, and Epitheliomas

Domonkos, Anthony N.

doi:10.1001/archderm.1959.01560240024003

Cited by 19 publications

(2 citation statements)

References 5 publications

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“…Characteristically, the natural history is long in extramammary Paget's disease and 5, 10 or 15 years may elapse without any evidence of cancer, but in occasional cases malignancy seems to be present almost from the onset. The disease affects mainly older people and the incidence in women is more than twice that in men (Helwig & Graham 1963, Domonkos 1959.…”

Section: Discussionmentioning

confidence: 99%

Paget's Disease of Perianal Skin

1968

Proceedings of the Royal Society of Medicine

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Section: Discussionmentioning

confidence: 99%

Paget's Disease of Perianal Skin

1968

Proceedings of the Royal Society of Medicine

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“…Clinical experience argued for the possibility that arsenic works as a carcinogen primarily in pathologically altered terrain-skin hyperkeraroses, cirrhotic liver, (vineyards) chronic bronchitis from industrial irritants, and so on. Nevertheless, activation analysis of epitheliomas has shown smaller quantities of arsenic in the epitheliomas themselves than in the neighboring healthy skin (36). It is well known, however, that substances with delayed effects, e.g., beryllium, are not present in the affected tissue in important quantities at the time pathological changes manifest themselves.…”

mentioning

confidence: 99%

Carcinogenic, Teratogenic, and Mutagenic Effects of Arsenic

Bencko¹

1977

Environmental Health Perspectives

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This review outlines briefly the history and present status of the problem of carcinogenic, teratogenic and mutagenic effects of arsenic. Discrepancies between dinical observations and positive results of epidemiological studies and the experimental induction of cancer by arsenic are discussed. The present knowledge of the mechanism of teratogenic and mutagenic effects of arsenic is analyzed.The growing importance of arsenic as an environmental pollutant is demonstrated. Continuation of throughly organized epidemiological studies in regions with excessive arsenic exposure of the population and standardization of an epidemiological approach to this problem on an international basis are recommended. New approaches in experimental studies of the carcinogenicity of arsenic in combination with other known or suspected carcinogens are recommended as well.Arsenic has long been thought to contribute to the incidence of cancer. In connection with the growing number of people exposed to this substance, occupationally as well as nonoccupationally in some areas, this becomes an important problem.

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Skin cancer and arsenical intoxication from well water

Wagner¹,

Maliner²,

Morton³

et al. 1979

Archives of Dermatology

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A case of acute arsenical intoxication arising from ingested well water containing only 1.2 ppm of arsenic is reported. After a latent period of 14 years, multiple cutaneous basal cell carcinomas developed. The water was analyzed for a variety of other trace elements and compounds and no evidence for the existence of other carcinogens was found. This study strengthens the concept that arsenic is a carcinogen. The role of a possible selenium deficiency is also discussed.

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Neutron Activation Analysis of Arsenic in Normal Skin, Keratoses, and Epitheliomas

Cited by 19 publications

References 5 publications

Paget's Disease of Perianal Skin

Paget's Disease of Perianal Skin

Carcinogenic, Teratogenic, and Mutagenic Effects of Arsenic

Skin cancer and arsenical intoxication from well water

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