Neutralizing antibody response to booster vaccination with the 17d yellow fever vaccine

Hepburn, Matthew J.; Kortepeter, Mark G.; Pittman, Phillip R.; Boudreau, Ellen F.; Mangiafico, Joseph A.; Buck, Peter; Norris, Sarah L.; Anderson, Edwin L.

doi:10.1016/j.vaccine.2005.12.055

Cited by 51 publications

(43 citation statements)

References 24 publications

(28 reference statements)

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“…They found an appropriate immune response to booster (defined as a 4-fold increase in serologic titers) in 78% (646 of 829) of persons with low titers ( 1:10) versus 10% (8 of 79) in persons who had prevaccination titers 1:40. 24 In the study conducted by BonnevieNielsen and others, only 1 of 10 persons who had received a dose of YF vaccine two years earlier had an antibody titer 1:10. Seven days after revaccination, this person had protective neutralizing antibodies.…”

Section: Resultsmentioning

confidence: 96%

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Efficacy and Duration of Immunity after Yellow Fever Vaccination: Systematic Review on the Need for a Booster Every 10 Years

Gotuzzo¹,

Yactayo²,

Córdova³

2013

The American Journal of Tropical Medicine and Hygiene

196

174

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Abstract. Current regulations stipulate a yellow fever (YF) booster every 10 years. We conducted a systematic review of the protective efficacy and duration of immunity of YF vaccine in residents of disease-endemic areas and in travelers to assess the need for a booster in these two settings and in selected populations (human immunodeficiency virus-infected persons, infants, children, pregnant women, and severely malnourished persons). Thirty-six studies and 22 reports were included. We identified 12 studies of immunogenicity, 8 of duration of immunity, 8 of vaccine response in infants and children, 7 of human-immunodeficiency virus-infected persons, 2 of pregnant women, and 1 of severely malnourished children. Based on currently available data, a single dose of YF vaccine is highly immunogenic and confers sustained life-long protective immunity against YF. Therefore, a booster dose of YF vaccine is not needed. Special considerations for selected populations are detailed.

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Section: Resultsmentioning

confidence: 96%

“…24,[37][38][39] This finding is true regardless of the reason for seronegativity: whether there was no seroconversion or the levels of neutralizing antibodies decreased below detectable levels over time. Hepburn and others conducted a retrospective study on YF vaccination among laboratory workers receiving annual serologic assessments.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and Duration of Immunity after Yellow Fever Vaccination: Systematic Review on the Need for a Booster Every 10 Years

Gotuzzo¹,

Yactayo²,

Córdova³

2013

The American Journal of Tropical Medicine and Hygiene

196

174

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“…3,4 Past studies have shown rapid seroconversion in adults from non-endemic regions, with antibodies appearing within 10 days and peaking 3-4 weeks after vaccination. 5,6 Our research goal was to assess seroconversion at 21 days and 8 months after YF vaccination in healthy adult travelers, and it was designed to be a potential comparator for a separate group of subjects receiving an investigational inactivated YF vaccine.…”

mentioning

confidence: 99%

Yellow Fever Vaccine Seroconversion in Travelers

Kay¹,

Chen²,

Sisti³

et al. 2011

The American Journal of Tropical Medicine and Hygiene

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“…Probably, this was due to multiple exposures and/or vaccinations. No indicative data were confirmed, because no consensus was found in the literature regarding the higher titers shown by Caucasians than by Blacks and Hispanics, as well as by men than by women 20,[22][23][24] . In a Brazilian study, a lower seroconversion rate was observed on antibody levels after vaccination against yellow fever in 12-month-old children who simultaneously received the triple viral vaccine than in those who received the 30-day interval vaccination.…”

Section: Discussionmentioning

confidence: 95%

Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil

Machado

Vasconcelos

Silva

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction:The yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present in the municipality of Luziânia, State of Goiás. Methods: Thirty-eight years later, a new seroepidemiological survey was conducted with the aim of assessing the degree of immune protection of the rural population of Luziânia, following the continuous attempts of public health services to obtain vaccination coverage in the region. A total of 383 volunteers, aged between 5 and 89 years and with predominant rural labor activities (75.5%), were interviewed. The presence of antibodies against the yellow fever was also investigated in these individuals, by using plaque reduction neutralization test, and correlated to information regarding residency, occupation, epidemiological data and immunity against the yellow fever virus. Results: We found a high (97.6%) frequency of protective titers (>1:10) of neutralizing antibodies against the yellow fever virus; the frequency of titers of 1:640 or higher was 23.2%, indicating wide immune protection against the disease in the study population. The presence of protective immunity was correlated to increasing age. Conclusions: This study reinforces the importance of surveys to address the immune state of a population at risk for yellow fever infection and to the surveillance of actions to control the disease in endemic areas.

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Neutralizing antibody response to booster vaccination with the 17d yellow fever vaccine

Cited by 51 publications

References 24 publications

Efficacy and Duration of Immunity after Yellow Fever Vaccination: Systematic Review on the Need for a Booster Every 10 Years

Efficacy and Duration of Immunity after Yellow Fever Vaccination: Systematic Review on the Need for a Booster Every 10 Years

Yellow Fever Vaccine Seroconversion in Travelers

Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil

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