Neutralizing antibodies against Coxsackie B viruses in patients with recent onset of type I diabetes

Mertens, Th.; Grüneklee, D.; Eggers, Hans J.

doi:10.1007/bf00442666

Cited by 24 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Epidemiological studies show a strong association between the development of T1D and enterovirus infection [25,[160][161][162], and antibodies against enterovirus [163][164][165][166][167][168][169] or T cell responses to enterovirus [170][171][172][173] have been detected in new-onset diabetic patients. In addition, enteroviral RNA was detected with high frequency in the serum or lymphocytes of T1D patients [174][175][176][177][178].…”

Section: Coxsackie Virusesmentioning

confidence: 99%

“…Several studies have reported that patients with recent-onset T1D had significantly higher titres of antibody to Coxsackie virus, especially the B4 serotype, than did non-diabetic controls [20][21][22]160,[163][164][165][166][167][168]. In addition, it was reported that T cell responses to Coxsackie B4 nonstructural protein of the virus increased in new-onset T1D patients [173].…”

Section: Coxsackie B Viruses and Human T1dmentioning

confidence: 99%

See 1 more Smart Citation

A New Look at Viruses in Type 1 Diabetes

Jun¹,

Yoon²

2004

ILAR Journal

View full text Add to dashboard Cite

Type 1 diabetes results from the destruction of pancreatic beta cells. Genetic factors are believed to be a major component for the development of type 1diabetes, but the concordance rate for the development of diabetes in identical twins is only about 40%, suggesting that non-genetic factors play an important role in the expression of the disease. Viruses are one environmental factor that is implicated in the pathogenesis of type 1 diabetes. To date, 14 different viruses have been reported to be associated with the development of type 1 diabetes in humans and animal models. Viruses may be involved in the pathogenesis of type 1 diabetes in at least two distinct ways: by inducing beta cellspecific autoimmunity, with or without infection of the beta cells, (e.g. Kilham rat virus) and by cytolytic infection and destruction of the beta cells (e.g. encephalomyocarditis virus in mice). With respect to virus-mediated autoimmunity, retrovirus, reovirus, Kilham rat virus, bovine viral diarrhoea-mucosal disease virus, mumps virus, rubella virus, cytomegalovirus and Epstein-Barr virus are discussed. With respect to the destruction of beta cells by cytolytic infection, encephalomyocarditis virus, mengovirus and Coxsackie B viruses are discussed. In addition, a review of transgenic animal models for virus-induced autoimmune diabetes is included, particularly with regard to lymphocytic choriomeningitis virus, influenza viral proteins and the EpsteinBarr viral receptor. Finally, the prevention of autoimmune diabetes by infection of viruses such as lymphocytic choriomeningitis virus is discussed.

show abstract

Section: Coxsackie Virusesmentioning

confidence: 99%

Section: Coxsackie B Viruses and Human T1dmentioning

confidence: 99%

A New Look at Viruses in Type 1 Diabetes

Jun¹,

Yoon²

2004

ILAR Journal

View full text Add to dashboard Cite

show abstract

“…Only a fraction of IDDM in man may be caused by coxsackie B viruses (Mertens et al, 1983). Our data from virus-induced diabetes in mice offer an explanation of why this disease rarely occurs, despite the occurrence of widespread virus infections.…”

Section: Discussionmentioning

confidence: 73%

Encephalomyocarditis Virus and Diabetes Mellitus: Studies on Virus Mutants in Susceptible and Non-susceptible Mice

Kruppenbacher¹,

Mertens²,

Müntefering³

et al. 1985

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

SUMMARYThe so-called M-variant (especially subtype D) of encephalomyocarditis virus (EMCV) induces a diabetes-like syndrome in certain mouse strains which may serve as a model of insulin-dependent diabetes mellitus (IDDM) in man. The development and course of diabetes was influenced by a number of virus and host factors, among these being virus strain, virus dose, mouse strain, age, sex, and the host's immunological status. In a D-variant stock of EMCV, we found a virus plaque variant (PV 2) diabetogenic for DBA/2 mice, and at least one variant (PV 7) that did not affect carbohydrate metabolism. Although the diabetogenicity of PV 2 proved to be a genetically stable characteristic after further passages in vivo and in vitro,

show abstract

“…coxsackie viruses and/or a greater frequency of positive serotests for several enteroviruses when comparing cases and control subjects [5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Several of the 'negative' studies deserve comment.…”

Section: For Debatementioning

confidence: 99%

“…Several of the 'negative' studies deserve comment. The Irish study [9] included non-insulin-dependent diabetic patients among its 'cases'.Two German studies [12,17] had no control subjects and concluded that coxsackie viruses could not be the aetiologic agent because they could not find evidence of infection in 100 % of cases. Another study tested for antibodies to only three coxsackie serotypes out of 67 known distinct serotypes of enteroviruses [13].…”

Section: For Debatementioning

confidence: 99%

Could the aetiology of IDDM be multifactorial?

Haverkos

1997

Diabetologia

View full text Add to dashboard Cite

Neutralizing antibodies against Coxsackie B viruses in patients with recent onset of type I diabetes

Cited by 24 publications

References 9 publications

A New Look at Viruses in Type 1 Diabetes

A New Look at Viruses in Type 1 Diabetes

Encephalomyocarditis Virus and Diabetes Mellitus: Studies on Virus Mutants in Susceptible and Non-susceptible Mice

Could the aetiology of IDDM be multifactorial?

Contact Info

Product

Resources

About