Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters

Borkow, Gadi; Sidwell, Robert W.; Smee, Donald F.; Barnard, Dale L.; Morrey, John D.; Lara, Humberto H; Shemer‐Avni, Yonat; Gabbay, Jeffrey

doi:10.1128/aac.00125-07

Cited by 77 publications

(77 citation statements)

References 7 publications

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“…All the wells exposed to the fourfold sequential dilutions of the eluates from the control filter (Fig. 5a) were positive for HIV-1 infection, with the exception of the last dilution (4 8 ), in which two out of the four wells were positive for HIV-1. Hence, the TCID 50 of the virus that eluted from the control filter was 65,536 per 25 l. In contrast, all the dilutions of the first milliliter collected from the virus filtered through each of the three filter configurations containing copper-impregnated fibers were negative for HIV-1 infection (Fig.…”

Section: Inhibition Of Cell-free Hiv-1 Infectivity By Copper Oxide MIXmentioning

confidence: 99%

“…This technology enabled the production of antibacterial, self-sterilizing fabrics (that kill antibiotic-resistant bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci) and antifungal socks (that alleviate symptoms of athlete's foot) (6,23). Recently we reported the capacity of copper oxide-containing filters to reduce infectious titers of a panel of viruses spiked into culture media, including enveloped and nonenveloped, RNA and DNA viruses, suggesting the possibility of using copper oxide-containing devices to inactivate a wide spectrum of infectious viruses found in filterable suspensions (8). In the present study, we describe the results and development of inexpensive, copper-based filters that inactivate HIV-1 in media.…”

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confidence: 99%

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Deactivation of Human Immunodeficiency Virus Type 1 in Medium by Copper Oxide-Containing Filters

Borkow

Lara

Covington

et al. 2008

Antimicrob Agents Chemother

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Human immunodeficiency virus type 1 (HIV-1) can be transmitted through breast-feeding and through contaminated blood donations. Copper has potent biocidal properties and has been found to inactivate HIV-1 infectivity. The objective of this study was to determine the capacity of copper-based filters to inactivate HIV-1 in culture media. Medium spiked with high titers of HIV-1 was exposed to copper oxide powder or copper oxide-impregnated fibers or passed through copper-based filters, and the infectious viral titers before and after treatment were determined. Cell-free and cell-associated HIV-1 infectivity was inhibited when exposed to copper oxide in a dose-dependent manner, without cytotoxicity at the active antiviral copper concentrations. Similar dose-dependent inhibition occurred when HIV-1 was exposed to copper-impregnated fibers. Filtration of HIV-1 through filters containing the copper powder or copper-impregnated fibers resulted in viral deactivation of all 12 wild-type or drug-resistant laboratory or clinical, macrophage-tropic and T-cell-tropic, clade A, B, or C, HIV-1 isolates tested. Viral inactivation was not strain specific. Thus, a novel means to inactivate HIV-1 in medium has been developed. This inexpensive methodology may significantly reduce HIV-1 transmission from “mother to child” and/or through blood donations if proven to be effective in breast milk or plasma and safe for use. The successful application of this technology may impact HIV-1 transmission, especially in developing countries where HIV-1 is rampant.

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Section: Inhibition Of Cell-free Hiv-1 Infectivity By Copper Oxide MIXmentioning

confidence: 99%

mentioning

confidence: 99%

Deactivation of Human Immunodeficiency Virus Type 1 in Medium by Copper Oxide-Containing Filters

Borkow

Lara

Covington

et al. 2008

Antimicrob Agents Chemother

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“…However, none of these researchers have evaluated these copper nanoparticle membranes as antibacterial drinking water purifiers. A similar membrane technology is a membrane containing copper oxide particles for virus removal from breast milk (Borkow et al, 2007). Recently, a related application using a porous ceramic substrate doped with copper nanoparticles as a filter material showed strong bactericidal activity (Klein et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Incorporation of copper nanoparticles into paper for point-of-use water purification

2014

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As a cost-effective alternative to silver nanoparticles, we have investigated the use of copper nanoparticles in paper filters for point-of-use water purification. This work reports an environmentally benign method for the direct in situ preparation of copper nanoparticles (CuNPs) in paper by reducing sorbed copper ions with ascorbic acid. Copper nanoparticles were quickly formed in less than 10 minutes and were well distributed on the paper fiber surfaces. Paper sheets were characterized by x-ray diffraction, scanning electron microscopy, energy dispersive x-ray spectroscopy, and atomic absorption spectroscopy. Antibacterial activity of the CuNP sheets was assessed for by passing Escherichia coli bacteria suspensions through the papers. The effluent was analyzed for viable bacteria and copper release. The CuNP papers with higher copper content showed a high bacteria reduction of log 8.8 for E. coli. The paper sheets containing copper nanoparticles were effective in inactivating the test bacteria as they passed through the paper. The copper levels released in the effluent water were below the recommended limit for copper in drinking water (1 ppm).

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“…We used copper oxide for two main reasons: (a) copper oxide is a very reactive copper compound with potent biocidal properties, which is being used successfully in many consumer, industrial and medical device products (Borkow andGabbay 2004, 2006;Borkow et al 2007Borkow et al , 2010aBorkow and Monk 2012;Borkow 2012), and (b) copper oxide is a non-soluble copper compound. Obviously in such products, it is important that the active ingredient in the product remains in the product for the life of the product; in this case that it would not be lost into the running water.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of root penetration in subsurface driplines by impregnating the drippers with copper oxide particles

Schifris¹,

Schweitzer²,

Matan³

et al. 2015

Irrig Sci

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Neutralizing Viruses in Suspensions by Copper Oxide-Based Filters

Cited by 77 publications

References 7 publications

Deactivation of Human Immunodeficiency Virus Type 1 in Medium by Copper Oxide-Containing Filters

Deactivation of Human Immunodeficiency Virus Type 1 in Medium by Copper Oxide-Containing Filters

Incorporation of copper nanoparticles into paper for point-of-use water purification

Inhibition of root penetration in subsurface driplines by impregnating the drippers with copper oxide particles

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