Neutralization of Infectious Bronchitis Virus Human Sera1

Miller, Louise T.; Yates, Vance J.

doi:10.1093/oxfordjournals.aje.a120901

Cited by 27 publications

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“…Previous studies of experimental and natural infections with human and animal coronaviruses have revealed heterologous antibody responses (13)(14)(15)(16)(17)(18). In our earlier study (7) of antibodies to 229E and OC 43 in human sera, simultaneous seroresponses were not found among 103 of 104 paired sera with a diagnostic antibody rise to either virus, despite the fact that over 30 per cent of these pairs had preexisting antibody to the other virus.…”

Section: Resultsmentioning

confidence: 57%

Seroepidemiologic Survey of Coronavirus (Strain 229e) Infections in a Population of Children

Kaye¹,

Dowdle²

1975

American Journal of Epidemiology

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The indirect hemagglutination (IHA) test for coronavirus 229E antibodies was used for serodiagnostic and seroepidemiologic studies in a population of children. Subjects ranged in age from 5 to 19 years and lived in a home which participated in a longitudinal surveilance of respiratory illness (1960-1968). During this period 1477 respiratory illnesses were observed; 63 (4%) were associated with sero-response (fourfold or greater antibody rises) to 229E. An additional 105 sero-responses were associated with unreported or subclinical illness. The frequency of these infections was cyclical, and 229E and coronavirus OC 43 infections peaked in different years among the same population. Sero-responses occurred mainly in the fall, winter and spring quarters. Preexisting antibody was demonstrated in one-third of the children with 229E sero-responses. Clinical studies indicated that the most frequent complaints with 229E infections were sore throat, coryza and cough, and the most frequent findings were pharyngeal injection, coryza and fever.

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Section: Resultsmentioning

confidence: 57%

Seroepidemiologic Survey of Coronavirus (Strain 229e) Infections in a Population of Children

Kaye¹,

Dowdle²

1975

American Journal of Epidemiology

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“…Previous reports have shown the presence in humans of antibody to animal coronaviruses (Hartley et at., 1964;Miller & Yates, 1968) and the existence of serological cross-reactions among and between human and animal coronavirus strains (Mclntosh et aL, 1967a, b;Kaye & Dowdle, 1969;Bradburne, 1970;Pedersen et al, 1978). The detection in human sera of antibody to NCDCV suggested the existence of an enteric coronavirus in man (Sharpee & Mebus, 1975).…”

Section: Discussionmentioning

confidence: 99%

Antigenic and Biological Relationships between Human Coronavirus OC43 and Neonatal Calf Diarrhoea Coronavirus

Gerna¹,

Cereda²,

Revello³

et al. 1981

Journal of General Virology

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SUMMARYMonospecific antisera were prepared in mice to human coronavirus OC43 and neonatal calf diarrhoea coronavirus (NCDC V) which had been previously adapted to growth in suckling mouse brain. Brain suspension from infected suckling mice was used as immunogen. The antigenic relationship between OC43 and NCDCV was studied by the indirect immunoperoxidase antibody technique, by the haemagglutination-inhibition (HI) test and a new infectious centre-reduction neutralization test. In mouse immune sera, a two-way cross-reaction between OC43 and NCDCV was detected. However, the antigenic relationship appeared to be closer for internal (as shown by immunoperoxidase staining) as compared to surface antigens (as shown by HI and neutralization). In primary infections of natural hosts there was a high degree of cross-reactivity between the two coronavirus strains for both surface and internal antigens, and homologous and heterologous titres were consistently within an eightfold dilution difference by all tests. Most human adults and calves had antibody to both OC43 and NCDCV and geometric mean titres of homologous antibody were higher than titres of heterologous antibody. Although OC43 and NCDCV share antigenic determinants, they possessed several different biological properties, including plaque morphology by the infectious centre assay, agglutination of 1-day-old chick erythrocytes and resistance of haemagglutinin to physical and chemical treatments.

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“…Heterogeneous antibody to human coronavirus could, however, give some low level of cross-reactivity with A-IBV (8). NDV also has a low level of antigenic cross-reactivity with human mumps virus, a fact that may have contributed to the positive reactions found in some of the serological tests used including the ELISA (10).…”

Section: Resultsmentioning

confidence: 99%

“…Clinical infection of humans with A-IBV has not been reported although subelinical infection with the virus has been suggested when two populations differing in exposure to poultry were studied for the presence of antibody to A-IBV. Antibodies were found only among individuals who had worked closely with poultry (8).…”

Section: Avian Infectious Bronchitis Virusmentioning

confidence: 99%

Detection of antibody to avian viruses in human populations

1990

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SUMMARYThe ability of three avian viruses to elicit antibody response in humans was surveyed for the purpose of identifying zoonotic diseases. Antibody levels in people associated with poultry were compared to those in people having limited poultry association. Antibody levels to three avian viruses: infectious bursal disease virus, a birnavirus; Newcastle disease virus, a paramyxovirus; and avian infectious bronchitis virus, a coronavirus were determined by enzyme–linked immunosorbent assays (ELISA). Differences between the two study groups were evident: people having a known association with poultry showed significantly higher levels of antibodies to Newcastle disease and avian infectious bronchitis virus. Antibodies detected may be due to virus exposure rather than zoonoses.

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Neutralization of Infectious Bronchitis Virus Human Sera1

Cited by 27 publications

References 0 publications

Seroepidemiologic Survey of Coronavirus (Strain 229e) Infections in a Population of Children

Seroepidemiologic Survey of Coronavirus (Strain 229e) Infections in a Population of Children

Antigenic and Biological Relationships between Human Coronavirus OC43 and Neonatal Calf Diarrhoea Coronavirus

Detection of antibody to avian viruses in human populations

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