Neutralizing Monoclonal Antibody to Periostin Inhibits Ovarian Tumor Growth and Metastasis

Zhu, Min; Saxton, Romaine E.; Ramos, Lillian; Chang, David D.; Karlan, Beth Y.; Gasson, Judith C.; Slamon, Dennis J.

doi:10.1158/1535-7163.mct-11-0046

Cited by 64 publications

(50 citation statements)

References 31 publications

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“…28,36 We used an alternative strategy of in vivo antisense administration after establishment of severe proteinuria and found that inhibition of periostin could remarkably diminish the inflammation and reverse the increase in proteinuria. The ability of periostin to play distinctive roles in crucial events during development of renal disease by promoting tissue inflammatory response, accumulation of extracellular matrix and podocyte damage underline periostin targeting as a potential efficient future treatment against CKD.…”

Section: Discussionmentioning

confidence: 99%

NFκB-Induced Periostin Activates Integrin-β3 Signaling to Promote Renal Injury in GN

Prakoura

Kavvadas

Kormann

et al. 2016

JASN

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De novo expression in the kidney of periostin, a protein involved in odontogenesis and osteogenesis, has been suggested as a biomarker of renal disease. In this study, we investigated the mechanism(s) of induction and the role of periostin in renal disease. Using a combination of bioinformatics, reporter assay, and chromatin immunoprecipitation analyses, we found that NFkB and other proinflammatory transcription factors induce periostin expression in vitro and that binding of these factors on the periostin promoter is enriched in glomeruli during experimental GN. Mice lacking expression of periostin displayed preserved renal function and structure during GN. Furthermore, delayed administration of periostin antisense oligonucleotides in wild-type animals with GN reversed already established proteinuria, diminished tissue inflammation, and improved renal structure. Lack of periostin expression also blunted the de novo renal expression of integrin-b3 and phosphorylation of focal adhesion kinase and AKT, known mediators of integrin-b3 signaling that affect cell motility and survival, observed during GN in wild-type animals. In vitro, recombinant periostin increased the expression of integrin-b3 and the concomitant phosphorylation of focal adhesion kinase and AKT in podocytes. Notably, periostin and integrin-b3 were highly colocalized in biopsy specimens from patients with inflammatory GN. These results demonstrate that interplay between periostin and renal inflammation orchestrates inflammatory and fibrotic responses, driving podocyte damage through downstream activation of integrin-b3 signaling. Targeting periostin may be a novel therapeutic strategy for treating CKD.

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Section: Discussionmentioning

confidence: 99%

NFκB-Induced Periostin Activates Integrin-β3 Signaling to Promote Renal Injury in GN

Prakoura

Kavvadas

Kormann

et al. 2016

JASN

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“…Increased expression of POSTN has been observed in various tumor types, including breast [44,48,[56][57][58], NSCLC [27,49,[59][60][61][62], colorectal [19,29,63], stomach cancers [64][65][66][67][68], pancreatic [32,69], prostate [70][71][72][73][74][75], ovarian cancer [76][77][78][79], and glioblastomas [80][81][82] (Table 1).…”

Section: Periostin Expression In Different Types Of Tumorsmentioning

confidence: 99%

“…In vivo Antibody directed against POSTN (MZ-1) inhibits the development of primary tumors derived from the periostin-expressing ovarian cancer cell line A2780 [77] Ovarian cancer IHC Expression of POSTN in cancer-associated stromal fibroblasts, but not in cancer cells. The 5-year survival rate was better in patients with negative POSTN expression than in those with positive POSTN expression.…”

Section: Ovarian Cancermentioning

confidence: 99%

The role of periostin in neoplastic processes

Ratajczak‐Wielgomas

Dzięgiel

2015

Folia Histochem Cytobiol.

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Periostin, also called osteoblast-specific factor 2 (OSF-2), is a multifunctional glycoprotein that belongs to the group of matricellular proteins. Due to its characteristic molecular structure containing integrin-binding domains, periostin is capable of binding to multiple integrin receptors (avb3, avb5, a6b4), thus affecting the regulation of the intracellular signaling pathways associated with protein kinases PI3K/AKT and focal adhesion kinase (FAK). This protein thus plays a role in the adhesion process, in the migration of many cells, and importantly, epithelial-mesenchymal transition of cancer cells. Periostin also participates in the processes of angiogenesis and lymphangiogenesis, metastases of cancer cells, and remodeling of the extracellular matrix. Increased expression of periostin has been observed in various tumor types, including breast, NSCLC, colorectal, pancreatic, prostate, and ovarian cancers, as well as tumors of the head and neck, and glioblastomas. Many groups have recently reported on periostin's key role in tumor progression, which suggests that periostin can be considered a potential therapeutic target.

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“…28 Zhu 2011: Neutralizing monoclonal antibody to periostin inhibited anchorage-independent growth of the periostin-expressing ovarian cancer cell line A2780. 38 Zhu 2011: Neutralizing monoclonal antibody to periostin inhibited periostin-induced cancer cell migration and invasion. 38 Jackson-Boeters 2009: Periostin expression coincides with 〈-SMA expression within the granulation tissue of excisional wounds of mice.…”

Section: /2mentioning

confidence: 99%

“…38 Zhu 2011: Neutralizing monoclonal antibody to periostin inhibited periostin-induced cancer cell migration and invasion. 38 Jackson-Boeters 2009: Periostin expression coincides with 〈-SMA expression within the granulation tissue of excisional wounds of mice. 10 Liu 2010: Inhibition of periostin expression via RNA interference suppressed proliferation of a human osteosarcoma cell line (U2OS).…”

Section: /2mentioning

confidence: 99%